The regional turnover of cartilage collagen matrix in late-stage human knee osteoarthritis.
GC-C-IRMS
Joint
Knee surgery
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
24
11
2021
revised:
03
03
2022
accepted:
22
03
2022
pubmed:
1
4
2022
medline:
20
5
2022
entrez:
31
3
2022
Statut:
ppublish
Résumé
Cartilage collagen has very limited repair potential, though some turnover and incorporation has not been fully excluded. We aim to determine the regional turnover of human osteoarthritis cartilage. Patients scheduled for knee joint replacement surgery due to osteoarthritis were recruited in this prospective study of four weeks duration. Deuterium oxide (D Twenty participants completed the study: mean (SD) age 64 ± 9.1 years, 45% female, BMI 29.5 ± 4.8 kg/m In OA, despite regional differences in gene expression, the turnover of the articular cartilage matrix across the entire joint surface is very limited, but higher turnover was observed in osteophyte cartilage.
Identifiants
pubmed: 35358700
pii: S1063-4584(22)00695-1
doi: 10.1016/j.joca.2022.03.007
pii:
doi:
Substances chimiques
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
886-895Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.