Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going?
calcium induced calcium release
excitation contraction coupling (ECC)
mathematical modeling
ryanodine receptor (RyR)
super resolution microscopy
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
12
2021
accepted:
31
01
2022
entrez:
31
3
2022
pubmed:
1
4
2022
medline:
1
4
2022
Statut:
epublish
Résumé
Complementary developments in microscopy and mathematical modeling have been critical to our understanding of cardiac excitation-contraction coupling. Historically, limitations imposed by the spatial or temporal resolution of imaging methods have been addressed through careful mathematical interrogation. Similarly, limitations imposed by computational power have been addressed by imaging macroscopic function in large subcellular domains or in whole myocytes. As both imaging resolution and computational tractability have improved, the two approaches have nearly merged in terms of the scales that they can each be used to interrogate. With this review we will provide an overview of these advances and their contribution to understanding ventricular myocyte function, including exciting developments over the last decade. We specifically focus on experimental methods that have pushed back limits of either spatial or temporal resolution of nanoscale imaging (e.g., DNA-PAINT), or have permitted high resolution imaging on large cellular volumes (e.g., serial scanning electron microscopy). We also review the progression of computational approaches used to integrate and interrogate these new experimental data sources, and comment on near-term advances that may unify understanding of the underlying biology. Finally, we comment on several outstanding questions in cardiac physiology that stand to benefit from a concerted and complementary application of these new experimental and computational methods.
Identifiants
pubmed: 35356084
doi: 10.3389/fphys.2022.834211
pmc: PMC8959215
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
834211Informations de copyright
Copyright © 2022 Louch, Perdreau-Dahl and Edwards.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Science. 1965 Jan 8;147(3654):158-60
pubmed: 14220445
PLoS Comput Biol. 2019 Aug 8;15(8):e1007260
pubmed: 31393876
Circ Res. 2014 Jul 7;115(2):252-62
pubmed: 24786399
Crit Rev Biomed Eng. 1993;21(1):1-77
pubmed: 8365198
J Physiol. 1952 Apr;116(4):449-72
pubmed: 14946713
Biochemistry. 2008 Dec 30;47(52):13985-90
pubmed: 19053230
Elife. 2017 Nov 14;6:
pubmed: 29135437
J Theor Biol. 2010 Oct 7;266(3):408-18
pubmed: 20620154
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):14958-63
pubmed: 17848521
J Struct Biol. 2006 Jul;155(1):63-73
pubmed: 16713294
J Physiol. 1975 Aug;249(3):497-517
pubmed: 1177102
Cardiovasc Res. 2013 May 1;98(2):307-14
pubmed: 23524301
