Impact of gastrointestinal differences in veterinary species on the oral drug solubility, in vivo dissolution, and formulation of veterinary therapeutics.
formulation considerations
gastrointestinal physiology
solubility
veterinary
Journal
ADMET & DMPK
ISSN: 1848-7718
Titre abrégé: ADMET DMPK
Pays: Croatia
ID NLM: 101660124
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
10
2021
revised:
19
12
2021
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
2
4
2022
Statut:
epublish
Résumé
Many gaps exist in our understanding of species differences in gastrointestinal (GI) fluid composition and the associated impact of food intake and dietary composition on in vivo drug solubilization. This information gap can lead to uncertainties with regard to how best to formulate pharmaceuticals for veterinary use or the in vitro test conditions that will be most predictive of species-specific in vivo oral product performance. To address these challenges, this overview explores species-specific factors that can influence oral drug solubility and the formulation approaches that can be employed to overcome solubility-associated bioavailability difficulties. These discussions are framed around some of the basic principles associated with drug solubilization, reported species differences in GI fluid composition, types of oral dosage forms typically given for the various animal species, and the effect of prandial state in dogs and cats. This basic information is integrated into a question-and-answer section that addresses some of the formulation issues that can arise in the development of veterinary medicinals.
Identifiants
pubmed: 35360673
doi: 10.5599/admet.1140
pmc: PMC8963575
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1-25Informations de copyright
Copyright © 2022 by the authors.
Déclaration de conflit d'intérêts
Conflict of interest : Dr. MN Martinez, R Fahmy, and MG Papich have no conflicts of interest to declare.
Références
Vet Dermatol. 2015 Oct;26(5):334-8, e70-1
pubmed: 26216025
Eur J Pharm Biopharm. 2000 Mar;49(2):99-102
pubmed: 10704891
Gastroenterology. 1967 Jan;52(1):29-34
pubmed: 5335073
Am J Vet Res. 2000 Mar;61(3):310-5
pubmed: 10714524
J Vet Pharmacol Ther. 2002 Aug;25(4):265-72
pubmed: 12213114
J Vet Intern Med. 1997 Nov-Dec;11(6):361-4
pubmed: 9470162
Equine Vet J. 2020 Sep;52(5):643-650
pubmed: 32748990
Eur J Pharm Biopharm. 2019 Mar;136:221-230
pubmed: 30703546
Laryngoscope. 1983 Feb;93(2):184-7
pubmed: 6823189
AAPS J. 2017 May;19(3):712-726
pubmed: 28265981
J Anim Physiol Anim Nutr (Berl). 2005 Apr-Jun;89(3-6):189-93
pubmed: 15787993
Mol Pharm. 2021 Apr 5;18(4):1699-1710
pubmed: 33720733
J Vet Pharmacol Ther. 1992 Jun;15(2):160-73
pubmed: 1433478
J Vet Intern Med. 2019 Mar;33(2):961-967
pubmed: 30768821
J Pharm Sci. 1997 Oct;86(10):1148-55
pubmed: 9344173
AAPS PharmSciTech. 2005 Sep 20;6(1):E120-6
pubmed: 16353956
J Vet Pharmacol Ther. 2004 Jun;27(3):155-62
pubmed: 15189301
