Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

Abdullaev A, Odilov A, Ershler M, Volkov A, Lipina T, Gasanova T et al (2021) Viral load and patterns of SARS-CoV-2 dissemination to the lungs, mediastinal lymph nodes, and spleen of patients with COVID-19 associated lymphopenia. Viruses 13(7):1410. https://doi.org/10.3390/v13071410

Ackermann M, Gaumann A, Mentzer SJ, Hinrichs JB, Warnecke G, Hoeper MM, Braubach P, Kuehnel M, Maegel L, Jonigk D (2017) Plexiform vasculopathy in chronic thromboembolic pulmonary hypertension. Am J Respir Crit Care Med 196:e48–e51. https://doi.org/10.1164/rccm.201703-0591IM

doi: 10.1164/rccm.201703-0591IM pubmed: 28892403

Ackermann M, Houdek JP, Gibney BC, Ysasi A, Wagner W, Belle J, Schittny JC, Enzmann F, Tsuda A, Mentzer SJ, Konerding MA (2014) Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization. Angiogenesis 17:541–551. https://doi.org/10.1007/s10456-013-9399-9

doi: 10.1007/s10456-013-9399-9 pubmed: 24150281

Ackermann M, Mentzer SJ, Jonigk D (2020) Pulmonary vascular pathology in Covid-19. Reply N Engl J Med 383:888–889. https://doi.org/10.1056/NEJMc2022068

doi: 10.1056/NEJMc2022068 pubmed: 32678534

Ackermann M, Morse BA, Delventhal V, Carvajal IM, Konerding MA (2012) Anti-VEGFR2 and anti-IGF-1R-Adnectins inhibit Ewing’s sarcoma A673-xenograft growth and normalize tumor vascular architecture. Angiogenesis 15:685–695. https://doi.org/10.1007/s10456-012-9294-9

doi: 10.1007/s10456-012-9294-9 pubmed: 22914877

Ackermann M, Stark H, Neubert L, Schubert S, Borchert P, Linz F, Wagner WL, Stiller W, Wielputz M, Hoefer A, Haverich A, Mentzer SJ, Shah HR, Welte T, Kuehnel M, Jonigk D (2020) Morphomolecular motifs of pulmonary neoangiogenesis in interstitial lung diseases Eur Respir J 55. https://doi.org/10.1183/13993003.00933-2019

Ackermann M, Tsuda A, Secomb TW, Mentzer SJ, Konerding MA (2013) Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis. Microvasc Res 87:75–82. https://doi.org/10.1016/j.mvr.2013.02.002

doi: 10.1016/j.mvr.2013.02.002 pubmed: 23485588 pmcid: 3627825

Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D (2020) Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19 N Engl J Med 383:120-128. https://doi.org/10.1056/NEJMoa2015432

Ackermann M, Wagner WL, Rellecke P, Akhyari P, Boeken U, Reinecke P (2020) Parvovirus B19-induced angiogenesis in fulminant myocarditis. Eur Heart J 41:1309. https://doi.org/10.1093/eurheartj/ehaa092

doi: 10.1093/eurheartj/ehaa092 pubmed: 32101607

Alanio A, Delliere S, Fodil S, Bretagne S, Megarbane B (2020) Prevalence of putative invasive pulmonary aspergillosis in critically ill patients with COVID-19. Lancet Respir Med 8:e48–e49. https://doi.org/10.1016/S2213-2600(20)30237-X

doi: 10.1016/S2213-2600(20)30237-X pubmed: 32445626

Albert CL, Carmona-Rubio AE, Weiss AJ, Procop GG, Starling RC, Rodriguez ER (2020) The enemy within: sudden-onset reversible cardiogenic shock with biopsy-proven cardiac myocyte infection by severe acute respiratory syndrome Coronavirus 2. Circulation 142(19):1865–1870. https://doi.org/10.1161/CIRCULATIONAHA.120.050097

