Clinical and Instrumental Characterization of Patients With Late-Onset Epilepsy.
Alzheimer's disease
brain MRI
cerebrospinal fluid
computed tomography
electroencephalography
late-onset epilepsy
neuropsychology
positron emission tomography
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
01
2022
accepted:
04
02
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Epilepsy is classically considered a childhood disease. However, it represents the third most frequent neurological condition in the elderly, following stroke, and dementia. With the progressive aging of the general population, the number of patients with Late-Onset Epilepsy (LOE) is constantly growing, with important economic and social consequences, in particular for the more developed countries where the percentage of elderly people is higher. The most common causes of LOE are structural, mainly secondary to cerebrovascular or infectious diseases, brain tumors, trauma, and metabolic or toxic conditions. Moreover, there is a growing body of evidence linking LOE with neurodegenerative diseases, particularly Alzheimer's disease (AD). However, despite a thorough characterization, the causes of LOE remain unknown in a considerable portion of patients, thus termed as Late-Onset Epilepsy of Unknown origin (LOEU). In order to identify the possible causes of the disease, with an important impact in terms of treatment and prognosis, LOE patients should always undergo an exhaustive phenotypic characterization. In this work, we provide a detailed review of the main clinical and instrumental techniques for the adequate characterization of LOE patients in the clinical practice. This work aims to provide an easy and effective tool that supports routine activity of the clinicians facing LOE.
Identifiants
pubmed: 35359649
doi: 10.3389/fneur.2022.851897
pmc: PMC8963711
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
851897Informations de copyright
Copyright © 2022 DiFrancesco, Labate, Romoli, Chipi, Salvadori, Galimberti, Perani, Ferrarese and Costa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Epilepsy Res. 2006 Dec;72(2-3):89-96
pubmed: 16930944
CNS Drugs. 2003;17(14):1013-30
pubmed: 14594442
Alzheimers Dement. 2019 Aug;15(8):1081-1103
pubmed: 31230910
Epilepsia. 1999 Aug;40(8):1100-2
pubmed: 10448822
Epilepsia. 2006 Dec;47(12):1990-8
pubmed: 17201695
Epileptic Disord. 2021 Oct 1;23(5):675-681
pubmed: 34526291
Clin Neuropsychol. 2013;27(7):1077-105
pubmed: 24016131
Epilepsy Behav. 2019 Feb;91:75-80
pubmed: 29941211
Epilepsy Behav. 2019 Oct;99:106478
pubmed: 31481308
Epilepsy Behav. 2021 Sep;122:108204
pubmed: 34311181
Epilepsy Res. 2007 May;74(2-3):91-6
pubmed: 17368001
Neurology. 2021 Nov 2;97(18):e1809-e1822
pubmed: 34531298
Front Neurol. 2020 Apr 15;11:199
pubmed: 32351438
Epilepsy Res. 1998 Nov;32(3):357-62
pubmed: 9839775
J Am Coll Cardiol. 2002 Jul 3;40(1):142-8
pubmed: 12103268
Clin Infect Dis. 2015 Apr 15;60(8):1162-9
pubmed: 25663160
Epilepsy Behav. 2005 Dec;7(4):708-14
pubmed: 16266826
Seizure. 2006 Jun;15(4):227-34
pubmed: 16563807
J Neurol Sci. 1996 Oct;142(1-2):54-8
pubmed: 8902720
J Alzheimers Dis. 2014;41(1):113-27
pubmed: 24577480
Neurophysiol Clin. 2010 Nov-Dec;40(5-6):249-54
pubmed: 21093796
Neurology. 2007 Nov 6;69(19):1823-7
pubmed: 17984449
Epilepsia. 1996 Feb;37(2):162-4
pubmed: 8635426
J Neuroimaging. 2013 Jan;23(1):129-31
pubmed: 21223436
J Neurol. 2004 Jun;251(6):704-9
pubmed: 15311346
Epilepsia. 2010 Jan;51(1):48-56
pubmed: 19583779
Epilepsia. 2004 Mar;45(3):263-7
pubmed: 15009228
Neurology. 2010 Feb 16;74(7):553-7
pubmed: 20089943
Epilepsia. 2010 Apr;51(4):671-5
pubmed: 19732133
Semin Nucl Med. 2015 May;45(3):224-33