J Vet Intern Med. 2017 Jul;31(4):1163-1169
pubmed: 28627123
Aust Vet J. 1973 Oct;49(10):460-2
pubmed: 4774387
J Feline Med Surg. 2021 Dec 8;:1098612X211062096
pubmed: 34878315
J Equine Vet Sci. 2018 May;64:59-64
pubmed: 30973154
Toxicol Pathol. 2003 Jan-Feb;31 Suppl:17-24
pubmed: 12597427
Pharm Res. 1986 Jun;3(3):123-31
pubmed: 24271517
J Control Release. 2015 Dec 28;220(Pt A):71-78
pubmed: 26476174
Equine Vet J. 1998 Jul;30(4):349-51
pubmed: 9705120
J Vet Intern Med. 2021 Mar;35(2):887-891
pubmed: 33586200
Eur J Pharm Sci. 1998 Apr;6(2):131-9
pubmed: 9795031
Front Pharmacol. 2018 Nov 08;9:1283
pubmed: 30467479
Int J Pharm. 2006 Sep 14;321(1-2):1-11
pubmed: 16920290
Eur J Pharm Biopharm. 2020 Sep;154:116-126
pubmed: 32580049
Pharmaceutics. 2020 Sep 03;12(9):
pubmed: 32899235
J Gen Physiol. 1990 May;95(5):1007-18
pubmed: 2362181
Pharm Res. 2002 Jul;19(7):921-5
pubmed: 12180542
J Vet Pharmacol Ther. 2006 Oct;29(5):379-85
pubmed: 16958782
J Nutr. 2006 Jul;136(7 Suppl):1932S-1934S
pubmed: 16772462
Dose Response. 2020 Mar 4;18(1):1559325820908980
pubmed: 32180688
Biopharm Drug Dispos. 1995 Jul;16(5):351-80
pubmed: 8527686
J Vet Intern Med. 2017 Sep;31(5):1508-1513
pubmed: 28771831
AAPS J. 2021 Apr 27;23(3):59
pubmed: 33907906
Animals (Basel). 2019 Oct 19;9(10):
pubmed: 31635105
Adv Drug Deliv Rev. 2007 Jul 30;59(7):603-16
pubmed: 17619064
Drug Dev Ind Pharm. 1998 Apr;24(4):389-94
pubmed: 9876600
J Vet Pharmacol Ther. 2016 Feb;39(1):78-83
pubmed: 25989292
J Vet Pharmacol Ther. 2006 Dec;29(6):459-67
pubmed: 17083449
Eur J Pharm Sci. 2020 Dec 1;155:105535
pubmed: 32877722
J Vet Pharmacol Ther. 1996 Aug;19(4):305-11
pubmed: 8866460
Eur Surg Res. 1980;12(4):270-82
pubmed: 7250155
Adv Drug Deliv Rev. 2004 Jun 23;56(10):1399-413
pubmed: 15191789
J Pharm Sci. 2009 Jul;98(7):2494-500
pubmed: 19177514
Anat Histol Embryol. 2009 Nov;38(6):455-60
pubmed: 19860748
J Am Vet Med Assoc. 2018 Jan 15;252(2):195-200
pubmed: 29319446
J Pharm Pharmacol. 2001 Jan;53(1):33-9
pubmed: 11206190
J Vet Intern Med. 2005 May-Jun;19(3):303-14
pubmed: 15954543
J Pharm Pharmacol. 2019 Apr;71(4):557-580
pubmed: 30203429
AAPS PharmSciTech. 2017 May;18(4):1408-1416
pubmed: 27600321
Am J Vet Res. 2003 Sep;64(9):1105-9
pubmed: 13677387
Am J Vet Res. 2012 Jul;73(7):1085-91
pubmed: 22738062
AAPS J. 2015 Jul;17(4):948-64
pubmed: 25916691
Am J Vet Res. 2006 Feb;67(2):342-7
pubmed: 16454643
J Pharm Pharm Sci. 2018;21(1s):254s-270s
pubmed: 30348249
Am J Vet Res. 2019 Oct;80(10):957-962
pubmed: 31556716
Res Vet Sci. 1994 Mar;56(2):164-9
pubmed: 8191005
J Nutr. 2006 Jul;136(7 Suppl):1927S-1931S
pubmed: 16772461
J Vet Intern Med. 2017 Sep;31(5):1414-1419
pubmed: 28833548
J Pharm Sci. 2002 Aug;91(8):1743-64
pubmed: 12115803
J Am Vet Med Assoc. 2003 Feb 15;222(4):423-4
pubmed: 12597408
J Vet Pharmacol Ther. 2012 Apr;35 Suppl 1:93-7
pubmed: 22413796
Clin Pharmacokinet. 2016 Jun;55(6):673-96
pubmed: 26895020
Equine Vet J. 2012 Jul;44(4):482-6
pubmed: 22296404