Regional Differences in Mucociliary Clearance in the Upper and Lower Airways.
mucociliary clearance
mucus blanket
posterior nasopharynx
tracheal posterior membrane
tracheal walls
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
12
2021
accepted:
24
01
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must be removed to keep the lower airways sterile. Thus, one might expect vigorous removal of these substances via mucociliary clearance (MCC) in this region. We have investigated the rate of MCC in the murine nasal cavity compared to the more distal airways (trachea). The rate of MCC in the nasal cavity (posterior nasopharynx, PNP) was ∼3-4× greater than on the tracheal wall. This appeared to be due to a more abundant population of ciliated cells in the nasal cavity (∼80%) compared to the more sparsely ciliated trachea (∼40%). Interestingly, the tracheal ventral wall exhibited a significantly lower rate of MCC than the tracheal posterior membrane. The trachealis muscle underlying the ciliated epithelium on the posterior membrane appeared to control the surface architecture and likely in part the rate of MCC in this tracheal region. In one of our mouse models (
Identifiants
pubmed: 35356083
doi: 10.3389/fphys.2022.842592
pmc: PMC8959816
doi:
Types de publication
Journal Article
Langues
eng
Pagination
842592Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL125280
Pays : United States
Informations de copyright
Copyright © 2022 Rogers, Button, Kelada, Ostrowski, Livraghi-Butrico, Gutay, Esther and Grubb.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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