pubmed: 25841277
Curr Opin Neurol. 2018 Apr;31(2):223-231
pubmed: 29389747
Epileptic Disord. 2020 Aug 1;22(4):421-437
pubmed: 32763869
Seizure. 2015 Mar;26:65-8
pubmed: 25799904
Eur J Neurol. 2005 Aug;12(8):575-81
pubmed: 16053464
Neurobiol Aging. 2019 Jan;73:61-67
pubmed: 30317034
Neurology. 2006 Feb 28;66(4):562-5
pubmed: 16505312
Exp Neurol. 2013 Jun;244:11-21
pubmed: 21985866
Epilepsia. 2019 Jun;60(6):1054-1068
pubmed: 31135062
Epilepsy Res. 2006 Jan;68 Suppl 1:S39-48
pubmed: 16384689
Clin Electroencephalogr. 1999 Oct;30(4):126-31
pubmed: 10513317
Epilepsy Behav. 2021 Apr;117:107839
pubmed: 33611099
Ann Clin Transl Neurol. 2020 Aug;7(8):1392-1399
pubmed: 32710704
J Clin Neurophysiol. 2011 Aug;28(4):388-93
pubmed: 21811129
Lancet Neurol. 2009 Apr;8(4):370-81
pubmed: 19296920
J Alzheimers Dis. 2021 Nov 22;:
pubmed: 34842184
Nat Rev Neurol. 2021 Aug;17(8):469-485
pubmed: 34117482
J Int Neuropsychol Soc. 2007 Jan;13(1):12-20
pubmed: 17166299
Epilepsy Behav. 2006 Feb;8(1):161-8
pubmed: 16266829
JAMA Neurol. 2015 Aug;72(8):882-8
pubmed: 26052981
Eur J Nucl Med Mol Imaging. 2021 Dec;49(1):221-233
pubmed: 34120191
Brain. 2018 Aug 1;141(8):e60
pubmed: 29893897
Clin Neurophysiol. 2015 Aug;126(8):1498-504
pubmed: 25487912
Curr Opin Neurol. 2018 Aug;31(4):371-378
pubmed: 29782369
Scand J Infect Dis. 2013 Sep;45(9):657-63
pubmed: 23808722
Ann Neurol. 2018 Aug;84(2):302-314
pubmed: 30014515
Electroencephalogr Clin Neurophysiol. 1998 Apr;106(4):369-73
pubmed: 9741765
Epilepsia. 2005 Feb;46(2):298-303
pubmed: 15679511
Epilepsia. 2002 Feb;43(2):165-9
pubmed: 11903463
Neuroepidemiology. 2018;51(3-4):216-223
pubmed: 30253417
Epilepsy Behav. 2019 Dec;101(Pt A):106592
pubmed: 31726425
J Neurol. 2021 Dec;268(12):4789-4795
pubmed: 33991241
Nat Med. 2020 Feb;26(2):281-288
pubmed: 31959988
Epilepsia. 1970 Dec;11(4):361-81
pubmed: 5278205
Seizure. 2017 Jul;49:83-89
pubmed: 28284559
Epilepsia. 1986 Jul-Aug;27(4):458-63
pubmed: 3720706
Drug Alcohol Depend. 2013 Dec 15;133(3):795-804
pubmed: 24051062
Epilepsy Behav. 2011 Sep;22(1):69-76
pubmed: 21795122
Neuroscience. 2016 Mar 1;316:143-50
pubmed: 26724581
Ann Neurol. 2016 Dec;80(6):858-870
pubmed: 27696483
Epilepsy Res. 2018 Feb;140:90-94
pubmed: 29310076
Epilepsia. 1993 May-Jun;34(3):453-68
pubmed: 8504780
Epilepsia. 1991 May-Jun;32(3):358-64
pubmed: 1904345
Neurol Clin. 2002 Feb;20(1):227-39, vii
pubmed: 11754308
Neurology. 2007 Oct 30;69(18):1772-80
pubmed: 17967993
Clin Nucl Med. 2017 Oct;42(10):768-769
pubmed: 28806243
Epilepsia. 2015 May;56(5):674-81
pubmed: 25779625
Epilepsy Behav. 2016 Mar;56:113-7
pubmed: 26859320
Epilepsia. 2011 May;52(5):949-56
pubmed: 21275976
Clin Neurol Neurosurg. 2020 Nov;198:106209
pubmed: 32987311
Acta Neurol Scand. 2014 Sep;130(3):172-7
pubmed: 24796793
Seizure. 2002 Jun;11(4):269-72
pubmed: 12027576
Neurol Sci. 2019 Oct;40(10):2017-2030
pubmed: 31161339
Lancet Neurol. 2017 Apr;16(4):311-322
pubmed: 28327340
J Neurol. 2012 Aug;259(8):1727-31
pubmed: 22580844
Neuroradiol J. 2011 May 15;24(2):253-7
pubmed: 24059616
J Neuroimmunol. 2006 Apr;173(1-2):188-95
pubmed: 16483671
J Alzheimers Dis. 2017;60(4):1267-1274
pubmed: 28968234
N Engl J Med. 2018 Mar 1;378(9):840-851
pubmed: 29490181
Pharmacol Res. 2016 Apr;106:21-26
pubmed: 26896787
Epilepsia. 2020 May;61(5):924-934
pubmed: 32311085
AJNR Am J Neuroradiol. 2013 Aug;34(8):1585-8
pubmed: 23449653
Lancet. 2019 Feb 16;393(10172):689-701
pubmed: 30686584
Epilepsia. 2020 Oct;61(10):2183-2193
pubmed: 32944949
Neurobiol Aging. 2016 Dec;48:161-171
pubmed: 27701029
Brain. 2018 Jun 1;141(6):1592-1608
pubmed: 29506031
Handb Clin Neurol. 2012;107:437-59
pubmed: 22938988
Epilepsy Res. 2017 Jul;133:22-27
pubmed: 28407518