Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer's Disease.
Biomarker
Cognitive tests
Gender
Inflammation
Resolution
Subjective cognitive impairment
Tau
β-amyloid
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
11
01
2022
accepted:
17
03
2022
pubmed:
2
4
2022
medline:
3
3
2023
entrez:
1
4
2022
Statut:
ppublish
Résumé
Alzheimer's disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in the pathogenesis of AD and is associated with cognitive impairment. Specialized pro-resolving lipid mediators (LMs) that promote the resolution of inflammation may be valuable markers in AD diagnosis and as therapeutic targets. Liquid chromatography-tandem mass spectrometry was used to analyze pro-resolving and pro-inflammatory LMs in cerebrospinal fluid (CSF) from patients with cognitive impairment ranging from subjective impairment to a diagnosis of AD and correlated to cognition, CSF tau, and β-amyloid. Resolvin (Rv) D4, RvD1, neuroprotectin D1 (NPD1), maresin 1 (MaR1), and RvE4 were lower in AD and/or MCI compared to SCI. The pro-inflammatory LTB
Identifiants
pubmed: 35362880
doi: 10.1007/s10571-022-01216-5
pii: 10.1007/s10571-022-01216-5
pmc: PMC9957874
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
tau Proteins
0
Peptide Fragments
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
797-811Subventions
Organisme : Vardalinstitutet
ID : 2018-02601
Organisme : Stockholms Läns Landsting
ID : SLL20180425
Organisme : Stockholms Läns Landsting
ID : RS 2019-1054
Informations de copyright
© 2022. The Author(s).
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