Patient-reported outcome during radiotherapy for head and neck cancer: the use of different PRO questionnaires.
Head and neck cancer
Patient-reported outcomes
Quality of life
Radiotherapy
Side effects
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
20
01
2022
accepted:
16
03
2022
pubmed:
1
4
2022
medline:
7
7
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Head and neck cancer (HNC) patients are typically treated with radiotherapy (RT), which might lead to side effects and deterioration of quality of life (QoL). Studies in other cancers indicate that systematic use of patient-reported outcome (PRO) can be a tool to increase awareness of patients' symptoms and improve QoL. Multiple PRO questionnaires have been developed and validated for HNC, complicating the interpretation of results from scientific studies. In this exploratory study, symptom scores from four essential symptoms present in four different HNC-specific PRO questionnaires were evaluated. Four HNC-specific PRO questionnaires (EORTC QLQ-H&N35, FACT-H&N, MDASI-HN, and PRO-CTCAE) for patients undergoing radiotherapy were completed by eligible HNC patients up to ten times during and after RT. Four essential symptoms (pain, dysphagia, hoarseness, and dry mouth) were present in all questionnaires. The symptom scores for these symptoms were aligned and evaluated. Twelve patients were included and completed a total of 328 PRO questionnaires out of 420. Similarity between symptom score for the four symptoms was found, when the symptom scores were aligned. The symptom scores increased during RT and decreased afterwards for all four symptoms and in all four questionnaires. Four HNC-specific PRO questionnaires are found similar in reflecting symptom scores over time concerning four important HNC symptoms (pain, dysphagia, hoarseness, and dry mouth). PRO can contribute with targetable information about symptoms, and PRO questionnaires might be a valuable add on to clinical practice enabling a varied picture of patients' symptoms during radiotherapy.
Identifiants
pubmed: 35357578
doi: 10.1007/s00405-022-07364-0
pii: 10.1007/s00405-022-07364-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4199-4206Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Lo Nigro C, Denaro N, Merlotti A, Merlano M (2017) Head and neck cancer: improving outcomes with a multidisciplinary approach. Cancer Manage Res. https://doi.org/10.2147/CMAR.S115761
doi: 10.2147/CMAR.S115761
Dirix P, Nuyts S, van den Bogaert W (2006) Radiation-induced xerostomia in patients with head and neck cancer: a literature review. Cancer. https://doi.org/10.1002/cncr.22302
doi: 10.1002/cncr.22302
pubmed: 17078052
Marta GN, Silva V, de Andrade CH, de Arruda FF, Hanna SA, Gadia R et al (2014) Intensity-modulated radiation therapy for head and neck cancer: Systematic review and meta-analysis. Radiother Oncol. https://doi.org/10.1016/j.radonc.2013.11.010
doi: 10.1016/j.radonc.2013.11.010
pubmed: 25480094
Hamilton SN, Tran E, Ho C, Berthelet E, Wu J, DeVries K et al (2020) Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer. Support Care Cancer. https://doi.org/10.1007/s00520-020-05778-2
doi: 10.1007/s00520-020-05778-2
pubmed: 33180201
pmcid: 8113356
Rosenthal DI, Mendoza TR, Fuller CD, Hutcheson KA, Wang XS, Hanna EY et al (2014) Patterns of symptom burden during radiotherapy or concurrent chemoradiotherapy for head and neck cancer: a prospective analysis using the University of Texas MD Anderson Cancer Center Symptom Inventory-Head and Neck Module. Cancer. https://doi.org/10.1002/cncr.28672
doi: 10.1002/cncr.28672
pubmed: 25369213
van der Laan HP, van den Bosch L, Schuit E, Steenbakkers RJHM, van der Schaaf A, Langendijk JA (2021) Impact of radiation-induced toxicities on quality of life of patients treated for head and neck cancer. Radiother Oncol. https://doi.org/10.1016/j.radonc.2021.04.011
doi: 10.1016/j.radonc.2021.04.011
pubmed: 34902370
Trotti A, Colevas AD, Setser A, Rusch V, Jaques D, Budach V et al (2003) CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol. https://doi.org/10.1016/S1053-4296(03)00031-6
doi: 10.1016/S1053-4296(03)00031-6
pubmed: 12903007
Jensen K, Bonde Jensen A, Grau C (2006) The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires. Radiother Oncol. https://doi.org/10.1016/j.radonc.2006.02.005
doi: 10.1016/j.radonc.2006.02.005
pubmed: 16647152
Laugsand EA, Sprangers MAG, Bjordal K, Skorpen F, Kaasa S, Klepstad P (2010) Health care providers underestimate symptom intensities of cancer patients: a multicenter European study. Health Qual Life Outcomes. https://doi.org/10.1186/1477-7525-8-104
doi: 10.1186/1477-7525-8-104
pubmed: 20858248
pmcid: 2949821
Basch E, Deal AM, Dueck AC, Scher HI, Kris MG, Hudis C et al (2017) Overall survival results of a trial assessing patient-reported outcomes for symptom monitoring during routine cancer treatment. JAMA. https://doi.org/10.1001/jama.2017.7156
doi: 10.1001/jama.2017.7156
pubmed: 29164251
pmcid: 5817466
Basch E, Deal AM, Kris MG, Scher HI, Hudis CA, Sabbatini P et al (2016) Symptom monitoring with patient-reported outcomes during routine cancer treatment: a randomized controlled trial. J Clin Oncol. https://doi.org/10.1200/JCO.2015.63.0830
doi: 10.1200/JCO.2015.63.0830
pubmed: 28034065
pmcid: 4872347
