Uncoupling the Vicious Cycle of Mechanical Stress and Inflammation in Calcific Aortic Valve Disease.
aortic stenosis (AS)
calcific aortic valve disease (CAVD)
inflammation
mechanotransduction
monocytes
platelets
shear stress
valvular interstitial cells (VIC)
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
09
2021
accepted:
15
02
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Calcific aortic valve disease (CAVD) is a common acquired valvulopathy, which carries a high burden of mortality. Chronic inflammation has been postulated as the predominant pathophysiological process underlying CAVD. So far, no effective medical therapies exist to halt the progression of CAVD. This review aims to outline the known pathways of inflammation and calcification in CAVD, focussing on the critical roles of mechanical stress and mechanosensing in the perpetuation of valvular inflammation. Following initiation of valvular inflammation, dysregulation of proinflammatory and osteoregulatory signalling pathways stimulates endothelial-mesenchymal transition of valvular endothelial cells (VECs) and differentiation of valvular interstitial cells (VICs) into active myofibroblastic and osteoblastic phenotypes, which in turn mediate valvular extracellular matrix remodelling and calcification. Mechanosensitive signalling pathways convert mechanical forces experienced by valve leaflets and circulating cells into biochemical signals and may provide the positive feedback loop that promotes acceleration of disease progression in the advanced stages of CAVD. Mechanosensing is implicated in multiple aspects of CAVD pathophysiology. The mechanosensitive RhoA/ROCK and YAP/TAZ systems are implicated in aortic valve leaflet mineralisation in response to increased substrate stiffness. Exposure of aortic valve leaflets, endothelial cells and platelets to high shear stress results in increased expression of mediators of VIC differentiation. Upregulation of the Piezo1 mechanoreceptor has been demonstrated to promote inflammation in CAVD, which normalises following transcatheter valve replacement. Genetic variants and inhibition of Notch signalling accentuate VIC responses to altered mechanical stresses. The study of mechanosensing pathways has revealed promising insights into the mechanisms that perpetuate inflammation and calcification in CAVD. Mechanotransduction of altered mechanical stresses may provide the sought-after coupling link that drives a vicious cycle of chronic inflammation in CAVD. Mechanosensing pathways may yield promising targets for therapeutic interventions and prognostic biomarkers with the potential to improve the management of CAVD.
Identifiants
pubmed: 35355968
doi: 10.3389/fcvm.2022.783543
pmc: PMC8959593
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
783543Informations de copyright
Copyright © 2022 Dayawansa, Baratchi and Peter.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Mol Cell Cardiol. 2016 May;94:13-20
pubmed: 26996755
