AAA+ proteins: one motor, multiple ways to work.
AAA+
ClpA
ClpB
Hsp104
clpx
Journal
Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897
Informations de publication
Date de publication:
29 04 2022
29 04 2022
Historique:
received:
02
11
2021
revised:
14
03
2022
accepted:
15
03
2022
pubmed:
1
4
2022
medline:
3
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Numerous ATPases associated with diverse cellular activities (AAA+) proteins form hexameric, ring-shaped complexes that function via ATPase-coupled translocation of substrates across the central channel. Cryo-electron microscopy of AAA+ proteins processing substrate has revealed non-symmetric, staircase-like hexameric structures that indicate a sequential clockwise/2-residue step translocation model for these motors. However, for many of the AAA+ proteins that share similar structural features, their translocation properties have not yet been experimentally determined. In the cases where translocation mechanisms have been determined, a two-residue translocation step-size has not been resolved. In this review, we explore Hsp104, ClpB, ClpA and ClpX as examples to review the experimental methods that have been used to examine, in solution, the translocation mechanisms employed by AAA+ motor proteins. We then ask whether AAA+ motors sharing similar structural features can have different translocation mechanisms. Finally, we discuss whether a single AAA+ motor can adopt multiple translocation mechanisms that are responsive to different challenges imposed by the substrate or the environment. We suggest that AAA+ motors adopt more than one translocation mechanism and are tuned to switch to the most energetically efficient mechanism when constraints are applied.
Identifiants
pubmed: 35356966
pii: 231102
doi: 10.1042/BST20200350
pmc: PMC9115847
mid: NIHMS1798684
doi:
Substances chimiques
Escherichia coli Proteins
0
Adenosine Triphosphate
8L70Q75FXE
Adenosine Triphosphatases
EC 3.6.1.-
AAA Proteins
EC 3.6.4.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-906Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM099836
Pays : United States
Informations de copyright
© 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
Références
J Mol Biol. 2016 May 8;428(9 Pt B):1870-85
pubmed: 26608812
Nat Struct Mol Biol. 2020 May;27(5):406-416
pubmed: 32313240
Crit Rev Biochem Mol Biol. 2022 Apr;57(2):188-204
pubmed: 34923891
Biophys J. 2019 May 21;116(10):1856-1872
pubmed: 31027887
Nat Struct Mol Biol. 2008 Jun;15(6):641-50
pubmed: 18488042
Proteins. 2015 Nov;83(11):2008-24
pubmed: 26313457
Biochemistry. 2009 Oct 6;48(39):9221-33
pubmed: 19650643
Cell. 2018 Apr 19;173(3):677-692.e20
pubmed: 29677512
J Biol Chem. 2021 Sep;297(3):101066
pubmed: 34384781
Elife. 2019 Jun 11;8:
pubmed: 31184588
Proteins. 2015 Jan;83(1):117-34
pubmed: 25363713
Elife. 2020 Feb 28;9:
pubmed: 32108573
Nat Struct Mol Biol. 2005 Jan;12(1):4-6
pubmed: 15689967
Mol Cell Biol. 2006 Nov;26(22):8488-97
pubmed: 16966379
Biochemistry. 1994 Nov 29;33(47):14306-16
pubmed: 7947840
Biophys J. 2019 Apr 23;116(8):1380-1385
pubmed: 30952364
Nature. 2005 Oct 20;437(7062):1115-20
pubmed: 16237435
Chem Biol. 2012 Nov 21;19(11):1400-10
pubmed: 23177195
Blood. 2022 Feb 3;139(5):779-791
pubmed: 34115842
Mol Cell. 2011 May 6;42(3):367-77
pubmed: 21549313
Cell. 2011 Apr 15;145(2):257-67
pubmed: 21496645
EMBO J. 1982;1(8):945-51
pubmed: 6329717
Nat Struct Mol Biol. 2014 Oct;21(10):871-5
pubmed: 25195048
Nat Commun. 2016 Oct 27;7:13301
pubmed: 27786171
Elife. 2020 Jun 23;9:
pubmed: 32573439
PLoS Biol. 2012;10(6):e1001346
pubmed: 22723742
Nat Struct Mol Biol. 2012 Dec;19(12):1338-46
pubmed: 23160353
Cold Spring Harb Perspect Biol. 2019 Aug 1;11(8):
