A Series of COVID-19 Cases With Findings in the Gastrointestinal and Hepatobiliary System.
atypical covid-19 symptoms
case report series
case series
covid-19
gastrointestinal infection
microthrombi
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
accepted:
23
02
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide. Most of the infected patients present with respiratory symptoms and acute lung damage. Here, we present three cases of patients with COVID-19 disease whose main clinical manifestations are gastrointestinal symptoms. In our first case, we present a COVID-19 patient with histologic findings associated with ischemic necrosis of the small bowel. In the second and third cases, we demonstrate acute cholecystitis and histology showing microvascular thrombosis. These three cases highlight the ischemic and thrombotic changes seen in the setting of COVID-19 infection without classic respiratory symptoms, with resulting severe gastrointestinal and hepatobiliary disease requiring surgical management. Although the bile or stool viral load was not tested in these patients, the small intestine and gallbladder were infected with SARS-CoV-2, most likely via the epithelial angiotensin-converting enzyme 2 (ACE2) receptor.
Identifiants
pubmed: 35355548
doi: 10.7759/cureus.22602
pmc: PMC8957856
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e22602Informations de copyright
Copyright © 2022, Wu et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Gastrointest Endosc. 2021 Jan;93(1):263-264
pubmed: 32682813
Ann Transl Med. 2021 Nov;9(21):1631
pubmed: 34926675
JAMA Netw Open. 2020 Jun 1;3(6):e2011335
pubmed: 32525549
Cureus. 2021 Jun 3;13(6):e15431
pubmed: 34258107
BMC Infect Dis. 2020 Jun 22;20(1):437
pubmed: 32571224
J Hepatol. 2020 Dec;73(6):1566-1568
pubmed: 32890595
JAMA Oncol. 2020 Jul 1;6(7):1108-1110
pubmed: 32211820
Int J Infect Dis. 2020 Jul;96:19-24
pubmed: 32311451
Biomolecules. 2021 Oct 20;11(11):
pubmed: 34827548
Transl Res. 2020 Jun;220:1-13
pubmed: 32299776
J Infect Dis. 2020 Nov 9;222(11):1807-1815
pubmed: 32914853
Lancet Respir Med. 2020 Apr;8(4):420-422
pubmed: 32085846
Thromb Res. 2021 Apr;200:1-8
pubmed: 33493983
World J Clin Cases. 2021 Jun 6;9(16):3796-3813
pubmed: 34141737
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Ann Med Surg (Lond). 2020 Dec;60:434-437
pubmed: 33224493
World J Emerg Surg. 2020 Jun 8;15(1):38
pubmed: 32513287
Therap Adv Gastroenterol. 2020 Jun 18;13:1756284820934626
pubmed: 32595762
Int J Mol Sci. 2021 Nov 08;22(21):
pubmed: 34769508
Int J Surg Case Rep. 2022 Jan;90:106731
pubmed: 34976597
Tumour Biol. 2015 Jul;36(7):5171-7
pubmed: 25663464
Crit Rev Oncol Hematol. 2020 Jun;150:102972
pubmed: 32344317
Lancet Oncol. 2020 Mar;21(3):335-337
pubmed: 32066541
Crit Care. 2020 Jul 13;24(1):422
pubmed: 32660650
Cureus. 2020 Sep 29;12(9):e10722
pubmed: 33145128
Am J Surg Pathol. 2022 Jan 1;46(1):89-96
pubmed: 34081038
World J Emerg Surg. 2020 Jul 2;15(1):43
pubmed: 32615987