Cardiovasc Pathol. 2007 Sep-Oct;16(5):268-76
pubmed: 17868877
Int J Inflam. 2011;2011:364310
pubmed: 21826258
Catheter Cardiovasc Interv. 2006 Aug;68(2):183-92
pubmed: 16810699
Genome Biol. 2017 May 5;18(1):83
pubmed: 28476144
Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1369-91
pubmed: 17588873
J Res Med Sci. 2020 Jun 30;25:65
pubmed: 33088302
J Heart Valve Dis. 2014 Jul;23(4):484-91
pubmed: 25803975
Am J Transl Res. 2016 Dec 15;8(12):5773-5783
pubmed: 28078049
N Engl J Med. 2005 Jun 9;352(23):2389-97
pubmed: 15944423
J Am Coll Cardiol. 2019 Oct 15;74(15):1851-1863
pubmed: 31491546
Front Cardiovasc Med. 2017 Nov 21;4:74
pubmed: 29209618
Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):936-42
pubmed: 19304575
J Am Coll Cardiol. 2014 Feb 11;63(5):470-7
pubmed: 24161338
Am Heart J. 2014 Feb;167(2):235-40
pubmed: 24439985
Circ Res. 2005 Apr 15;96(7):792-9
pubmed: 15761200
Genes Dev. 1998 May 1;12(9):1260-8
pubmed: 9573043
Am J Cardiol. 2009 Jul 1;104(1):122-4
pubmed: 19576331
Circ Res. 2004 Oct 15;95(8):773-9
pubmed: 15388638
Tissue Eng. 2006 Apr;12(4):905-15
pubmed: 16674302
Circ Res. 2021 Apr 30;128(9):1398-1417
pubmed: 33914604
Circ Res. 2011 Jun 10;108(12):1510-24
pubmed: 21659654
PLoS One. 2013 Jun 06;8(6):e65201
pubmed: 23762316
Biomech Model Mechanobiol. 2014 Aug;13(4):813-26
pubmed: 24292631
Am J Med. 1981 Mar;70(3):519-30
pubmed: 6782873
J Am Coll Cardiol. 2019 May 7;73(17):2150-2162
pubmed: 31047003
Sci Rep. 2019 Sep 10;9(1):12934
pubmed: 31506459
Circulation. 2012 Sep 11;126(11 Suppl 1):S222-30
pubmed: 22965987
Eur Heart J. 2005 Jul;26(13):1333-41
pubmed: 15827062
N Engl J Med. 2013 Feb 7;368(6):503-12
pubmed: 23388002
Scand Cardiovasc J. 2016 Jun;50(3):138-45
pubmed: 26911132
Am J Pathol. 2001 Oct;159(4):1335-43
pubmed: 11583961
J Mol Cell Cardiol. 2014 Feb;67:49-59
pubmed: 24368096
J Thorac Cardiovasc Surg. 2017 Jun;153(6):1318-1327.e1
pubmed: 28283241
Trends Mol Med. 2017 Sep;23(9):850-868
pubmed: 28811171
Am J Physiol Cell Physiol. 2000 Dec;279(6):C1880-8
pubmed: 11078703
Circulation. 2000 Mar 14;101(10):1130-7
pubmed: 10715259
Biotechnol Bioeng. 2014 Nov;111(11):2326-37
pubmed: 24898772
J Am Coll Cardiol. 2001 Oct;38(4):1078-82
pubmed: 11583885
Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1429-34
pubmed: 15117733
Am J Cardiovasc Dis. 2011;1(2):185-99
pubmed: 22254198
Nat Rev Cardiol. 2018 Nov;15(11):685-704
pubmed: 30287945
J Interv Cardiol. 2009 Jun;22(3):291-8
pubmed: 19490359
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1580-90
pubmed: 23640488
Thromb Haemost. 2008 Apr;99(4):711-9
pubmed: 18392329
J Am Coll Cardiol. 2019 Jan 22;73(2):190-209
pubmed: 30654892
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
Biomaterials. 2018 Oct;181:268-279
pubmed: 30096561
ASAIO J. 2007 Jan-Feb;53(1):17-22
pubmed: 17237644
Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H756-64
pubmed: 19151254
Atherosclerosis. 2015 Sep;242(1):251-260
pubmed: 26232165
J Thorac Cardiovasc Surg. 2012 Dec;144(6):1466-70
pubmed: 23026565
