Theranostic Trigger-Responsive Carbon Monoxide-Generating Microbubbles.
carbon monoxide therapy
cardiovascular disease
microbubbles
poly-n-butyl-cyanoacrylate (PBCA)
ultrasound
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
04
03
2022
received:
11
02
2022
pubmed:
2
4
2022
medline:
7
5
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
Carbon monoxide (CO) is a gaseous signaling molecule that modulates inflammation, cell survival, and recovery after myocardial infarction. However, handling and dosing of CO as a compressed gas are difficult. Here, light-triggerable and magnetic resonance imaging (MRI)-detectable CO release from dimanganese decacarbonyl (CORM-1) are demonstrated, and the development of CORM-1-loaded polymeric microbubbles (COMB) is described as an ultrasound (US)- and MRI-imageable drug delivery platform for triggerable and targeted CO therapy. COMB are synthesized via a straightforward one-step loading protocol, present a narrow size distribution peaking at 2 µm, and show excellent performance as a CORM-1 carrier and US contrast agent. Light irradiation of COMB induces local production and release of CO, as well as enhanced longitudinal and transversal relaxation rates, enabling MRI monitoring of CO delivery. Proof-of-concept studies for COMB-enabled light-triggered CO release show saturation of hemoglobin with CO in human blood, anti-inflammatory differentiation of macrophages, reduction of hypoxia-induced reactive oxygen species (ROS) production, and inhibition of ischemia-induced apoptosis in endothelial cells and cardiomyocytes. These findings indicate that CO-generating MB are interesting theranostic tools for attenuating hypoxia-associated and ROS-mediated cell and tissue damage in cardiovascular disease.
Identifiants
pubmed: 35363403
doi: 10.1002/smll.202200924
doi:
Substances chimiques
Organometallic Compounds
0
Reactive Oxygen Species
0
Carbon Monoxide
7U1EE4V452
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2200924Subventions
Organisme : European Research Council
ID : 864 121
Pays : International
Informations de copyright
© 2022 The Authors. Small published by Wiley-VCH GmbH.
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