Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?
dry eye
lacrimal functional unit (LFU)
lacrimal gland
ocular surface
oxidative stres
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
29
11
2021
accepted:
16
02
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Oxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated in the pathophysiology, diagnosis and treatment of dry eye disease (DED), even though they comprise a large family of enzymes that includes lactoperoxidase (LPO) and glutathione peroxidase (GPO), among others. Assays to measure and correlate OS with other local LFU phenomena have methodological limitations. Studies implicate molecules and reactions involved in OS as markers of homeostasis, and other studies identify them as part of the physiopathology of diseases. Despite these conflicting concepts and observations, it is clear that OS is influential in the development of DED. Moreover, many antioxidant strategies have been proposed for its treatment, including calorie restriction to nutritional supplementation. This review offers a critical analysis of the biological mechanisms, diagnostic outcomes, drug use, dietary supplements, and life habits that implicate the influence of OS on DED.
Identifiants
pubmed: 35359431
doi: 10.3389/fcell.2022.824726
pii: 824726
pmc: PMC8963457
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
824726Informations de copyright
Copyright © 2022 Lemos, Silva, Faustino, Fantucci, Murashima, Adriano, Alves and Rocha.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Mol Sci. 2020 Nov 10;21(22):
pubmed: 33182758
Br J Ophthalmol. 1984 May;68(5):316-20
pubmed: 6712908
Free Radic Biol Med. 2007 Apr 1;42(7):985-92
pubmed: 17349926
Sci Rep. 2014 Aug 27;4:5772
pubmed: 25159733
Science. 2009 Jul 10;325(5937):201-4
pubmed: 19590001
J Biol Chem. 1969 Nov 25;244(22):6049-55
pubmed: 5389100
N Engl J Med. 2018 May 03;378(18):1681-1690
pubmed: 29652551
Proc Biol Sci. 2009 May 22;276(1663):1737-45
pubmed: 19324792
Graefes Arch Clin Exp Ophthalmol. 2015 Mar;253(3):425-30
pubmed: 25398660
Ocul Surf. 2010 Jan;8(1):18-28
pubmed: 20105404
J Cell Biol. 1976 Sep;70(3):692-706
pubmed: 956271
Arq Bras Oftalmol. 2011 Sep-Oct;74(5):377-81
pubmed: 22184003
J Endocrinol. 2005 Oct;187(1):159-66
pubmed: 16214951
Oxid Med Cell Longev. 2016;2016:4727415
pubmed: 27313829
Ocul Surf. 2018 Apr;16(2):198-205
pubmed: 29510225
Free Radic Res. 2019 May;53(5):497-521
pubmed: 31039624
Curr Eye Res. 2009 Oct;34(10):905-11
pubmed: 19895318
FEMS Microbiol Lett. 1992 Jan 15;69(3):223-8
pubmed: 1555756
Mol Cell Biochem. 2003 Jun;248(1-2):7-16
pubmed: 12870649
Plants (Basel). 2019 Nov 28;8(12):
pubmed: 31795124
PLoS One. 2012;7(9):e45612
pubmed: 23049824
Heliyon. 2019 Jun 15;5(6):e01914
pubmed: 31338452
Curr Eye Res. 2016 Sep;41(9):1143-9
pubmed: 26731289
Biochemistry. 1988 Jan 12;27(1):233-9