Scand J Infect Dis. 1997;29(4):361-5
pubmed: 9360250
J Thorac Cardiovasc Surg. 2009 Oct;138(4):1008-15
pubmed: 19664780
Circulation. 2006 Jun 13;113(23):2744-53
pubmed: 16754802
Int J Inflam. 2011;2011:263870
pubmed: 21760982
Metabolites. 2021 Jul 16;11(7):
pubmed: 34357353
Eur Heart J. 2017 Sep 21;38(36):2739-2791
pubmed: 28886619
Cardiovasc Res. 2020 Apr 1;116(5):983-994
pubmed: 31393559
Blood Rev. 2007 May;21(3):157-71
pubmed: 17118501
Arterioscler Thromb Vasc Biol. 1997 Apr;17(4):646-53
pubmed: 9108776
Ann Biomed Eng. 2010 Mar;38(3):788-800
pubmed: 19953319
PLoS One. 2015 Apr 13;10(4):e0123257
pubmed: 25874717
J Am Coll Cardiol. 2012 Sep 11;60(11):1027; author reply 1027
pubmed: 22954244
Am J Cardiol. 2002 Sep 1;90(5):551-4
pubmed: 12208424
Ann Biomed Eng. 2005 Jun;33(6):772-9
pubmed: 16078617
Cardiovasc Res. 2008 Jan;77(1):221-30
pubmed: 18006450
Nature. 2005 Sep 8;437(7056):270-4
pubmed: 16025100
Cardiovasc Pathol. 2013 Jan-Feb;22(1):1-8
pubmed: 22795219
Cardiovasc Res. 1986 Oct;20(10):760-7
pubmed: 3791342
Nat Rev Mol Cell Biol. 2017 Dec;18(12):758-770
pubmed: 28951564
J Am Coll Cardiol. 1997 Mar 1;29(3):630-4
pubmed: 9060903
Br Heart J. 1992 Jun;67(6):445-9
pubmed: 1622692
Int Heart J. 2019 Mar 20;60(2):345-351
pubmed: 30745535
Biomaterials. 2017 Jul;131:131-144
pubmed: 28390245
Nature. 1968 Sep 7;219(5158):1059-61
pubmed: 5673366
Circulation. 1968 Jul;38(1 Suppl):61-7
pubmed: 4894151
Endocrinology. 2001 Dec;142(12):5050-5
pubmed: 11713196
J Mol Cell Cardiol. 2004 Jan;36(1):57-66
pubmed: 14734048
Circ Res. 1990 Aug;67(2):448-60
pubmed: 2376081
Immunity. 2005 Oct;23(4):344-6
pubmed: 16226499
J Am Heart Assoc. 2017 Sep 14;6(9):
pubmed: 28912209
J Am Coll Cardiol. 2012 Apr 17;59(16):1452-9
pubmed: 22497825
J Am Coll Cardiol. 2008 Sep 2;52(10):843-50
pubmed: 18755348
Arterioscler Thromb Vasc Biol. 2015 Jul;35(7):1597-605
pubmed: 26023079
Circulation. 2000 Oct 24;102(17):2045-50
pubmed: 11044418
Circulation. 2002 Oct 22;106(17):2224-30
pubmed: 12390952
Thromb Haemost. 2010 Feb;103(2):408-14
pubmed: 20024494
Am J Hematol. 2015 Jan;90(1):15-9
pubmed: 25242620
Elife. 2020 Jun 02;9:
pubmed: 32484440
Vasc Med. 2011 Oct;16(5):365-77
pubmed: 22003002
J Clin Med. 2020 Jun 25;9(6):
pubmed: 32630544
Blood Adv. 2019 Mar 12;3(5):777-788
pubmed: 30846427
Circulation. 2001 Mar 20;103(11):1522-8
pubmed: 11257079
Circ Cardiovasc Imaging. 2016 Oct;9(10):
pubmed: 27733431
N Engl J Med. 1992 Nov 5;327(19):1329-35
pubmed: 1406834
Biomech Model Mechanobiol. 2014 Nov;13(6):1209-25
pubmed: 24599392
Am J Cardiol. 2010 Sep 1;106(5):713-9
pubmed: 20723651
Atherosclerosis. 2020 Aug;306:59-67
pubmed: 32222287
Biomech Model Mechanobiol. 2012 Sep;11(7):1085-96
pubmed: 22294208
Cardiovasc Res. 2006 Aug 1;71(3):548-56
pubmed: 16740254
Atherosclerosis. 2001 Oct;158(2):385-90
pubmed: 11583717
J Pathol. 2000 May;191(1):54-60
pubmed: 10767719
Nanomaterials (Basel). 2018 May 03;8(5):
pubmed: 29751516
Int J Cardiovasc Res. 2016 Jan 3;5(1):
pubmed: 27468412
Circulation. 2016 Nov 29;134(22):1766-1784
