Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.
brain imaging
circadian rhythm
emotional faces task
emotional processing
headache onset
pain
Journal
Frontiers in human neuroscience
ISSN: 1662-5161
Titre abrégé: Front Hum Neurosci
Pays: Switzerland
ID NLM: 101477954
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
12
2021
accepted:
10
02
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Previous studies suggested a circadian variation of migraine attack onset, although, with contradictory results - possibly because of the existence of migraine subgroups with different circadian attack onset peaks. Migraine is primarily a brain disorder, and if the diversity in daily distribution of migraine attack onset reflects an important aspect of migraine, it may also associate with interictal brain activity. Our goal was to assess brain activity differences in episodic migraine subgroups who were classified according to their typical circadian peak of attack onset. Two fMRI studies were conducted with migraine without aura patients ( In both studies, significantly increased neural activation was detected to fearful (but not sad or happy) faces. In Study 1, the Evening start group showed increased activation compared to the Morning start group in regions involved in emotional, self-referential (left posterior cingulate gyrus, right precuneus), pain (including left middle cingulate, left postcentral, left supramarginal gyri, right Rolandic operculum) and sensory (including bilateral superior temporal gyrus, right Heschl's gyrus) processing. While in Study 2, the Morning start group showed increased activation compared to the Varying start group at a nominally significant level in regions with pain (right precentral gyrus, right supplementary motor area) and sensory processing (bilateral paracentral lobule) functions. Our fMRI studies suggest that different circadian attack onset peaks are associated with interictal brain activity differences indicating heterogeneity within migraine patients and alterations in sensitivity to threatening fearful stimuli. Circadian variation of migraine attack onset may be an important characteristic to address in future studies and migraine prophylaxis.
Sections du résumé
Background
UNASSIGNED
Previous studies suggested a circadian variation of migraine attack onset, although, with contradictory results - possibly because of the existence of migraine subgroups with different circadian attack onset peaks. Migraine is primarily a brain disorder, and if the diversity in daily distribution of migraine attack onset reflects an important aspect of migraine, it may also associate with interictal brain activity. Our goal was to assess brain activity differences in episodic migraine subgroups who were classified according to their typical circadian peak of attack onset.
Methods
UNASSIGNED
Two fMRI studies were conducted with migraine without aura patients (
Results
UNASSIGNED
In both studies, significantly increased neural activation was detected to fearful (but not sad or happy) faces. In Study 1, the Evening start group showed increased activation compared to the Morning start group in regions involved in emotional, self-referential (left posterior cingulate gyrus, right precuneus), pain (including left middle cingulate, left postcentral, left supramarginal gyri, right Rolandic operculum) and sensory (including bilateral superior temporal gyrus, right Heschl's gyrus) processing. While in Study 2, the Morning start group showed increased activation compared to the Varying start group at a nominally significant level in regions with pain (right precentral gyrus, right supplementary motor area) and sensory processing (bilateral paracentral lobule) functions.
Conclusion
UNASSIGNED
Our fMRI studies suggest that different circadian attack onset peaks are associated with interictal brain activity differences indicating heterogeneity within migraine patients and alterations in sensitivity to threatening fearful stimuli. Circadian variation of migraine attack onset may be an important characteristic to address in future studies and migraine prophylaxis.
Identifiants
pubmed: 35355585
doi: 10.3389/fnhum.2022.842426
pmc: PMC8959375
doi:
Types de publication
Journal Article
Langues
eng
Pagination
842426Informations de copyright
Copyright © 2022 Baksa, Szabo, Kocsel, Galambos, Edes, Pap, Zsombok, Magyar, Gecse, Dobos, Kozak, Bagdy, Kokonyei and Juhasz.
Déclaration de conflit d'intérêts
Preliminary data from this study were presented at the 5th Conference of the European Society for Cognitive and Affective Neuroscience, 23–26 June 2021, Online (poster presentation); and at the 33rd ECNP Congress, 12–15 September 2020, Virtual (poster presentation) and the related abstract was published in European Neuropsychopharmacology Volume 40, Supplement 1, November 2020, Pages S241–S242. GB is a member of the Board of Directors at Gedeon Richter and AE is an employee of Gedeon Richter Plc. Medical Division, but the company did not provide any funding or had any further role in the preparation of the article. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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