pubmed: 3349028
Cornea. 2013 Oct;32(10):1297-304
pubmed: 23884332
Exp Eye Res. 1999 Oct;69(4):355-66
pubmed: 10504269
Ophthalmologica. 2003 Jul-Aug;217(4):294-7
pubmed: 12792137
Invest Ophthalmol Vis Sci. 2014 Jul 03;55(8):5081-9
pubmed: 24994869
Genome Biol. 2006;7(8):R72
pubmed: 16901338
PLoS One. 2010 Mar 29;5(3):e9911
pubmed: 20360971
Eur J Biochem. 1992 May 15;206(1):59-67
pubmed: 1587283
Clin Sci (Lond). 2017 Dec 4;131(24):2865-2883
pubmed: 29203723
Plant Physiol. 2006 Jun;141(2):312-22
pubmed: 16760481
Pediatr Nephrol. 2005 Oct;20(10):1410-5
pubmed: 16079987
Clin Interv Aging. 2016 May 19;11:571-8
pubmed: 27279739
Exp Eye Res. 1985 Feb;40(2):313-20
pubmed: 3979468
J Autoimmun. 2018 Sep;93:45-56
pubmed: 29934134
Arch Oral Biol. 2017 Dec;84:6-12
pubmed: 28926744
Vestn Oftalmol. 2019;135(1):59-66
pubmed: 30830076
Histol Histopathol. 2015 Aug;30(8):893-900
pubmed: 25803192
Histol Histopathol. 2008 Dec;23(12):1477-83
pubmed: 18830933
Arq Bras Oftalmol. 2008 Jan-Feb;71(1):18-21
pubmed: 18408831
Am J Med. 1991 Sep 30;91(3C):31S-38S
pubmed: 1928209
Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):5033-43
pubmed: 22736614
Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10405-9
pubmed: 1332049
Antioxid Redox Signal. 2009 Nov;11(11):2655-71
pubmed: 19558209
Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2781-9
pubmed: 16043851
Invest Ophthalmol Vis Sci. 2015 Jan 08;56(1):538-43
pubmed: 25574043
J Food Sci Technol. 2013 Dec;50(6):1035-46
pubmed: 24426015
J Dent Res. 1994 Feb;73(2):544-55
pubmed: 8120219
Ophthalmology. 2011 Jul;118(7):1242-52
pubmed: 21459453
Acta Physiol Scand. 2002 Feb;174(2):109-15
pubmed: 11860372
Korean J Ophthalmol. 2015 Apr;29(2):131-7
pubmed: 25829831
Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):201-10
pubmed: 23150615
Ophthalmic Res. 2010;44(3):146-54
pubmed: 20829638
Sci Rep. 2016 Apr 18;6:23561
pubmed: 27087247
Acta Ophthalmol Scand. 2003 Dec;81(6):639-45
pubmed: 14641268
Mol Vis. 2012;18:194-202
pubmed: 22312187
Ocul Surf. 2019 Oct;17(4):714-721
pubmed: 31352083
Ocul Surf. 2017 Jul;15(3):284-333
pubmed: 28736336
J Ocul Pharmacol Ther. 2011 Jun;27(3):273-80
pubmed: 21410334
J Biol Chem. 2012 Feb 10;287(7):4403-10
pubmed: 22147704
Clin Interv Aging. 2013;8:139-48
pubmed: 23430672
Ophthalmol Ther. 2019 Mar;8(1):63-73
pubmed: 30565203
Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5582-5
pubmed: 1319066
Mol Vis. 2011 Feb 18;17:533-42
pubmed: 21364905
Int J Mol Sci. 2018 Feb 13;19(2):
pubmed: 29438346
Int J Clin Exp Pathol. 2015 Jun 01;8(6):7644-53
pubmed: 26261685
Int J Biochem Cell Biol. 2007;39(1):44-84
pubmed: 16978905
Mol Vis. 2016 Apr 30;22:446-53
pubmed: 27186071
Cornea. 2011 Jan;30(1):42-9
pubmed: 20861728
Int J Ophthalmol. 2013 Dec 18;6(6):811-6
pubmed: 24392330
Arq Bras Oftalmol. 2016 Feb;79(1):56-61
pubmed: 26840172
Sci Rep. 2017 Dec 12;7(1):17478
