Clinicopathologic characteristics of pancreatic islet amyloidosis in the rhesus macaque (Macaca mulatta) and sooty mangabey (Cercocebus atys).
diabetes mellitus
fructosamine
glucagon
glucosuria
human islet amyloid polypeptide
hyperglycemia
immunohistochemistry
insulin
pancreatic islet amyloid
serum amyloid P
Journal
Journal of medical primatology
ISSN: 1600-0684
Titre abrégé: J Med Primatol
Pays: Denmark
ID NLM: 0320626
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
11
02
2022
received:
21
12
2021
accepted:
26
02
2022
pubmed:
1
4
2022
medline:
28
4
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Diabetes mellitus type 2 has been linked to pancreatic islet amyloid deposition in humans and nonhuman primates. The authors hypothesized that diabetic primates would have significant differences in pathology than non-diabetic groups. This retrospective study used histopathology and immunohistochemistry to characterize and compare pancreatic islet amyloidosis in 58 diabetic and non-diabetic rhesus macaque (RM) and sooty mangabeys (SM). The pancreatic tissues from diabetic RM and SM showed higher histopathology scores for islet amyloid deposit distribution, severity, and calcification deposits compared to their respective non-diabetic cohorts. Further, these tissues from RM and SM with amyloid deposits showed immunoreactivity to insulin, glucagon, islet amyloid polypeptide, serum amyloid P, and glucagon-like peptide 1. Histopathology results showed that the defined amyloid characteristics are associated with clinical diabetes in both species. The immunohistochemistry results collectively suggest differences in pancreatic hormones and islet amyloid components among both species and diabetic status.
Sections du résumé
BACKGROUND
Diabetes mellitus type 2 has been linked to pancreatic islet amyloid deposition in humans and nonhuman primates. The authors hypothesized that diabetic primates would have significant differences in pathology than non-diabetic groups.
METHODS
This retrospective study used histopathology and immunohistochemistry to characterize and compare pancreatic islet amyloidosis in 58 diabetic and non-diabetic rhesus macaque (RM) and sooty mangabeys (SM).
RESULTS
The pancreatic tissues from diabetic RM and SM showed higher histopathology scores for islet amyloid deposit distribution, severity, and calcification deposits compared to their respective non-diabetic cohorts. Further, these tissues from RM and SM with amyloid deposits showed immunoreactivity to insulin, glucagon, islet amyloid polypeptide, serum amyloid P, and glucagon-like peptide 1.
CONCLUSIONS
Histopathology results showed that the defined amyloid characteristics are associated with clinical diabetes in both species. The immunohistochemistry results collectively suggest differences in pancreatic hormones and islet amyloid components among both species and diabetic status.
Substances chimiques
Amyloid
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-164Subventions
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
American Diabetes Association. Classification and diagnosis of diabetes: standards of medical care in diabetes-2021. Diabetes Care. 2020;43(Suppl 1):S15-S33. doi:10.2337/dc21-S002
Simmons HA. Age-associated pathology in rhesus macaques (Macaca mulatta). Vet Pathol. 2016;53(2):399-416. doi:10.1177/0300985815620628
de Koning EJ, Bodkin NL, Hansen BC, Clark A. Diabetes mellitus in Macaca mulatta monkeys is characterised by islet amyloidosis and reduction in beta-cell population. Diabetologia. 1993;36(5):378-384. doi:10.1007/bf00402271
Wagner JD, Cann JA, Zhang L, Harwood JJ. Diabetes and Obesity Research Using Non-Human Primates. Nonhuman Primates in Biomedical Research. 2nd ed. Elsevier; 2012:699-732: chap 14. American College of Laboratory Animal Medicine.
Jones AC, Herndon JG, Courtney CL, Collura L, Cohen JK. Clinicopathologic characteristics, prevalence, and risk factors of spontaneous diabetes in sooty Mangabeys (Cercocebus atys). Comp Med. 2014;3:200-210.
