Does exercise influence burn-induced inflammation: A cross-over randomised controlled feasibility trial.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
10
2021
accepted:
06
03
2022
entrez:
1
4
2022
pubmed:
2
4
2022
medline:
15
4
2022
Statut:
epublish
Résumé
Burn injuries trigger a greater and more persistent inflammatory response than other trauma cases. Exercise has been shown to positively influence inflammation in healthy and diseased populations, however little is known about the latent effect of exercise on chronic inflammation in burn injured patients. The aims of the pilot study were to assess the feasibility of implementing a long duration exercise training program, in burn injured individuals including learnings associated with conducting a clinical trial in COVID-19 pandemic. Fifteen participants with a burn injury between 5-20% total body surface area acquired greater than a year ago were randomised in a within-subject designed study, into one of two conditions, exercise-control or control-exercise. The exercise condition consisted of six weeks of resistance and cardiovascular exercises, completed remotely or supervised in a hospital gym. A comprehensive outcome measurement was completed at the initial, mid and end point of each exercise and control condition. To determine the success of implementation, the feasibility indicator for the data completeness across the comprehensive outcome battery was set at 80%. Half (49%) of eligible participants in the timeframe, were recruited and commenced the study. Six participants withdrew prior to completion and a total of 15 participants completed the study. Eight participants were randomised to the exercise-control and seven to the control exercise group. Five participants trained remotely and seven did supervised training. Three participants completed a mix of both supervised and remote training initiated due to COVID restrictions. Outcome measures were completed on 97% of protocolised occasions and 100% of participants completed the exercise training. Conducting a long duration exercise training study on burn injured individuals is feasible using the described methods. The knowledge gained helps improve the methodology in larger-scale projects. Insights into the impact of COVID-19 on this clinical trial and success enhancing adaptations for the researcher, research practice and the participant, are presented.
Sections du résumé
BACKGROUND
Burn injuries trigger a greater and more persistent inflammatory response than other trauma cases. Exercise has been shown to positively influence inflammation in healthy and diseased populations, however little is known about the latent effect of exercise on chronic inflammation in burn injured patients. The aims of the pilot study were to assess the feasibility of implementing a long duration exercise training program, in burn injured individuals including learnings associated with conducting a clinical trial in COVID-19 pandemic.
METHODS
Fifteen participants with a burn injury between 5-20% total body surface area acquired greater than a year ago were randomised in a within-subject designed study, into one of two conditions, exercise-control or control-exercise. The exercise condition consisted of six weeks of resistance and cardiovascular exercises, completed remotely or supervised in a hospital gym. A comprehensive outcome measurement was completed at the initial, mid and end point of each exercise and control condition. To determine the success of implementation, the feasibility indicator for the data completeness across the comprehensive outcome battery was set at 80%.
RESULTS
Half (49%) of eligible participants in the timeframe, were recruited and commenced the study. Six participants withdrew prior to completion and a total of 15 participants completed the study. Eight participants were randomised to the exercise-control and seven to the control exercise group. Five participants trained remotely and seven did supervised training. Three participants completed a mix of both supervised and remote training initiated due to COVID restrictions. Outcome measures were completed on 97% of protocolised occasions and 100% of participants completed the exercise training.
CONCLUSIONS
Conducting a long duration exercise training study on burn injured individuals is feasible using the described methods. The knowledge gained helps improve the methodology in larger-scale projects. Insights into the impact of COVID-19 on this clinical trial and success enhancing adaptations for the researcher, research practice and the participant, are presented.
Identifiants
pubmed: 35363821
doi: 10.1371/journal.pone.0266400
pii: PONE-D-21-34321
pmc: PMC8974991
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0266400Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Burns. 2010 Nov;36(7):1013-20
pubmed: 20395052
Trials. 2020 Sep 11;21(1):784
pubmed: 32917258
Indian J Plast Surg. 2012 May;45(2):364-73
pubmed: 23162236
BMJ Open. 2014 Jan 17;4(1):e003845
pubmed: 24441050
Int J Med Inform. 2020 Feb;134:104039
pubmed: 31865054
Burns. 2012 May;38(3):340-7
pubmed: 22137442
Burns. 2016 Nov;42(7):1548-1555
pubmed: 27143342
Prog Mol Biol Transl Sci. 2015;135:337-54
pubmed: 26477921
Physiol Rev. 2000 Jul;80(3):1055-81
pubmed: 10893431
Epidemiology. 2002 Sep;13(5):561-8
pubmed: 12192226
Burns Trauma. 2019 Sep 16;7:23
pubmed: 31534977
Exerc Immunol Rev. 2006;12:6-33
pubmed: 17201070
Eur J Appl Physiol Occup Physiol. 1987;56(6):679-85
pubmed: 3678222
Int J Behav Nutr Phys Act. 2016 Dec 7;13(1):127
pubmed: 27927218
Burns. 2016 Sep;42(6):1233-40
pubmed: 27126812
Curr Opin Hematol. 2001 May;8(3):137-41
pubmed: 11303145
Burns. 2021 Feb;47(1):84-100
pubmed: 33280953
Burns. 2020 Sep;46(6):1424-1431
pubmed: 32593481
J Immunol. 1985 Aug;135(2 Suppl):750s-754s
pubmed: 4008933
Burns. 2007 Nov;33(7):843-9
pubmed: 17686586
Phys Ther. 2020 Aug 12;100(8):1411-1418
pubmed: 32383770
J Burn Care Res. 2016 Nov/Dec;37(6):388-396
pubmed: 27606549
J Burn Care Res. 2011 May-Jun;32(3):379-86
pubmed: 21448072
J Burn Care Res. 2017 Nov/Dec;38(6):e952-e959
pubmed: 28328660
BMC Public Health. 2020 Jan 29;20(1):121
pubmed: 31996206