pubmed: 29234088
Invest Ophthalmol Vis Sci. 1989 Mar;30(3):562-8
pubmed: 2538403
Curr Opin Ophthalmol. 2015 Nov;26(6):517-25
pubmed: 26367089
Oxid Med Cell Longev. 2017;2017:9281519
pubmed: 29158874
Ocul Surf. 2019 Apr;17(2):257-264
pubmed: 30807830
Histochemistry. 1976 Mar 31;46(4):273-86
pubmed: 4418
Biochim Biophys Acta. 2007 Aug;1770(8):1128-35
pubmed: 17561349
Acta Ophthalmol. 2011 Nov;89(7):e591-7
pubmed: 21834921
Science. 1974 Aug 9;185(4150):529-31
pubmed: 4841157
Nanoscale. 2019 Mar 21;11(12):5580-5594
pubmed: 30860532
Sci Rep. 2016 Nov 11;6:36903
pubmed: 27833152
Arq Bras Oftalmol. 2006 Jul-Aug;69(4):565-70
pubmed: 17119732
Arch Biochem Biophys. 2006 Jan 15;445(2):261-8
pubmed: 16111647
In Vitro Cell Dev Biol. 1987 Jul;23(7):465-73
pubmed: 3610944
J Rheumatol. 2007 Oct;34(10):2035-43
pubmed: 17896802
Endocrine. 2009 Aug;36(1):161-8
pubmed: 19551521
J Infect Dis. 1991 Jul;164(1):8-14
pubmed: 1647427
Hum Gene Ther. 2013 Apr;24(4):417-23
pubmed: 23402345
Arch Gerontol Geriatr. 2004 Nov-Dec;39(3):269-75
pubmed: 15381345
Ann Rheum Dis. 1995 Jun;54(6):505-10
pubmed: 7632097
Free Radic Biol Med. 2016 Aug;97:398-407
pubmed: 27393004
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3343-7
pubmed: 1849652
Biochem J. 1996 Mar 1;314 ( Pt 2):413-9
pubmed: 8670050
Mol Cell Biochem. 1987 Oct;77(2):127-34
pubmed: 3125418
Nature. 2016 Jul 06;535(7610):65-74
pubmed: 27383981
Arch Biochem Biophys. 1990 Jul;280(1):1-8
pubmed: 2191627
Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3038-42
pubmed: 17591870
Clin Immunol Immunopathol. 1995 Sep;76(3 Pt 1):291-6
pubmed: 7554451
Mol Vis. 2015 May 11;21:555-67
pubmed: 25999682
PLoS One. 2018 Jan 5;13(1):e0190355
pubmed: 29304184
Nutrients. 2019 Nov 15;11(11):
pubmed: 31731792
J Fr Ophtalmol. 2011 Sep;34(7):448-55
pubmed: 21696849
Am J Pathol. 2012 May;180(5):1879-96
pubmed: 22440255
Cornea. 2012 Nov;31 Suppl 1:S3-8
pubmed: 23038031
J Histochem Cytochem. 2014 Jan;62(1):85-96
pubmed: 24152995
PLoS One. 2015 Oct 12;10(10):e0139761
pubmed: 26457673
Science. 1966 Jun 17;152(3729):1626-8
pubmed: 4956921
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1286-93
pubmed: 16469299
Free Radic Biol Med. 1993 Apr;14(4):409-20
pubmed: 8468025
Am J Clin Nutr. 1993 May;57(5 Suppl):715S-724S; discussion 724S-725S
pubmed: 8475889
Antioxid Redox Signal. 2007 Mar;9(3):385-91
pubmed: 17184176
Exp Eye Res. 2004 Mar;78(3):409-16
pubmed: 15106920
J Cataract Refract Surg. 2015 Apr;41(4):756-63
pubmed: 25487027
J Ocul Pharmacol. 1991 Fall;7(3):253-8
pubmed: 1783856
Diabetologia. 2005 Dec;48(12):2675-81
pubmed: 16283249
Pathobiology. 2006;73(5):252-60
pubmed: 17314496
Bone Marrow Transplant. 2006 Aug;38(3):223-7
pubmed: 16785864
Trans Ophthalmol Soc U K. 1986;105 ( Pt 1):18-25
pubmed: 3520980
Antioxid Redox Signal. 2008 Jan;10(1):43-9
pubmed: 17949261
Oral Microbiol Immunol. 1992 Oct;7(5):315-20
