Effects of skin washing frequency on the epidermal barrier function and inflammatory processes of the epidermis: An experimental study.
COVID-19
detergents
hand eczema
hand washing
irritant contact dermatitis
non-invasive measuring methods
occupational
risk assessment
skin barrier
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
21
03
2022
received:
04
11
2021
accepted:
28
03
2022
pubmed:
1
4
2022
medline:
13
8
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Increased hand hygiene measures during the COVID-19 pandemic have led to an increased quantum of hand eczema (HE). To examine the effects of varying washing frequencies using current mild cleansing agents-alongside with the effect of a rehydrating cream-on the epidermal barrier function and inflammatory processes of the stratum corneum(SC). Standardized skin washings on the volar aspects of the lower arms of skin-healthy volunteers were performed using the automated cleansing device either 5 or 11 times within 4 h for 60 s each with a standard cleanser, a lipid-containing syndet, or a lipid-containing syndet followed by one-time application of a rehydrating cream. Skin bioengineering parameters (transepidermal water loss, SC hydration, erythema, and SC pH) and biochemical/immunological parameters (interleukin-1α, interleukin-1α receptor antagonist and natural moisturizing factor) of SCsamples collected by tape stripping were assessed. All applied washing procedures provided comparable, mild effects on the epidermal barrier function and skin inflammation. Occupational skin cleansers seem to have improved regarding skin barrier damaging effects. To further corroborate this, a study design, modified on the basis of our findings, applying longer washing periods for consecutive days seems desirable.
Sections du résumé
BACKGROUND
BACKGROUND
Increased hand hygiene measures during the COVID-19 pandemic have led to an increased quantum of hand eczema (HE).
OBJECTIVES
OBJECTIVE
To examine the effects of varying washing frequencies using current mild cleansing agents-alongside with the effect of a rehydrating cream-on the epidermal barrier function and inflammatory processes of the stratum corneum(SC).
METHODS
METHODS
Standardized skin washings on the volar aspects of the lower arms of skin-healthy volunteers were performed using the automated cleansing device either 5 or 11 times within 4 h for 60 s each with a standard cleanser, a lipid-containing syndet, or a lipid-containing syndet followed by one-time application of a rehydrating cream. Skin bioengineering parameters (transepidermal water loss, SC hydration, erythema, and SC pH) and biochemical/immunological parameters (interleukin-1α, interleukin-1α receptor antagonist and natural moisturizing factor) of SCsamples collected by tape stripping were assessed.
RESULTS
RESULTS
All applied washing procedures provided comparable, mild effects on the epidermal barrier function and skin inflammation.
CONCLUSION
CONCLUSIONS
Occupational skin cleansers seem to have improved regarding skin barrier damaging effects. To further corroborate this, a study design, modified on the basis of our findings, applying longer washing periods for consecutive days seems desirable.
Substances chimiques
Detergents
0
Emollients
0
Interleukin-1alpha
0
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
241-246Subventions
Organisme : Beiersdorf AG
Organisme : Projekt DEAL
Informations de copyright
© 2022 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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