From Mice to Men: Generation of Human Blastocyst-Like Structures
blastoids
embryonic development
human blastocyst-like structures
implantation
pluripotent stem cells
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
12
2021
accepted:
26
01
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Advances in the field of stem cell-based models have in recent years lead to the development of blastocyst-like structures termed blastoids. Blastoids can be used to study key events in mammalian pre-implantation development, as they mimic the blastocyst morphologically and transcriptionally, can progress to the post-implantation stage and can be generated in large numbers. Blastoids were originally developed using mouse pluripotent stem cells, and since several groups have successfully generated blastocyst models of the human system. Here we provide a comparison of the mouse and human protocols with the aim of deriving the core requirements for blastoid formation, discuss the models' current ability to mimic blastocysts and give an outlook on potential future applications.
Identifiants
pubmed: 35359453
doi: 10.3389/fcell.2022.838356
pii: 838356
pmc: PMC8963787
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
838356Informations de copyright
Copyright © 2022 Luijkx, Shankar, van Blitterswijk, Giselbrecht and Vrij.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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