Kotronoulas G, Kearney N, Maguire R, Harrow A, di Domenico D, Croy S et al (2014) What is the value of the routine use of patient-reported outcome measures toward improvement of patient outcomes, processes of care, and health service outcomes in cancer care? A systematic review of controlled trials. J Clin Oncol. https://doi.org/10.1200/JCO.2013.53.5948
doi: 10.1200/JCO.2013.53.5948
pubmed: 24711559
Velikova G, Booth L, Smith AB, Brown PM, Lynch P, Brown JM et al (2004) Measuring quality of life in routine oncology practice improves communication and patient well-being: a randomized controlled trial. J Clin Oncol. https://doi.org/10.1200/JCO.2004.06.078
doi: 10.1200/JCO.2004.06.078
pubmed: 14966096
Chera BS, Eisbruch A, Murphy BA, Ridge JA, Gavin P, Reeve BB et al (2014) Recommended patient-reported core set of symptoms to measure in head and neck cancer treatment trials. J Nat Cancer Inst. https://doi.org/10.1093/jnci/dju127
doi: 10.1093/jnci/dju127
pubmed: 25006189
pmcid: 4192043
Ojo B, Genden EM, Teng MS, Milbury K, Misiukiewicz KJ, Badr H (2012) A systematic review of head and neck cancer quality of life assessment instruments. Oral Oncol. https://doi.org/10.1016/j.oraloncology.2012.03.025
doi: 10.1016/j.oraloncology.2012.03.025
pubmed: 22525604
pmcid: 3406264
Bjordal K, Hammerlid E, Ahlner-Elmqvist M, de Graeff A, Boysen M, Evensen JF et al (1999) Quality of life in head and neck cancer patients: Validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H and N35. J Clin Oncol. https://doi.org/10.1200/jco.1999.17.3.1008
doi: 10.1200/jco.1999.17.3.1008
pubmed: 10071296
Holländer-Mieritz C, Johansen J, Johansen C, Vogelius IR, Kristensen CA, Pappot H (2019) Comparing the patients’ subjective experiences of acute side effects during radiotherapy for head and neck cancer with four different patient-reported outcomes questionnaires. Acta Oncol. https://doi.org/10.1080/0284186X.2018.1563713
doi: 10.1080/0284186X.2018.1563713
pubmed: 30698098
D’Antonio LL, Zimmerman GJ, Cella DF, Long SA (1996) Quality of life and functional status measures in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. https://doi.org/10.1001/archotol.1996.01890170018005
doi: 10.1001/archotol.1996.01890170018005
pubmed: 8615964
Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS et al (2007) Measuring head and neck cancer symptom burden: the development and validation of the M.D. Anderson symptom inventory, head and neck module. Head Neck. https://doi.org/10.1002/hed.20602
doi: 10.1002/hed.20602
pubmed: 17358040
Sandler KA, Mitchell SA, Basch E, Raldow AC, Steinberg ML, Sharif J et al (2018) Content validity of anatomic site-specific patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE) item sets for assessment of acute symptomatic toxicities in radiation oncology. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2018.04.048
doi: 10.1016/j.ijrobp.2018.04.048
pubmed: 30312717
pmcid: 6368223
van den Bosch L, van der Laan HP, van der Schaaf A, Oosting SF, Halmos GB, Witjes MJH et al (2021) Patient-reported toxicity and quality of life profiles in head and neck cancer patients treated with definitive radiotherapy or chemoradiation. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2021.05.114
doi: 10.1016/j.ijrobp.2021.05.114
pubmed: 34419564
Bentzen SM, Rosenthal DI, Weymuller EA, Trotti A (2007) Increasing toxicity in nonoperative head and neck cancer treatment: investigations and interventions. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2007.04.080
doi: 10.1016/j.ijrobp.2007.04.080
pubmed: 18037581
pmcid: 2350212
Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS et al (2008) Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. https://doi.org/10.1200/JCO.2007.14.8841
doi: 10.1200/JCO.2007.14.8841
pubmed: 18559875
pmcid: 4911537
Taarnhøj GA, Kennedy FR, Absolom KL, Bæksted C, Vogelius IR, Johansen C et al (2018) Comparison of EORTC QLQ-C30 and PRO-CTCAE
doi: 10.1016/j.jpainsymman.2018.05.017
Tschiesner U, Rogers SN, Harréus U, Berghaus A, Cieza A (2008) Content comparison of quality of life questionnaires used in head and neck cancer based on the international classification of functioning, disability and health: a systematic review. Eur Arch Oto-Rhino-Laryngol. https://doi.org/10.1007/s00405-008-0641-9
doi: 10.1007/s00405-008-0641-9
Jensen J, Hansen CF, Brodersen J, Comins JD, Krogsgaard MR (2020) Are PROMs used adequately in sports research? An analysis of 54 randomized controlled trials with PROMs as endpoint. Scand J Med Sci Sports. https://doi.org/10.1111/sms.13880
doi: 10.1111/sms.13880
pubmed: 33249660
Jensen K, Lambertsen K, Torkov P, Dahl M, Jensen AB, Grau C (2007) Patient assessed symptoms are poor predictors of objective findings. Results from a cross sectional study in patients treated with radiotherapy for pharyngeal cancer. Acta Oncol. https://doi.org/10.1080/02841860701491041
doi: 10.1080/02841860701491041
pubmed: 17917822
Holländer-Mieritz C, Johansen J, Taarnhøj GA, Johansen C, Vogelius IR, Kristensen CA et al (2020) Systematic use of patient reported outcome during radiotherapy for head and neck cancer: study protocol for the national DAHANCA 38 trial. Acta Oncol. https://doi.org/10.1080/0284186X.2020.1725244
doi: 10.1080/0284186X.2020.1725244
pubmed: 32687421