RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study.
LVEF
RNA
cancer
cardiomyopathy
chemotherapy
immune suppression
infection
virus
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
11
2021
accepted:
20
01
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown. An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function. High-throughput sequencing of RNA isolated from blood samples was analyzed following chemotherapy for hematological malignancies ( On initial rigorous analysis, low levels of influenza orthomyxovirus and avian paramyxovirus sequences were detectable, but without significant correlation to LVEF (r = 0.208). A secondary broad data mining analysis for virus sequences, without filtering human sequences, detected significant correlations for paramyxovirus with LVEF after chemotherapy (r = 0.592, This is the first report of RNA virus screening in circulating blood and association with changes in cardiac function among patients post chemotherapy, using unbiased, blinded, high-throughput sequencing. Influenza orthomyxovirus, avian paramyxovirus and retrovirus sequences were detectable in patients with reduced LVEF. Further analysis for RNA virus infections in patients with cardiomyopathy after chemotherapy is warranted.
Sections du résumé
Background
UNASSIGNED
Viral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.
Objective
UNASSIGNED
An unbiased, blinded screening for RNA viruses was performed after chemotherapy with correlation to cardiac function.
Methods
UNASSIGNED
High-throughput sequencing of RNA isolated from blood samples was analyzed following chemotherapy for hematological malignancies (
Results
UNASSIGNED
On initial rigorous analysis, low levels of influenza orthomyxovirus and avian paramyxovirus sequences were detectable, but without significant correlation to LVEF (r = 0.208). A secondary broad data mining analysis for virus sequences, without filtering human sequences, detected significant correlations for paramyxovirus with LVEF after chemotherapy (r = 0.592,
Conclusions
UNASSIGNED
This is the first report of RNA virus screening in circulating blood and association with changes in cardiac function among patients post chemotherapy, using unbiased, blinded, high-throughput sequencing. Influenza orthomyxovirus, avian paramyxovirus and retrovirus sequences were detectable in patients with reduced LVEF. Further analysis for RNA virus infections in patients with cardiomyopathy after chemotherapy is warranted.
Identifiants
pubmed: 35360008
doi: 10.3389/fcvm.2022.821162
pmc: PMC8962958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
821162Informations de copyright
Copyright © 2022 Varkoly, Tan, Beladi, Fonseca, Zanetti, Kraberger, Shah, Yaron, Zhang, Juby, Fath, Ambadapadi, House, Maranian, Pepine, Varsani, Moreb, Schultz-Cherry and Lucas.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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