pubmed: 27895025
Nutr Metab Cardiovasc Dis. 2015 Jun;25(6):519-25
pubmed: 25816732
J Mol Cell Cardiol. 2009 Dec;47(6):828-34
pubmed: 19695258
Scand Cardiovasc J. 2019 Apr;53(2):91-97
pubmed: 31109205
J Am Coll Cardiol. 2014 Jun 10;63(22):e57-185
pubmed: 24603191
Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1421-36
pubmed: 17581807
Circ J. 2011;75(6):1305-13
pubmed: 21566338
Eur Heart J Cardiovasc Imaging. 2015 Aug;16(8):834-41
pubmed: 25796267
Cell Rep. 2016 Nov 8;17(7):1739-1746
pubmed: 27829145
Eur Heart J. 2003 Jan;24(2):198-208
pubmed: 12573277
Cardiovasc Eng. 2010 Mar;10(1):5-11
pubmed: 20107896
Circulation. 2001 Nov 20;104(21):2525-32
pubmed: 11714645
N Engl J Med. 2020 Nov 5;383(19):1838-1847
pubmed: 32865380
N Engl J Med. 2020 Feb 27;382(9):799-809
pubmed: 31995682
N Engl J Med. 2017 Apr 6;376(14):1321-1331
pubmed: 28304219
Sci Adv. 2021 Feb 5;7(6):
pubmed: 33547080
Cardiology. 2010;117(3):184-9
pubmed: 21079402
Cathet Cardiovasc Diagn. 1993 May;29(1):1-7
pubmed: 8495464
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1767-78
pubmed: 18263709
Circ Res. 2010 Oct 29;107(9):1047-57
pubmed: 21030722
Am J Pathol. 2007 Nov;171(5):1407-18
pubmed: 17823281
Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):254-60
pubmed: 19023092
Acta Biomater. 2016 May;36:42-54
pubmed: 26947381
Circulation. 1994 Aug;90(2):844-53
pubmed: 7519131
J Mol Cell Cardiol. 2015 Mar;80:175-85
pubmed: 25633835
Pathol Res Pract. 2012 Apr 15;208(4):231-4
pubmed: 22436689
Circulation. 1995 Nov 1;92(9):2690-6
pubmed: 7586374
PLoS One. 2012;7(10):e48154
pubmed: 23110195
Arterioscler Thromb Vasc Biol. 2020 Apr;40(4):885-900
pubmed: 32160774
Circulation. 2016 Dec 6;134(23):1848-1862
pubmed: 27789555
Elife. 2019 Sep 16;8:
pubmed: 31524599
J Pathol Clin Res. 2015 Jun 24;1(4):195-206
pubmed: 27499904
Circulation. 2016 Aug 9;134(6):455-68
pubmed: 27486164
J Biomed Mater Res A. 2012 Sep;100(9):2474-82
pubmed: 22581728
N Engl J Med. 2017 Sep 21;377(12):1119-1131
pubmed: 28845751
J Mol Cell Cardiol. 2013 Jul;60:27-35
pubmed: 23583836
Sci Transl Med. 2019 Sep 11;11(509):
pubmed: 31511425
Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1398-405
pubmed: 27199449
Circ Res. 2018 Mar 2;122(5):774-789
pubmed: 29496799
Echocardiography. 2011 Jan;28(1):1-7
pubmed: 20678125
Immune Netw. 2016 Feb;16(1):26-32
pubmed: 26937229
Ann Thorac Surg. 1980 Sep;30(3):230-9
pubmed: 7425702
Biol Rev Camb Philos Soc. 2022 Apr;97(2):604-614
pubmed: 34781417
N Engl J Med. 2012 Nov 15;367(20):1954-6
pubmed: 23150964
Circ Res. 2021 Apr 30;128(9):1317-1319
pubmed: 33914606
Can J Cardiol. 1996 Mar;12(3):231-6
pubmed: 8624972
JACC Basic Transl Sci. 2020 Jul 01;5(7):649-661
pubmed: 32760854
Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):69-77
pubmed: 16293796
Cardiovasc Pathol. 1997 May-Jun;6(3):167-74
pubmed: 25850328
FASEB J. 2008 Jun;22(6):1769-77
pubmed: 18218921
J Am Coll Cardiol. 2009 Feb 10;53(6):491-500
pubmed: 19195606
Circulation. 2011 Oct 18;124(16):1783-91
pubmed: 22007101