doi: 10.1161/CIRCULATIONAHA.120.050097 pubmed: 32997947

Aschman T, Schneider J, Greuel S, Meinhardt J, Streit S, Goebel HH, Buttnerova I, Elezkurtaj S, Scheibe F, Radke J, Meisel C, Drosten C, Radbruch H, Heppner FL, Corman VM, Stenzel W (2021) Association between SARS-CoV-2 infection and immune-mediated myopathy in patients who have died. JAMA Neurol 78:948–960. https://doi.org/10.1001/jamaneurol.2021.2004

doi: 10.1001/jamaneurol.2021.2004 pubmed: 34115106

Bacon ER, Ihle K, Lee PP, Waisman JR (2020) Building a rapid autopsy program—a step-by-step logistics guide. Translational Medicine Communications 5. https://doi.org/10.1186/s41231-020-00074-x

Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS, Fan E, Bartlett RH, Tonna JE, Hyslop R, Fanning JJ, Rycus PT, Hyer SJ, Anders MM, Agerstrand CL, Hryniewicz K, Diaz R, Lorusso R, Combes A, Brodie D, Extracorporeal Life Support O (2020) Extracorporeal membrane oxygenation support in COVID-19: an international cohort study of the Extracorporeal Life Support Organization registry. Lancet 396:1071–1078. https://doi.org/10.1016/S0140-6736(20)32008-0

doi: 10.1016/S0140-6736(20)32008-0 pubmed: 32987008 pmcid: 7518880

Barton LM, Duval EJ, Stroberg E, Ghosh S, Mukhopadhyay S (2020) COVID-19 Autopsies, Oklahoma, USA. Am J Clin Pathol 153:725–733. https://doi.org/10.1093/ajcp/aqaa062

doi: 10.1093/ajcp/aqaa062 pubmed: 32275742

Bernard I, Limonta D, Mahal LK, Hobman TC (2020) Endothelium infection and dysregulation by SARS-CoV-2: evidence and caveats in COVID-19. Viruses 13(1):29. https://doi.org/10.3390/v13010029

Bosmuller H, Matter M, Fend F, Tzankov A (2021) The pulmonary pathology of COVID-19. Virchows Arch 478:137–150. https://doi.org/10.1007/s00428-021-03053-1

doi: 10.1007/s00428-021-03053-1 pubmed: 33604758 pmcid: 7892326

Bosmuller H, Traxler S, Bitzer M, Haberle H, Raiser W, Nann D, Frauenfeld L, Vogelsberg A, Klingel K, Fend F (2020) The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation. Virchows Arch 477:349–357. https://doi.org/10.1007/s00428-020-02881-x

doi: 10.1007/s00428-020-02881-x pubmed: 32607684 pmcid: 7324489

Bradley BT, Maioli H, Johnston R, Chaudhry I, Fink SL, Xu H, Najafian B, Deutsch G, Lacy JM, Williams T, Yarid N, Marshall DA (2020) Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. Lancet 396:320–332. https://doi.org/10.1016/S0140-6736(20)31305-2

doi: 10.1016/S0140-6736(20)31305-2 pubmed: 32682491 pmcid: 7365650

Braun F, Lutgehetmann M, Pfefferle S, Wong MN, Carsten A, Lindenmeyer MT, Norz D, Heinrich F, Meissner K, Wichmann D, Kluge S, Gross O, Pueschel K, Schroder AS, Edler C, Aepfelbacher M, Puelles VG, Huber TB (2020) SARS-CoV-2 renal tropism associates with acute kidney injury. Lancet 396:597–598. https://doi.org/10.1016/S0140-6736(20)31759-1

doi: 10.1016/S0140-6736(20)31759-1 pubmed: 32818439 pmcid: 7431179

Braun J, Loyal L, Frentsch M, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Rohmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Muller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A (2020) SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature 587:270–274. https://doi.org/10.1038/s41586-020-2598-9

