Deciphering albumin-directed drug delivery by imaging.
Blood-brain barrier (BBB)
Human serum albumin (HSA)
Intravital microscopy
Magnetic resonance imaging (MRI)
Nanoparticulate albumin bound paclitaxel (nab-paclitaxel)
Positron emission tomography (PET)
Secreted protein acidic and rich in cysteine (SPARC)
Single-photon emission computed tomography (SPECT)
Journal
Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
received:
13
01
2022
revised:
10
03
2022
accepted:
23
03
2022
pubmed:
2
4
2022
medline:
20
5
2022
entrez:
1
4
2022
Statut:
ppublish
Résumé
Albumin is the most abundant plasma protein, exhibits extended circulating half-life, and its properties have long been exploited for diagnostics and therapies. Many drugs intrinsically bind albumin or have been designed to do so, yet questions remain about true rate limiting factors that govern albumin-based transport and their pharmacological impacts, particularly in advanced solid cancers. Imaging techniques have been central to quantifying - at a molecular and single-cell level - the impact of mechanisms such as phagocytic immune cell signaling, FcRn-mediated recycling, oncogene-driven macropinocytosis, and albumin-drug interactions on spatial albumin deposition and related pharmacology. Macroscopic imaging of albumin-binding probes quantifies vessel structure, permeability, and supports efficiently targeted molecular imaging. Albumin-based imaging in patients and animal disease models thus offers a strategy to understand mechanisms, guide drug development and personalize treatments.
Identifiants
pubmed: 35364124
pii: S0169-409X(22)00127-2
doi: 10.1016/j.addr.2022.114237
pmc: PMC9117484
mid: NIHMS1797214
pii:
doi:
Substances chimiques
Albumins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114237Subventions
Organisme : NCI NIH HHS
ID : DP2 CA259675
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA207744
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA079443
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest RW is a co-founder of T2Biosystems and Lumicell, serves as a scientific advisor for ModeRNA Therapeutics, Tarveda Therapeutics, Accure Health and Aikili Biosystems. MAM serves as a scientific advisor for January Therapeutics and has received past research support from Pfizer and Genentech/Roche. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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