pubmed: 1494457
Oxid Med Cell Longev. 2015;2015:591530
pubmed: 25861412
Clin Chim Acta. 2005 Mar;353(1-2):133-9
pubmed: 15698600
Arq Bras Oftalmol. 2014 May-Jun;77(3):193-200
pubmed: 25295911
Clin Ophthalmol. 2016 May 09;10:813-20
pubmed: 27274185
Cornea. 2019 Nov;38 Suppl 1:S45-S49
pubmed: 31397734
Fiziol Zh SSSR Im I M Sechenova. 1980 Sep;66(9):1412-7
pubmed: 7418919
J Diabetes Res. 2016;2016:4583742
pubmed: 27478848
Exp Eye Res. 1999 Mar;68(3):265-76
pubmed: 10079134
Biomed Res Int. 2016;2016:6097417
pubmed: 27340664
Clin Exp Immunol. 1989 Dec;78(3):454-9
pubmed: 2558824
Am J Pathol. 2010 Aug;177(2):744-53
pubmed: 20566743
Arch Oral Biol. 2011 Aug;56(8):744-51
pubmed: 21310393
PLoS One. 2016 Aug 12;11(8):e0161041
pubmed: 27517861
Physiol Rev. 2002 Jan;82(1):47-95
pubmed: 11773609
Med Princ Pract. 2013;22(2):131-7
pubmed: 22759590
Ocul Surf. 2008 Oct;6(4):162-74
pubmed: 18827949
Arq Bras Oftalmol. 2015 May-Jun;78(3):158-63
pubmed: 26222104
Infect Immun. 1983 Apr;40(1):70-80
pubmed: 6832837
J Proteomics. 2013 Jan 14;78:94-112
pubmed: 23201116
Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES163-DES168
pubmed: 30481822
J Biol Chem. 1991 Apr 15;266(11):6957-65
pubmed: 1849898
Free Radic Res. 2004 Jul;38(7):739-50
pubmed: 15453639
Proteins. 2008 Aug;72(2):589-605
pubmed: 18247411
Ann Rheum Dis. 2002 Jun;61(6):554-8
pubmed: 12006334
Aust N Z J Psychiatry. 2018 Jul;52(7):690-698
pubmed: 28891319
Curr Eye Res. 1998 Mar;17(3):257-63
pubmed: 9543634
Ocul Surf. 2017 Jul;15(3):575-628
pubmed: 28736343
J Mol Evol. 2000 Nov;51(5):433-45
pubmed: 11080366
Mini Rev Med Chem. 2015;16(3):241-57
pubmed: 26586128
Nutrients. 2018 Oct 19;10(10):
pubmed: 30347752
Endocrine. 2009 Apr;35(2):189-97
pubmed: 19191035
Antioxid Redox Signal. 2008 Jul;10(7):1199-234
pubmed: 18331199
Invest Ophthalmol Vis Sci. 2014 Aug 07;55(9):5813-20
pubmed: 25103264
Exp Eye Res. 2014 Mar;120:1-9
pubmed: 24394592
Oxid Med Cell Longev. 2016;2016:9780193
pubmed: 27635188
Arch Biochem Biophys. 2016 Apr 1;595:33-9
pubmed: 27095212
J Cell Biol. 1972 Jun;53(3):662-80
pubmed: 5028258
Biochem Biophys Res Commun. 2010 Jul 9;397(4):724-8
pubmed: 20537981
Arch Med Res. 2006 Nov;37(8):921-32
pubmed: 17045106
Oxid Med Cell Longev. 2019 Apr 17;2019:4730539
pubmed: 31178961
Exp Eye Res. 2005 Apr;80(4):477-91
pubmed: 15781275
Acta Ophthalmol. 2018 Jun;96(4):e412-e420
pubmed: 28834388
PLoS One. 2012;7(10):e45805
pubmed: 23071526
Genome Biol. 2006;7(9):R80
pubmed: 16948836
Arthritis Rheum. 1984 Apr;27(4):459-61
pubmed: 6712760
Ophthalmic Res. 2002 Jul-Aug;34(4):251-3
pubmed: 12297698
Arq Bras Oftalmol. 2008 Nov-Dec;71(6 Suppl):72-9
pubmed: 19274416
Am J Clin Nutr. 2003 Sep;78(3):361-9
pubmed: 12936916
Histochemie. 1972;30(3):235-46
pubmed: 4342227
J Oral Pathol Med. 2014 Jan;43(1):61-8
pubmed: 23701528
Redox Biol. 2015;4:180-3
pubmed: 25588755