doi: 10.1038/s41586-020-2598-9 pubmed: 32726801

Brighenti A, Andrulis M, Geissinger E, Roth S, Muller-Hermelink HK, Rudiger T (2005) Extrafollicular proliferation of B cells in the absence of follicular hyperplasia: a distinct reaction pattern in lymph nodes correlated with primary or recall type responses. Histopathology 47:90–100. https://doi.org/10.1111/j.1365-2559.2005.02173.x

doi: 10.1111/j.1365-2559.2005.02173.x pubmed: 15982328

Budinger GRS, Misharin AV, Ridge KM, Singer BD, Wunderink RG (2021) Distinctive features of severe SARS-CoV-2 pneumonia J Clin Invest 131. https://doi.org/10.1172/JCI149412

Buja LM, Stone JR (2021) A novel coronavirus meets the cardiovascular system: Society for Cardiovascular Pathology Symposium 2021. Cardiovasc Pathol 53:107336. https://doi.org/10.1016/j.carpath.2021.107336

doi: 10.1016/j.carpath.2021.107336 pubmed: 33895311 pmcid: 8062417

Bulfamante G, Bocci T, Falleni M, Campiglio L, Coppola S, Tosi D, Chiumello D, Priori A (2021) Brainstem neuropathology in two cases of COVID-19: SARS-CoV-2 trafficking between brain and lung. J Neurol 268:4486–4491. https://doi.org/10.1007/s00415-021-10604-8

doi: 10.1007/s00415-021-10604-8 pubmed: 34003372 pmcid: 8129960

Chappell CP, Draves KE, Giltiay NV, Clark EA (2012) Extrafollicular B cell activation by marginal zone dendritic cells drives T cell-dependent antibody responses. J Exp Med 209:1825–1840. https://doi.org/10.1084/jem.20120774

doi: 10.1084/jem.20120774 pubmed: 22966002 pmcid: 3457737

Chen C, Zhou Y, Wang DW (2020) SARS-CoV-2: a potential novel etiology of fulminant myocarditis. Herz 45:230–232. https://doi.org/10.1007/s00059-020-04909-z

doi: 10.1007/s00059-020-04909-z pubmed: 32140732 pmcid: 7080076

Chen W, Tian Y, Li Z, Zhu J, Wei T, Lei J (2021) Potential interaction between SARS-CoV-2 and thyroid: a review Endocrinology 162 https://doi.org/10.1210/endocr/bqab004

Chou SH, Beghi E, Helbok R, Moro E, Sampson J, Altamirano V, Mainali S, Bassetti C, Suarez JI, McNett M, Consortium GC-N, Consortium E (2021) Global incidence of neurological manifestations among patients hospitalized with COVID-19-A report for the GCS-NeuroCOVID consortium and the ENERGY Consortium. JAMA Netw Open 4:e2112131 https://doi.org/10.1001/jamanetworkopen.2021.12131

Clark A, Jit M, Warren-Gash C, Guthrie B, Wang HHX, Mercer SW, Sanderson C, McKee M, Troeger C, Ong KL, Checchi F, Perel P, Joseph S, Gibbs HP, Banerjee A, Eggo RM, COVI CMMID, (2020) Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study. Lancet Glob Health 8:1003–1017. https://doi.org/10.1016/S2214-109x(20)30264-3

doi: 10.1016/S2214-109x(20)30264-3

Davies P, Evans C, Kanthimathinathan HK, Lillie J, Brierley J, Waters G, Johnson M, Griffiths B, du Pre P, Mohammad Z, Deep A, Playfor S, Singh D, Inwald D, Jardine M, Ross O, Shetty N, Worrall M, Sinha R, Koul A, Whittaker E, Vyas H, Scholefield BR, Ramnarayan P (2020) Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multicentre observational study. Lancet Child Adolesc Health 4:669–677. https://doi.org/10.1016/S2352-4642(20)30215-7