Science. 1995 May 19;268(5213):1045-9
pubmed: 7754384
Nature. 1964 Apr 25;202:355-7
pubmed: 14152819
J Gen Physiol. 1981 Nov;78(5):457-97
pubmed: 6796647
J Gen Physiol. 2010 Aug;136(2):129-33
pubmed: 20660655
Biophys J. 2011 Sep 21;101(6):1287-96
pubmed: 21943409
J Mol Cell Cardiol. 2016 Mar;92:82-92
pubmed: 26827896
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4305-10
pubmed: 16537526
ACS Nano. 2019 Feb 26;13(2):2143-2157
pubmed: 30715853
Front Physiol. 2012 May 31;3:157
pubmed: 22783195
J Cell Biol. 1964 Sep;22:675-96
pubmed: 14208357
Circ Res. 2011 Apr 1;108(7):847-56
pubmed: 21311044
Biophys J. 2008 Oct;95(8):3724-37
pubmed: 18641070
J Bioenerg Biomembr. 1989 Apr;21(2):227-46
pubmed: 2546931
Cardiovasc Res. 2015 Dec 1;108(3):387-98
pubmed: 26490742
Physiol Rev. 1977 Jan;57(1):71-108
pubmed: 13441
Sci Rep. 2020 May 15;10(1):8076
pubmed: 32415205
Biophys J. 2002 Dec;83(6):2918-45
pubmed: 12496068
Biophys J. 1997 Jul;73(1):97-111
pubmed: 9199775
Physiol Rev. 1997 Jul;77(3):699-729
pubmed: 9234963
Biophys J. 2020 Jan 7;118(1):232-242
pubmed: 31839264
Circ Res. 2011 Jan 21;108(2):210-8
pubmed: 21148431
Genes (Basel). 2018 Dec 11;9(12):
pubmed: 30544986
Elife. 2020 Jan 09;9:
pubmed: 31916935
Biophys J. 2009 Nov 18;97(10):2664-73
pubmed: 19917219
J Mol Cell Cardiol. 2013 Jan;54:98-100
pubmed: 23123322
Proc R Soc Lond B Biol Sci. 1987 Mar 23;230(1259):163-205
pubmed: 2884668
Circ Res. 2005 Nov 25;97(11):1173-81
pubmed: 16239587
Nat Med. 2014 Jun;20(6):624-32
pubmed: 24836577
Methods. 2021 Sep;193:27-37
pubmed: 33059034
Am J Physiol. 1996 Jan;270(1 Pt 1):C148-59
pubmed: 8772440
Biophys J. 2006 Aug 1;91(3):779-92
pubmed: 16679359
Circ Res. 2005 Mar 18;96(5):543-50
pubmed: 15705962
J Physiol. 2010 Jan 1;588(Pt 1):225-42
pubmed: 19900959
J Physiol. 1962 Feb;160:317-52
pubmed: 14480151
Circ Res. 2008 Dec 5;103(12):1466-72
pubmed: 19008475
Biophys J. 1992 Aug;63(2):497-517
pubmed: 1330031
Science. 2011 Sep 9;333(6048):1440-5
pubmed: 21903813
Circ Res. 2012 Mar 30;110(7):968-77
pubmed: 22374134
Circ Res. 2006 Feb 3;98(2):235-44
pubmed: 16373600
Circ Res. 1997 Dec;81(6):1034-44
pubmed: 9400385
J Clin Invest. 2008 Jun;118(6):2230-45
pubmed: 18483626
Nature. 1975 Feb 13;253(5492):556-8
pubmed: 163977
J Struct Biol. 2005 Feb;149(2):219-24
pubmed: 15681238
Basic Res Cardiol. 2008 Jul;103(4):328-44
pubmed: 18347833
Nature. 1970 Oct 3;228(5266):34-6
pubmed: 5456208
Science. 1993 Oct 29;262(5134):740-4
pubmed: 8235594
Front Physiol. 2018 Dec 11;9:1773
pubmed: 30618792
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22275-80
pubmed: 20018773
J Gen Physiol. 2017 Sep 4;149(9):847-855
pubmed: 28798276
Biol Bull. 1949 Apr;96(2):140-61
pubmed: 18120626
J Physiol. 2006 Jul 15;574(Pt 2):519-33
pubmed: 16709642
Biophys J. 2008 Oct;95(8):3767-89
pubmed: 18676655
Biophys J. 2004 Mar;86(3):1293-307
