Menstrual Symptoms, Health-Related Quality of Life, and Work Productivity in Japanese Women with Dysmenorrhea Receiving Different Treatments: Prospective Observational Study.
Dysmenorrhea
Health-Related Quality of Life
LEP
Menstrual Symptoms
PRO/QOL: Trial Based
Women’s Health
Work Productivity
Journal
Advances in therapy
ISSN: 1865-8652
Titre abrégé: Adv Ther
Pays: United States
ID NLM: 8611864
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
12
01
2022
accepted:
07
03
2022
pubmed:
2
4
2022
medline:
25
5
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
Dysmenorrhea is a physical and mental burden for women, negatively affecting health-related quality of life (HRQL) and work productivity. However, data on HRQL and work productivity of Japanese women are scarce. In this prospective observational study, 397 Japanese women received low-dose estrogen/progestin (LEP) or non-LEP treatment (non-steroidal anti-inflammatory drugs or Chinese herbal medicines) for primary/secondary dysmenorrhea and completed survey questionnaires online regarding menstrual symptoms, HRQL, and work productivity. Regression analysis was performed to compare the groups and evaluate outcomes over time using the paired t test. Subgroup analysis was performed using stratification by patient background, and correlations between improvement in menstrual symptoms/HRQL and work productivity were investigated using Spearman's rank correlation coefficient. Significant reductions in the modified Menstrual Distress Questionnaire (mMDQ) total score were shown in the LEP group (n = 251) (P < 0.01), but not the non-LEP group (n = 146). Significant improvements in HRQL, measured by the 36-Item Short-Form Health Survey v2.0 (SF-36v2.0), were shown in the LEP group, but not the non-LEP group. Improvements were seen in mental component summary and 7/8 domains (role physical, bodily pain, general health, role emotional, mental health, vitality, and social functioning) in the LEP group, but not the non-LEP group. There were no differences in the physical component summary and role functioning in either group. Improvements in work productivity, measured by the modified Work Productivity and Activity Impairment Questionnaire (mWPAI), were greater in the LEP group vs. non-LEP group. Regression analysis showed differences in improvements between the groups in the mMDQ total score, SF-36v2.0, and mWPAI. A correlation between mMDQ or HRQL and work productivity was seen. In Japanese women, dysmenorrhea is associated with reduced HRQL and work productivity. In real-world clinical practice, improvements in physical and mental menstrual symptoms, HRQL, and work productivity were observed with LEP treatment. NCT04607382 (ClinicalTrials.gov).
Identifiants
pubmed: 35362862
doi: 10.1007/s12325-022-02118-0
pii: 10.1007/s12325-022-02118-0
pmc: PMC9123075
doi:
Banques de données
ClinicalTrials.gov
['NCT04607382']
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
2562-2577Informations de copyright
© 2022. The Author(s).
Références
Ju H, Jones M, Mishra G. The prevalence and risk factors of dysmenorrhea. Epidemiol Rev. 2014;36:104–13.
doi: 10.1093/epirev/mxt009
Chen CX, Draucker CB, Carpenter JS. What women say about their dysmenorrhea: a qualitative thematic analysis. BMC Womens Health. 2018;18:47.
doi: 10.1186/s12905-018-0538-8
Proctor M, Farquhar C. Diagnosis and management of dysmenorrhoea. BMJ. 2006;332:1134–8.
doi: 10.1136/bmj.332.7550.1134
Iacovides S, Avidon I, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015;21:762–8.
doi: 10.1093/humupd/dmv039
Nagy H, Khan MAB. Dysmenorrhea. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK560834/ . 2021. Accessed Aug 31, 2021.
Tanaka E, Momoeda M, Osuga Y, et al. Burden of menstrual symptoms in Japanese women: results from a survey-based study. J Med Econ. 2013;16:1255–66.
doi: 10.3111/13696998.2013.830974
Osuga Y, Hayashi K, Kobayashi Y, et al. Dysmenorrhea in Japanese women. Int J Gynaecol Obstet. 2005;88:82–3.
doi: 10.1016/j.ijgo.2004.09.004
Japan Society of Obstetrics and Gynecology, and Japan Association of Obstetricians and Gynecologists. [Guideline for gynecological practice in Japan, 2017]. https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902266877023542 . Accessed Nov 17, 2021. (In Japanese).