doi: 10.1016/S2352-4642(20)30215-7 pubmed: 32653054 pmcid: 7347350

de Madaria E, Capurso G (2021) COVID-19 and acute pancreatitis: examining the causality. Nat Rev Gastroenterol Hepatol 18:3–4. https://doi.org/10.1038/s41575-020-00389-y

doi: 10.1038/s41575-020-00389-y

De Biasi S, Lo Tartaro D, Meschiari M, Gibellini L, Bellinazzi C, Borella R, Fidanza L, Mattioli M, Paolini A, Gozzi L, Jaacoub D, Faltoni M, Volpi S, Milic J, Sita M, Sarti M, Pucillo C, Girardis M, Guaraldi G, Mussini C, Cossarizza A (2020) Expansion of plasmablasts and loss of memory B cells in peripheral blood from COVID-19 patients with pneumonia. Eur J Immunol 50:1283–1294. https://doi.org/10.1002/eji.202048838

doi: 10.1002/eji.202048838 pubmed: 32910469

Deigendesch N, Sironi L, Kutza M, Wischnewski S, Fuchs V, Hench J, Frank A, Nienhold R, Mertz KD, Cathomas G, Matter MS, Siegemund M, Tolnay M, Schirmer L, Probstel AK, Tzankov A, Frank S (2020) Correlates of critical illness-related encephalopathy predominate postmortem COVID-19 neuropathology. Acta Neuropathol 140:583–586. https://doi.org/10.1007/s00401-020-02213-y

doi: 10.1007/s00401-020-02213-y pubmed: 32851506 pmcid: 7449525

Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juarez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe’er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A (2021) COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature 595:107–113. https://doi.org/10.1038/s41586-021-03570-8

doi: 10.1038/s41586-021-03570-8 pubmed: 33915569 pmcid: 8919505

Deng Q, Hu B, Zhang Y, Wang H, Zhou X, Hu W, Cheng Y, Yan J, Ping H, Zhou Q (2020) Suspected myocardial injury in patients with COVID-19: evidence from front-line clinical observation in Wuhan, China. Int J Cardiol 311:116–121. https://doi.org/10.1016/j.ijcard.2020.03.087

doi: 10.1016/j.ijcard.2020.03.087 pubmed: 32291207 pmcid: 7141178

Dettmeyer R, Lasczkowski G, Weber A, Wolter T, Kernbach-Wighton G (2020) [Histopathological findings following SARS-CoV-2 infection with and without treatment-Report of three autopsies] Rechtsmedizin (Berl):1–8 https://doi.org/10.1007/s00194-020-00408-x

Dewaele K, Claeys R (2020) Hemophagocytic lymphohistiocytosis in SARS-CoV-2 infection. Blood 135:2323. https://doi.org/10.1182/blood.2020006505

doi: 10.1182/blood.2020006505 pubmed: 32556137

Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG, investigators IC, (2020) Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 369:m1985. https://doi.org/10.1136/bmj.m1985

doi: 10.1136/bmj.m1985 pubmed: 32444460 pmcid: 7243036

Duarte-Neto AN, Monteiro RAA, da Silva LFF, Malheiros D, de Oliveira EP, Theodoro-Filho J, Pinho JRR, Gomes-Gouvea MS, Salles APM, de Oliveira IRS, Mauad T, Saldiva PHN, Dolhnikoff M (2020) Pulmonary and systemic involvement in COVID-19 patients assessed with ultrasound-guided minimally invasive autopsy. Histopathology 77:186–197. https://doi.org/10.1111/his.14160

doi: 10.1111/his.14160 pubmed: 32443177 pmcid: 7280721

Ebina M, Shimizukawa M, Shibata N, Kimura Y, Suzuki T, Endo M, Sasano H, Kondo T, Nukiwa T (2004) Heterogeneous increase in CD34-positive alveolar capillaries in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 169:1203–1208. https://doi.org/10.1164/rccm.200308-1111OC

doi: 10.1164/rccm.200308-1111OC pubmed: 14754760

Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, Tzankov A, Werlein C, Kuhnel M, Jonigk D, Salditt T (2020) 3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography Elife 9. https://doi.org/10.7554/eLife.60408