pubmed: 14990462
Nat Med. 2009 Mar;15(3):325-30
pubmed: 19198614
Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3456-61
pubmed: 16481613
J Biol Chem. 2001 May 18;276(20):16931-5
pubmed: 11279144
Circ Res. 2011 Apr 1;108(7):871-83
pubmed: 21454795
Cell. 2016 Mar 24;165(1):192-206
pubmed: 27015312
Science. 1998 Jan 9;279(5348):234-7
pubmed: 9422697
J Physiol. 2019 Jan;597(2):399-418
pubmed: 30412283
Circ Res. 2009 Aug 14;105(4):335-42
pubmed: 19628792
J Mol Cell Cardiol. 2013 May;58:172-81
pubmed: 23220288
Biophys J. 2014 May 20;106(10):2222-32
pubmed: 24853751
J Theor Biol. 1985 Mar 21;113(2):379-94
pubmed: 3999782
Fed Proc. 1985 Dec;44(15):2964-9
pubmed: 2998887
Science. 1990 Apr 20;248(4953):372-6
pubmed: 2158146
J Clin Invest. 2010 Dec;120(12):4197-203
pubmed: 21099119
Biophys J. 2004 Dec;87(6):3723-36
pubmed: 15465866
J Physiol. 1958 Dec 30;144(3):426-41
pubmed: 13621406
J Physiol. 1952 Apr;116(4):424-48
pubmed: 14946712
Elife. 2018 Oct 30;7:
pubmed: 30375974
Science. 2016 Oct 21;354(6310):
pubmed: 27708056
J Physiol. 2010 Dec 1;588(Pt 23):4743-57
pubmed: 20962003
Annu Rev Physiol. 1999;61:311-35
pubmed: 10099691
Circ Res. 2013 Nov 8;113(11):1219-30
pubmed: 24044951
Circulation. 2010 Dec 21;122(25):2669-79
pubmed: 21098440
J Mol Cell Cardiol. 2010 Oct;49(4):617-24
pubmed: 20655925
Nat Methods. 2018 Sep;15(9):685-688
pubmed: 30127504
J Physiol. 2007 Sep 1;583(Pt 2):685-94
pubmed: 17599964
Biophys J. 2006 Mar 15;90(6):1999-2014
pubmed: 16387773
J Electrocardiol. 1987 Jul;20(3):219-26
pubmed: 3309111
Circ Res. 1972 Sep;31(3):293-307
pubmed: 4341466
J Gen Physiol. 1965 Jul;48(6):997-1002
pubmed: 5855513
Circ Res. 2008 Oct 10;103(8):e105-15
pubmed: 18787194
J Cell Biol. 1995 May;129(3):659-71
pubmed: 7730402
Physiol Rev. 2002 Oct;82(4):893-922
pubmed: 12270947
Circulation. 2016 Jan 26;133(4):388-97
pubmed: 26733606
J Physiol. 1952 Apr;116(4):497-506
pubmed: 14946715
J Mol Cell Cardiol. 2013 May;58:53-8
pubmed: 23369697
Eur J Transl Myol. 2014 Dec 24;25(1):4747
pubmed: 26913143
J Cell Sci. 2009 Apr 1;122(Pt 7):1005-13
pubmed: 19295127
J Gen Physiol. 1965 Jan;48:455-79
pubmed: 14284779
Science. 1989 May 19;244(4906):800-3
pubmed: 2543067
Nat Med. 2014 Feb;20(2):184-92
pubmed: 24441828
PLoS Biol. 2004 Dec;2(12):e439
pubmed: 15597117
J Physiol. 2012 Sep 15;590(18):4403-22
pubmed: 22495592
Circulation. 2013 Feb 26;127(8):913-22
pubmed: 23363625
Biophys J. 2002 Jul;83(1):59-78
pubmed: 12080100
Circ Arrhythm Electrophysiol. 2011 Dec;4(6):947-57
pubmed: 22009705
Proc Natl Acad Sci U S A. 2004 Aug 31;101(35):13062-7
pubmed: 15322274
J Mol Cell Cardiol. 2021 Apr;153:86-92
pubmed: 33359037
J Am Coll Cardiol. 2021 Feb 2;77(4):405-419
pubmed: 33509397
Prog Biophys Mol Biol. 2011 May;105(3):129-33
pubmed: 21163291
J Mol Cell Cardiol. 2014 Nov;76:1-11
pubmed: 25149127
