Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases.
CD39
CD73
biliary cancers
hypoxia
immune suppression
pancreatic cancer
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
01
2022
accepted:
03
02
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways. The cellular processes linked to extracellular purinergic signaling are crucial in the initiation, evolution, and resolution of inflammation. Injured or dying cells in the pancreatobiliary tract secrete or release ATP, which results in sustained purinergic signaling mediated through ATP type-2 purinergic receptors (P2R). This process can result in chronic inflammation, fibrosis, and tumor development. In contrast, signaling
Identifiants
pubmed: 35360246
doi: 10.3389/fphys.2022.849258
pmc: PMC8964054
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
849258Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK122796
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133900
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL154720
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM135118
Pays : United States
Informations de copyright
Copyright © 2022 Faraoni, Ju, Robson, Eltzschig and Bailey-Lundberg.
Déclaration de conflit d'intérêts
SCR is a scientific founder of Purinomia Biotech Inc and has consulted for eGenesis. AbbVie and SynLogic Inc; his interests are reviewed and managed by HMFP and Beth Israel Deaconess Medical Center in accordance with the conflict-of-interest policies. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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