Edler C, Schroder AS, Aepfelbacher M, Fitzek A, Heinemann A, Heinrich F, Klein A, Langenwalder F, Lutgehetmann M, Meissner K, Puschel K, Schadler J, Steurer S, Mushumba H, Sperhake JP (2020) Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany. Int J Legal Med 134:1275–1284. https://doi.org/10.1007/s00414-020-02317-w

doi: 10.1007/s00414-020-02317-w pubmed: 32500199 pmcid: 7271136

Evert K, Dienemann T, Brochhausen C, Lunz D, Lubnow M, Ritzka M, Keil F, Trummer M, Scheiter A, Salzberger B, Reischl U, Boor P, Gessner A, Jantsch J, Calvisi DF, Evert M, Schmidt B, Simon M (2021) Autopsy findings after long-term treatment of COVID-19 patients with microbiological correlation. Virchows Arch 479:97–108. https://doi.org/10.1007/s00428-020-03014-0

doi: 10.1007/s00428-020-03014-0 pubmed: 33471172 pmcid: 7816067

Faruqui S, Okoli FC, Olsen SK, Feldman DM, Kalia HS, Park JS, Stanca CM, Figueroa Diaz V, Yuan S, Dagher NN, Sarkar SA, Theise ND, Kim S, Shanbhogue K, Jacobson IM (2021) Cholangiopathy after severe COVID-19: clinical features and prognostic implications. Am J Gastroenterol 116:1414–1425. https://doi.org/10.14309/ajg.0000000000001264

doi: 10.14309/ajg.0000000000001264 pubmed: 33993134

Fassan M, Mescoli C, Sbaraglia M, Guzzardo V, Russo FP, Fabris R, Trevenzoli M, Pelizzaro F, Cattelan AM, Basso C, Navalesi P, Farinati F, Vettor R, Dei Tos AP (2021) Liver histopathology in COVID-19 patients: a mono-Institutional series of liver biopsies and autopsy specimens. Pathol Res Pract 221:153451. https://doi.org/10.1016/j.prp.2021.153451

doi: 10.1016/j.prp.2021.153451 pubmed: 33932720 pmcid: 8054534

Feld J, Tremblay D, Thibaud S, Kessler A, Naymagon L (2020) Ferritin levels in patients with COVID-19: A poor predictor of mortality and hemophagocytic lymphohistiocytosis. Int J Lab Hematol 42:773–779. https://doi.org/10.1111/ijlh.13309

doi: 10.1111/ijlh.13309 pubmed: 32790918 pmcid: 7436675

Ferlicot S, Jamme M, Gaillard F, Oniszczuk J, Couturier A, May O, Grunenwald A, Sannier A, Moktefi A, Le Monnier O, Petit-Hoang C, Maroun N, Brodin-Sartorius A, Michon A, Dobosziewicz H, Andreelli F, Guillet M, Izzedine H, Richard C, Dekeyser M, Arrestier R, Sthele T, Lefevre E, Mathian A, Legendre C, Mussini C, Verpont MC, Pallet N, Amoura Z, Essig M, Snanoudj R, Brocheriou-Spelle I, Francois H, Belenfant X, Geri G, Daugas E, Audard V, Buob D, Massy ZA, Zaidan M, collaboration AP-HUIC-r (2021) The spectrum of kidney biopsies in hospitalized patients with COVID-19, acute kidney injury, and/or proteinuria. Nephrol Dial Transplant https://doi.org/10.1093/ndt/gfab042

Fox SE, Lameira FS, Rinker EB, Vander Heide RS (2020) Cardiac endotheliitis and multisystem inflammatory syndrome after COVID-19. Ann Intern Med 173:1025–1027. https://doi.org/10.7326/L20-0882

doi: 10.7326/L20-0882 pubmed: 32726150

Fox SE, Li G, Akmatbekov A, Harbert JL, Lameira FS, Brown JQ, Vander Heide RS (2020) Unexpected features of cardiac pathology in COVID-19 infection circulation 142:1123–1125 https://doi.org/10.1161/CIRCULATIONAHA.120.049465