J Biophys Biochem Cytol. 1957 Mar 25;3(2):269-300
pubmed: 13438910
Circ Res. 2012 Jun 22;111(1):28-36
pubmed: 22628577
Nature. 1984 Nov 29-Dec 5;312(5993):444-6
pubmed: 6504155
J Physiol. 2019 Apr;597(8):2139-2162
pubmed: 30714156
Cardiovasc Res. 2017 Jul 01;113(8):879-891
pubmed: 28444133
Biophys Chem. 1998 May 5;72(1-2):87-100
pubmed: 9652087
IEEE Trans Biomed Eng. 2014 May;61(5):1457-65
pubmed: 24759278
Biophys J. 2015 Nov 17;109(10):2037-50
pubmed: 26588563
Ann N Y Acad Sci. 1998 Sep 16;853:20-30
pubmed: 10603933
Front Physiol. 2021 Sep 09;12:718404
pubmed: 34566684
Biophys J. 1997 Jul;73(1):112-22
pubmed: 9199776
Biophys J. 1999 Sep;77(3):1528-39
pubmed: 10465763
Cell Rep. 2018 Jan 9;22(2):557-567
pubmed: 29320748
J Physiol. 1996 Apr 1;492 ( Pt 1):31-8
pubmed: 8730580
PLoS Biol. 2004 Nov;2(11):e329
pubmed: 15514700
PLoS Comput Biol. 2017 Aug 31;13(8):e1005714
pubmed: 28859079
Circ Res. 1977 Feb;40(2):119-29
pubmed: 403028
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):18911-6
pubmed: 17142314
Circ Res. 2012 Aug 3;111(4):402-14
pubmed: 22723297
Biophys J. 2013 May 21;104(10):2149-59
pubmed: 23708355
Biophys J. 2018 Oct 2;115(7):1160-1165
pubmed: 30220413
J Mol Cell Cardiol. 2013 May;58:41-52
pubmed: 23376034
Science. 2006 Sep 15;313(5793):1642-5
pubmed: 16902090
J Mol Cell Cardiol. 2015 Mar;80:45-55
pubmed: 25536181
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4036-40
pubmed: 3858861
Biophys J. 2014 Dec 16;107(12):3018-3029
pubmed: 25517166
Am J Physiol Heart Circ Physiol. 2004 Apr;286(4):H1471-9
pubmed: 14670817
Biophys J. 2008 Aug;95(3):1412-27
pubmed: 18390622
Front Physiol. 2021 Oct 27;12:763584
pubmed: 34777021
Proc Natl Acad Sci U S A. 1988 Jan;85(2):441-5
pubmed: 2448775
Nano Lett. 2010 Nov 10;10(11):4756-61
pubmed: 20957983
Nat Biotechnol. 2021 May;39(5):551-554
pubmed: 33398151
J Mol Cell Cardiol. 1974 Dec;6(6):543-59
pubmed: 4140916
J Physiol. 1975 Aug;249(3):469-95
pubmed: 809571
J Physiol. 1952 Apr;116(4):473-96
pubmed: 14946714
Circ Res. 2006 Aug 18;99(4):398-406
pubmed: 16840718
Cell. 2000 May 12;101(4):365-76
pubmed: 10830164
Biophys J. 2012 Jun 6;102(11):2433-42
pubmed: 22713558
Circulation. 2004 Nov 16;110(20):3168-74
pubmed: 15505083
J Physiol. 1952 Aug;117(4):500-44
pubmed: 12991237
Cardiovasc Res. 2009 Dec 1;84(3):387-95
pubmed: 19617226
Proc Natl Acad Sci U S A. 1985 Nov;82(21):7256-9
pubmed: 2414773
Ann N Y Acad Sci. 2005 Jun;1047:76-85
pubmed: 16093486
J Physiol. 1994 Feb 1;474(3):463-71
pubmed: 8014907
J Mol Cell Cardiol. 2010 Jul;49(1):25-32
pubmed: 20353795
J Gen Physiol. 1978 Nov;72(5):667-99
pubmed: 739258
J Physiol. 1998 Nov 1;512 ( Pt 3):677-91
pubmed: 9769413
Fed Proc. 1985 Dec;44(15):2970-6
pubmed: 2415405
Circ Res. 2012 Mar 16;110(6):796-9
pubmed: 22427320
J Biol Chem. 1987 Feb 5;262(4):1740-7
pubmed: 3805051