Two-year follow-up of infant and maternal outcomes after planned early delivery or expectant management for late preterm pre-eclampsia (PHOENIX): A randomised controlled trial.
delivery
infant
neurodevelopment
pre-eclampsia
preterm
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
revised:
08
02
2022
received:
03
08
2021
accepted:
12
02
2022
pubmed:
2
4
2022
medline:
12
8
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
We evaluated the best time to initiate delivery in late preterm pre-eclampsia in order to optimise long-term infant and maternal outcomes. Parallel-group, non-masked, randomised controlled trial. Forty-six maternity units in the UK. Women with pre-eclampsia between 34 Infant neurodevelopmental outcome at 2 years of age, using the Parent Report of Children's Abilities - Revised (PARCA-R) composite score. Between 29 September 2014 and 10 December 2018, 901 women were enrolled in the trial, with 450 women allocated to planned delivery and 451 women allocated to expectant management. At the 2-year follow-up, the intention-to-treat analysis population included 276 women (290 infants) allocated to planned delivery and 251 women (256 infants) allocated to expectant management. The mean composite standardised PARCA-R scores were 89.5 (SD 18.2) in the planned delivery group and 91.9 (SD 18.4) in the expectant management group, with an adjusted mean difference of -2.4 points (95% CI -5.4 to 0.5 points). In infants of women with late preterm pre-eclampsia, the average neurodevelopmental assessment at 2 years lies within the normal range, regardless of whether planned delivery or expectant management was pursued. With the lower than anticipated follow-up rate there was limited power to demonstrate that these scores did not differ, but the small between-group difference in PARCA-R scores is unlikely to be clinically important.
Identifiants
pubmed: 35362666
doi: 10.1111/1471-0528.17167
pmc: PMC9545311
doi:
Banques de données
ISRCTN
['ISRCTN01879376']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
1654-1663Subventions
Organisme : Health Technology Assessment Programme
ID : 12/25/03
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd.
Références
Lancet. 2019 Sep 28;394(10204):1181-1190
pubmed: 31472930
BMJ Open. 2016 Jul 07;6(7):e010884
pubmed: 27388354
Lancet Glob Health. 2014 Jun;2(6):e323-33
pubmed: 25103301
Trials. 2020 Nov 23;21(1):960
pubmed: 33228794
J Obstet Gynecol Neonatal Nurs. 2012 Nov-Dec;41(6):E62-70
pubmed: 22861382
J Pediatr. 2009 Feb;154(2):169-76
pubmed: 19081113
Wellcome Open Res. 2017 Oct 17;2:101
pubmed: 29387801
BJOG. 2020 Nov;127(12):1516-1526
pubmed: 32416644
BJOG. 2022 Sep;129(10):1654-1663
pubmed: 35362666
Semin Perinatol. 2009 Jun;33(3):130-7
pubmed: 19464502
Eur J Obstet Gynecol Reprod Biol. 2020 Jan;244:172-179
pubmed: 31810023
BMJ. 2009 Jan 15;338:a3045
pubmed: 19147636
Am J Obstet Gynecol. 2019 Aug;221(2):154.e1-154.e11
pubmed: 30940558
BMJ. 2019 Jul 15;366:l2381
pubmed: 31307997
Am J Obstet Gynecol. 2011 Oct;205(4):374.e1-9
pubmed: 21864824
Eur J Obstet Gynecol Reprod Biol. 2008 Jan;136(1):34-8
pubmed: 17434250
Arch Dis Child Fetal Neonatal Ed. 2015 Jul;100(4):F301-8
pubmed: 25834170
BMJ. 2010 Dec 21;341:c7087
pubmed: 21177352
Med Care. 1996 Mar;34(3):220-33
pubmed: 8628042
Lancet. 2017 Apr 29;389(10080):1719-1729
pubmed: 28341515
BMC Public Health. 2016 Aug 18;16(1):818
pubmed: 27538506
Cochrane Database Syst Rev. 2017 Jan 15;1:CD009273
pubmed: 28106904
Lancet. 2011 Jan 15;377(9761):219-27
pubmed: 21185591
Lancet Child Adolesc Health. 2019 Oct;3(10):705-712
pubmed: 31402196
Pregnancy Hypertens. 2018 Jul;13:291-310
pubmed: 29803330
Lancet. 2021 Jul 24;398(10297):341-354
pubmed: 34051884
Am J Obstet Gynecol. 2012 May;206(5):406.e1-7
pubmed: 22444791
Semin Perinatol. 2014 Apr;38(3):151-8
pubmed: 24836827
Trials. 2019 Jan 28;20(1):85
pubmed: 30691508
Fertil Steril. 2015 Jul;104(1):188-95.e1
pubmed: 25956365
J Glob Health. 2018 Dec;8(2):020401
pubmed: 30140431
Am J Obstet Gynecol. 2007 Oct;197(4):406.e1-7
pubmed: 17904980
J Pediatr. 2018 Feb;193:85-92.e1
pubmed: 29254758
BMJ Open. 2011 May 24;1(1):e000101
pubmed: 22021762
N Engl J Med. 2008 Jul 17;359(3):262-73
pubmed: 18635431