Circ Res. 2021 Apr 30;128(9):1371-1397
pubmed: 33914608
Thromb Haemost. 2017 Dec;117(12):2346-2355
pubmed: 29212122
Circulation. 2010 Jan 19;121(2):306-14
pubmed: 20048204
Heart. 2015 Jun;101(12):943-7
pubmed: 25655063
Arterioscler Thromb Vasc Biol. 2006 Sep;26(9):2117-24
pubmed: 16840715
J Clin Med. 2019 Feb 25;8(2):
pubmed: 30823621
Eur J Pharmacol. 2009 Jan 5;602(1):28-35
pubmed: 19056377
Blood. 2008 Nov 1;112(9):3650-60
pubmed: 18544680
Circ Res. 2004 Nov 26;95(11):1046-57
pubmed: 15564564
Arterioscler Thromb Vasc Biol. 2020 Nov;40(11):e296-e308
pubmed: 32938214
Circ Res. 2004 Aug 6;95(3):253-60
pubmed: 15217906
J Mol Cell Cardiol. 1998 Aug;30(8):1559-69
pubmed: 9737942
Biochem Biophys Res Commun. 2007 Oct 26;362(3):550-3
pubmed: 17719560
J Biomech. 2016 Sep 6;49(13):2635-2643
pubmed: 27282961
Stem Cell Res Ther. 2013;4(5):107
pubmed: 24004875
J Biomech Eng. 2010 Jan;132(1):014505
pubmed: 20524753
Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):636-644
pubmed: 29348122
J Clin Invest. 1995 Mar;95(3):1363-9
pubmed: 7883983
Clin Chim Acta. 2011 May 12;412(11-12):925-9
pubmed: 21266168
Arterioscler Thromb Vasc Biol. 1996 Apr;16(4):523-32
pubmed: 8624774
Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):121-30
pubmed: 23104848
Eur Heart J. 2021 Aug 7;42(30):2935-2951
pubmed: 34179958
Artif Organs. 2018 Feb;42(2):E1-E12
pubmed: 29226341
Acta Cardiol. 2003 Aug;58(4):321-6
pubmed: 12948037
J Am Coll Cardiol. 2013 Sep 10;62(11):1002-12
pubmed: 23727214
Am J Cardiol. 2015 Jan 1;115(1):86-92
pubmed: 25456876
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1924-32
pubmed: 24903096
PLoS One. 2012;7(10):e48843
pubmed: 23119099
J Am Coll Cardiol. 2007 Nov 13;50(20):1992-8
pubmed: 17996566
PLoS One. 2011;6(11):e27743
pubmed: 22110751
Int J Cardiol. 2019 Jul 1;286:121-126
pubmed: 30952530
J Cardiovasc Transl Res. 2017 Feb;10(1):27-34
pubmed: 28097522
Acta Biomater. 2011 May;7(5):2101-8
pubmed: 21255691
N Engl J Med. 2008 Sep 25;359(13):1343-56
pubmed: 18765433
Circulation. 2021 Jun 22;143(25):2418-2427
pubmed: 33913339
FASEB J. 2003 Sep;17(12):1648-57
pubmed: 12958171
PLoS One. 2013 Dec 23;8(12):e84433
pubmed: 24376809
J Cell Sci. 2020 Dec 21;133(24):
pubmed: 33443070
Int J Cardiol. 2009 Jun 12;135(1):4-13
pubmed: 19386374
J Cardiovasc Dev Dis. 2014 Dec;1(3):237-256
pubmed: 29552567
J Cell Physiol. 2021 Apr;236(4):2976-2987
pubmed: 32959903
J Clin Invest. 1996 Jun 15;97(12):2692-6
pubmed: 8675678
Heart. 2002 Oct;88(4):348-51
pubmed: 12231589
Sci Rep. 2017 Jun 13;7(1):3375
pubmed: 28611395
J Am Coll Cardiol. 2000 Dec;36(7):2257-62
pubmed: 11127470
Circulation. 2020 Sep 15;142(11):1092-1105
pubmed: 32697107
J Am Coll Cardiol. 1993 Apr;21(5):1220-5
pubmed: 8459080
EMBO Rep. 2010 Dec;11(12):902-3
pubmed: 21052093
Ann Thorac Surg. 2003 Feb;75(2):457-65; discussion 465-6
pubmed: 12607654
Front Cardiovasc Med. 2019 Jan 10;5:197
pubmed: 30687719
Ann Biomed Eng. 2011 Aug;39(8):2174-85
pubmed: 21455792
Am J Cardiol. 1986 Aug 1;58(3):304-8
pubmed: 3739919