Comprehensive Analysis of the Differential Expression and Prognostic Value of Histone Deacetylases in Glioma.
CGGA, Chinese Glioma Genome Atlas
HDACs
bioinformatics analysis
biomarker
glioma
immune infiltration
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
12
2021
accepted:
31
01
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Gliomas are the most common and aggressive malignancies of the central nervous system. Histone deacetylases (HDACs) are important targets in cancer treatment. They regulate complex cellular mechanisms that influence tumor biology and immunogenicity. However, little is known about the function of HDACs in glioma. The Oncomine, Human Protein Atlas, Gene Expression Profiling Interactive Analysis, Broad Institute Cancer Cell Line Encyclopedia, Chinese Glioma Genome Atlas, OmicShare, cBioPortal, GeneMANIA, STRING, and TIMER databases were utilized to analyze the differential expression, prognostic value, and genetic alteration of HDAC and immune cell infiltration in patients with glioma.
Identifiants
pubmed: 35359455
doi: 10.3389/fcell.2022.840759
pii: 840759
pmc: PMC8961059
doi:
Types de publication
Journal Article
Langues
eng
Pagination
840759Informations de copyright
Copyright © 2022 Li, Yan, Liang, Chen, Liu, Wu, Zheng, Dang, La and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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