Howard CF. Diabetes in Macaca nigra: metabolic and histologic changes. Diabetologia. 1974;10:671-677. doi:10.1007/BF01222003
Hubbard GB, Steele KE, Davis KJ, Leland MM. Spontaneous pancreatic islet amyloidosis in 40 baboons. J Med Primatol. 2002;31(2):84-90. doi:10.1034/j.1600-0684.2002.01020.x
Guardado-Mendoza R, Davalli AM, Chavez AO, et al. Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons. Biol Sci. 2009;106:13992-13997. doi:10.1073/pnas.0906471106
Cann JA, Kavanagh K, Jorgensen ML, et al. Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys. Vet Pathol. 2010;47(4):713-718. doi:10.1177/0300985810370011
Ohagi S, Nishi M, Bell GI, Ensinck JW, Steiner DF. Sequences of islet amyloid polypeptide precursors of an Old World monkey, the pig-tailed macaque (Macaca nemestrina), and the dog (Canis familiaris). Diabetologia. 1991;34(8):555-558. doi:10.1007/BF00400272
Howard C. Nonhuman primates as models for the study of human diabetes mellitus. Diabetes. 1982;31(Suppl 1 Pt 2):37-42. doi:10.2337/diab.31.1.s37
McTighe MS, Hansen BC, Ely JJ, Lee DR. Determination of hemoglobin A1c and fasting blood glucose reference intervals in captive chimpanzees (pan troglodytes). J Am Assoc Lab Anim Sci. 2011;50(2):165-170.
Hayden MR, Tyagi SC. "a" is for amylin and amyloid in type 2 diabetes mellitus. JOP. 2001;2(4):124-139.
Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals. 8th ed. National Academic Press; 2010.
Bauer SA, Leslie KE, Pearl DL, Fournier J, Turner PV. Retrospective case-control study of hyperglycemia in group-housed, mature female cynomolgus macaques (Macaca fascicularis). J Med Primatol. 2010;39(6):408-416. doi:10.1111/j.1600-0684.2010.00417.x
Wagner JD, Kavanagh K, Ward GM, Auerbach BJ, Harwood HJ, Kaplan JR. Old World nonhuman primate models of type 2 diabetes mellitus. ILAR J. 2006;47(3):259-271. doi:10.1093/ilar.47.3.259
Williams-Fritze MJ, Smith PC, Zelterman D, Scholz JAC. Fructosamine reference ranges in rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci. 2011;4:462-465.
Sharma P, Chennareddi L, Greene-Hartsfield EZ, Villinger F, Cohen JK, Herndon JG. Hematology and serum chemistry values of sooty mangabeys (Cercocebus atys): comparison with rhesus monkeys. J Med Primatol 2014 Apr 2014;43(2)10.1111/jmp.12091, 43, 78, 88.
Magden ER, Mansfield KG, Simmons JH, Abee CR. Nonhuman PRIMATES. In: Fox JG, Anderson LC, Otto GM, Pritchett-Corning KR, Whary MT, eds. Laboratory Animal Medicine. 3rd ed. Academic Press; 2015:771-930: chap 17.
Brady AG, Carville AAL. Digestive system diseases of Nonhuman Primates. Nonhuman Primates in Biological Research. 2nd ed. Elsevier; 2012:589-627: chap 12. American College of Laboratory Animal Medicine.
Silvestri G, Sodora D, Koup R, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003;18:441-452. doi:10.1016/s1074-7613(03)00060-8
Davis KJ, Bell RC, Wilhelmsen CL, Langford MJ, Montali RJ. Immunohistochemical analysis of spontaneous pancreatic islet amyloid deposits in nonhuman primates: case-report. Vet Pathol. 2016;31(4):479-480. doi:10.1177/030098589403100414
O'Brien T, Wagner J, Litwak K, et al. Islet amyloid and islet amyloid polypeptide in cynomolgus macaques (Macaca fascicularis): an animal model of human non-insulin-dependent diabetes mellitus. Vet Pathol. 1996;33(5):479-485. doi:10.1177/030098589603300501
Asthana S, Mallick B, Alexandrescu AT, Jha S. IAPP in type II diabetes: Basic research on structure, molecular interactions, and disease mechanisms suggests potential intervention strategies. Biochim Biophys Acta Biomembranes. 2018;1860(9):1765-1782. doi:10.1016/j.bbamem.2018.02.020
Iki K, Pour PM. Distribution of pancreatic endocrine cells including IAPP-expressing cells in non-diabetic and type 2 diabetic cases. J Histochem Cytochem. 2007;55(2):111-118. doi:10.1369/jhc.6A7024.2006
Kiernan UA, Nedelkov D, Tubbs K, Niederkofler E, Nelson R. Proteomic characterization of novel serum amyloid P component variants from human plasma and urine. Proteomics. 2004;4(6):1825-1829. doi:10.1002/pmic.200300690
Hazenberg BP, van Rijswijk MH, Lub-de Hooge MN, et al. Diagnostic performance and prognostic value of extravascular retention of 123I-labeled serum amyloid P component in systemic amyloidosis. J Nucl Med. 2007;48(6):865-872. doi:10.2967/jnumed.106.039313