Defining the risk of SARS-CoV-2 variants on immune protection.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
25
11
2021
accepted:
24
03
2022
pubmed:
2
4
2022
medline:
28
5
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
The global emergence of many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants jeopardizes the protective antiviral immunity induced after infection or vaccination. To address the public health threat caused by the increasing SARS-CoV-2 genomic diversity, the National Institute of Allergy and Infectious Diseases within the National Institutes of Health established the SARS-CoV-2 Assessment of Viral Evolution (SAVE) programme. This effort was designed to provide a real-time risk assessment of SARS-CoV-2 variants that could potentially affect the transmission, virulence, and resistance to infection- and vaccine-induced immunity. The SAVE programme is a critical data-generating component of the US Government SARS-CoV-2 Interagency Group to assess implications of SARS-CoV-2 variants on diagnostics, vaccines and therapeutics, and for communicating public health risk. Here we describe the coordinated approach used to identify and curate data about emerging variants, their impact on immunity and effects on vaccine protection using animal models. We report the development of reagents, methodologies, models and notable findings facilitated by this collaborative approach and identify future challenges. This programme is a template for the response to rapidly evolving pathogens with pandemic potential by monitoring viral evolution in the human population to identify variants that could reduce the effectiveness of countermeasures.
Identifiants
pubmed: 35361968
doi: 10.1038/s41586-022-04690-5
pii: 10.1038/s41586-022-04690-5
pmc: PMC9345323
mid: NIHMS1824978
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
640-652Subventions
Organisme : NIAID NIH HHS
ID : R01 AI157155
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI153602
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI068618
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI060699
Pays : United States
Organisme : NIAID NIH HHS
ID : R24 AI120942
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00014
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00051
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019D00025
Pays : United States
Organisme : Bill & Melinda Gates Foundation
ID : INV-001650
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI135995
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI154470
Pays : United States
Organisme : NCI NIH HHS
ID : 75N91019D00024
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI150747
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007524
Pays : United States
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134907
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00017
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120997
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI141990
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AI005156
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057266
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260476
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151810
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI080289
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00076
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400006C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI042790
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00016
Pays : United States
Organisme : NIH HHS
ID : S10 OD026880
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146785
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI144616
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129269
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00050
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201800013C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136514
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141707
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI148378
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700060C
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400007C
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI143639
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00052
Pays : United States
Informations de copyright
© 2022. Springer Nature Limited.
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