Ministry of Health, Labour and Welfare. [Health Sciences Research: Children’s Household Comprehensive Research Project; a questionnaire survey of 10,000 general women]. https://research-er.jp/projects/view/129384 . Accessed Sep 4, 2021. (In Japanese).
Unsal A, Ayranci U, Tozun M, Arslan G, Calik E. Prevalence of dysmenorrhea and its effect on quality of life among a group of female university students. Ups J Med Sci. 2010;115:138–45.
doi: 10.3109/03009730903457218
Wong CL. Health-related quality of life among Chinese adolescent girls with dysmenorrhoea. Reprod Health. 2018;15:80.
doi: 10.1186/s12978-018-0540-5
Tabuchi Y, Yoshidome A, Ban N, Kumagai Y, Kusama T. A survey of the relationship between HRQoL and menstrual symptoms in Japanese patients with endometriosis. Health Care. 2016;58:567–72 (In Japanese).
Eryilmaz G, Ozdemir F, Pasinlioglu T. Dysmenorrhea prevalence among adolescents in eastern Turkey: its effects on school performance and relationships with family and friends. J Pediatr Adolesc Gynecol. 2010;23:267–72.
doi: 10.1016/j.jpag.2010.02.009
Wong LP, Khoo EM. Dysmenorrhea in a multiethnic population of adolescent Asian girls. Int J Gynaecol Obstet. 2010;108:139–42.
doi: 10.1016/j.ijgo.2009.09.018
Ortiz MI, Rangel-Flores E, Carrillo-Alarcon LC, Veras-Godoy HA. Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009;107:240–3.
doi: 10.1016/j.ijgo.2009.07.031
Kawaguchi R, Matsumoto K, Akira S, et al. Guidelines for office gynecology in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2017 edition. J Obstet Gynaecol Res. 2019;45:766–86.
doi: 10.1111/jog.13831
Momoeda M, Akiyama S, Tanaka K, Suzukamo Y. Quality of life in Japanese patients with dysmenorrhea treated with ethinylestradiol 20 μg/drospirenone 3 mg in a real-world setting: an observational study. Int J Womens Health. 2020;12:327–38.
doi: 10.2147/IJWH.S238460
Kumano S. GPSP: good post-marketing study practice. Nihon Yakurigaku Zasshi. 2012;140(2):81–4 (In Japanese).
doi: 10.1254/fpj.140.81
Moos RH. The development of a menstrual distress questionnaire. Psychosom Med. 1968;30:853–67.
doi: 10.1097/00006842-196811000-00006
Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993;4:353–65.
doi: 10.2165/00019053-199304050-00006
Yamamoto S, Ishimori S, Sunaya T, Watanabe A, Sato S. The evaluation of safety and efficacy of drospirenone- and ethinylestradiol-containing tablet in patients with pain associated with endometriosis and patients with dysmenorrhea—report of interim analysis of use-result survey. Therapeutic Res. 2020;41:381–96.
Norman GR, Sloan JA, Wyrwich KW. Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation. Med Care. 2003;4:582–92.
King MT. A point of minimal important difference (MID): a critique of terminology and methods. Expert Rev Pharmacoecon Outcomes Res. 2011;11:171–84.
doi: 10.1586/erp.11.9
Tsuno Y. Health and productivity of medical professionals in medical institutions: from the viewpoint of health management. Soc Secur Res. 2019;3:492–504 (In Japanese).
The Japan Society of Obstetrics and Gynecology/The Japan Society for Menopause and Women’s Health. [Guidelines concerning the use of OC/low-dose estrogen–progestin 2020]. 2021. https://www.jsog.or.jp/modules/journal/index.php?content_id=2 . Accessed Sep 4, 2021. (In Japanese).
Momoeda M, Akiyama S, Yamamoto S, Kondo M, Fukai T. Burden of menstrual pain measured by heatmap visualization of daily patient-reported data in Japanese patients treated with ethinylestradiol/drospirenone: a randomized controlled study. Int J Womens Health. 2020;12:175–85.
doi: 10.2147/IJWH.S242864