pubmed: 30745294
J Mol Biol. 2013 Aug 9;425(15):2795-812
pubmed: 23639359
Structure. 2019 Mar 5;27(3):449-463.e7
pubmed: 30595457
Nat Struct Mol Biol. 2016 Sep;23(9):830-7
pubmed: 27478928
Nat Struct Mol Biol. 2021 Dec;28(12):964-971
pubmed: 34824462
Nature. 1999 Mar 25;398(6725):348-51
pubmed: 10192337
Nat Struct Mol Biol. 2015 Jun;22(6):492-8
pubmed: 25938660
Trends Biochem Sci. 1996 Aug;21(8):289-96
pubmed: 8772382
Biochemistry. 2016 Mar 29;55(12):1758-71
pubmed: 26891079
EMBO J. 2019 May 2;38(9):
pubmed: 30877095
Nat Struct Mol Biol. 2020 Jun;27(6):540-549
pubmed: 32367069
Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9560-E9569
pubmed: 30257943
Biophys J. 2003 Oct;85(4):2224-39
pubmed: 14507688
Curr Biol. 2020 Mar 23;30(6):R251-R257
pubmed: 32208144
J Biol Chem. 2014 Jan 10;289(2):848-67
pubmed: 24280225
J Biol Chem. 1969 Jun 25;244(12):3290-302
pubmed: 4307313
Annu Rev Biochem. 1996;65:169-214
pubmed: 8811178
Cell Rep. 2020 Dec 1;33(9):108418
pubmed: 33264628
Science. 2016 Feb 19;351(6275):871-5
pubmed: 26822609
Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7333-7342
pubmed: 30918129
Cell. 2012 Nov 9;151(4):778-793
pubmed: 23141537
Biophys J. 2020 Oct 6;119(7):1335-1350
pubmed: 32997959
Science. 2019 Aug 2;365(6452):
pubmed: 31249135
Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11037-42
pubmed: 12177439
Mol Cell. 2015 Mar 5;57(5):836-849
pubmed: 25620563
Nature. 2021 Sep;597(7874):132-137
pubmed: 34408321
Nat Commun. 2015 Oct 14;6:8520
pubmed: 26465836
Cell. 2012 Nov 9;151(4):695-697
pubmed: 23141530
Genome Biol. 2008 Apr 30;9(4):216
pubmed: 18466635
Cell. 2004 Nov 24;119(5):653-65
pubmed: 15550247
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9864-9869
pubmed: 28847957
Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3768-72
pubmed: 11259663
Eukaryot Cell. 2014 May;13(5):635-47
pubmed: 24632242
Crit Rev Biochem Mol Biol. 2022 Apr;57(2):156-187
pubmed: 34632886
Nat Struct Mol Biol. 2004 Jul;11(7):607-15
pubmed: 15208691
Nat Struct Mol Biol. 2020 Feb;27(2):202-209
pubmed: 32042153
PLoS One. 2011;6(10):e26319
pubmed: 22022600
Genes Cells. 2001 Jul;6(7):575-97
pubmed: 11473577
Mol Cell. 2022 Feb 17;82(4):741-755.e11
pubmed: 35148816
PLoS Genet. 2017 Oct 30;13(10):e1007085
pubmed: 29084237
Sci Adv. 2021 Sep 03;7(36):eabg4674
pubmed: 34516899
EMBO J. 2008 Oct 22;27(20):2712-24
pubmed: 18833196
Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9384-9392
pubmed: 32277033
Science. 2004 Jun 18;304(5678):1793-7
pubmed: 15155912
Elife. 2020 Jan 09;9:
pubmed: 31916936
Nature. 1976 Oct 14;263(5578):615-8
pubmed: 980111
Mol Cell. 2006 Aug 4;23(3):425-38
pubmed: 16885031
J Mol Biol. 2010 Jun 25;399(5):665-79
pubmed: 20380838
Science. 2017 Jul 21;357(6348):273-279
pubmed: 28619716
Science. 2017 Nov 3;358(6363):
pubmed: 29097521
J Clin Invest. 2008 Sep;118(9):3087-97
pubmed: 18704197
PLoS Genet. 2013;9(9):e1003781
pubmed: 24039611
Nature. 2020 Feb;578(7794):317-320
pubmed: 31996849
Annu Rev Biophys Biomol Struct. 2006;35:93-114
pubmed: 16689629
Protein Sci. 2020 Feb;29(2):407-419
pubmed: 31599052
Nat Struct Mol Biol. 2010 Apr;17(4):485-91
pubmed: 20364131
Sci Rep. 2019 Feb 20;9(1):2421
pubmed: 30787316
Cell Rep. 2021 May 25;35(8):109166
pubmed: 34038719
Front Mol Biosci. 2018 Oct 02;5:85
pubmed: 30333982
Biochem J. 2015 Aug 15;470(1):39-52
pubmed: 26251445
Cell. 2011 Apr 29;145(3):459-69
pubmed: 21529717
Chem Biol. 2015 Aug 20;22(8):1074-86
pubmed: 26256479
Cell Rep. 2020 Feb 25;30(8):2644-2654.e3
pubmed: 32101742
J Biol Chem. 2013 Aug 9;288(32):23436-45
pubmed: 23775070
Elife. 2014 Dec 09;3:
pubmed: 25490068
Elife. 2020 Oct 22;9:
pubmed: 33089779
Nat Commun. 2019 Jun 3;10(1):2393
pubmed: 31160557