Gauchotte G, Venard V, Segondy M, Cadoz C, Esposito-Fava A, Barraud D, Louis G (2021) SARS-Cov-2 fulminant myocarditis: an autopsy and histopathological case study. Int J Legal Med 135:577–581. https://doi.org/10.1007/s00414-020-02500-z

doi: 10.1007/s00414-020-02500-z pubmed: 33392658 pmcid: 7779100

Glatzel M, Hagel C, Matschke J, Sperhake J, Deigendesch N, Tzankov A, Frank S (2021) Neuropathology associated with SARS-CoV-2 infection. Lancet 397:276. https://doi.org/10.1016/S0140-6736(21)00098-2

doi: 10.1016/S0140-6736(21)00098-2 pubmed: 33485445 pmcid: 7826128

Grimaud M, Starck J, Levy M, Marais C, Chareyre J, Khraiche D, Leruez-Ville M, Quartier P, Leger PL, Geslain G, Semaan N, Moulin F, Bendavid M, Jean S, Poncelet G, Renolleau S, Oualha M (2020) Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children. Ann Intensive Care 10:69. https://doi.org/10.1186/s13613-020-00690-8

doi: 10.1186/s13613-020-00690-8 pubmed: 32488505 pmcid: 7266128

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, Liu L, Shan H, Lei CL, Hui DSC, Du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS, China Medical Treatment Expert Group for C (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382:1708–1720 https://doi.org/10.1056/NEJMoa2002032

Guidon AC, Amato AA (2020) COVID-19 and neuromuscular disorders. Neurology 94:959–969. https://doi.org/10.1212/WNL.0000000000009566

doi: 10.1212/WNL.0000000000009566 pubmed: 32284362

Guo M, Tao W, Flavell RA, Zhu S (2021) Potential intestinal infection and faecal-oral transmission of SARS-CoV-2. Nat Rev Gastroenterol Hepatol 18:269–283. https://doi.org/10.1038/s41575-021-00416-6

doi: 10.1038/s41575-021-00416-6 pubmed: 33589829 pmcid: 7883337

Gupta A, Weitzman S, Abdelhaleem M (2008) The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 50:192–194. https://doi.org/10.1002/pbc.21441

doi: 10.1002/pbc.21441 pubmed: 18061932

Gustine JN, Jones D (2021) Immunopathology of hyperinflammation in COVID-19. Am J Pathol 191:4–17. https://doi.org/10.1016/j.ajpath.2020.08.009

doi: 10.1016/j.ajpath.2020.08.009 pubmed: 32919977 pmcid: 7484812

Halushka MK, Vander Heide RS (2021) Myocarditis is rare in COVID-19 autopsies: cardiovascular findings across 277 postmortem examinations. Cardiovasc Pathol 50:107300. https://doi.org/10.1016/j.carpath.2020.107300

doi: 10.1016/j.carpath.2020.107300 pubmed: 33132119

Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 203:631–637. https://doi.org/10.1002/path.1570

doi: 10.1002/path.1570 pubmed: 15141377 pmcid: 7167720

Haslbauer JD, Matter MS, Stalder AK, Tzankov A (2021) Histomorphological patterns of regional lymph nodes in COVID-19 lungs. Pathologe https://doi.org/10.1007/s00292-021-00945-6

Haslbauer JD, Tzankov A, Mertz KD, Schwab N, Nienhold R, Twerenbold R, Leibundgut G, Stalder AK, Matter M, Glatz K (2021) Characterisation of cardiac pathology in 23 autopsies of lethal COVID-19. J Pathol Clin Res 7:326–337. https://doi.org/10.1002/cjp2.212

doi: 10.1002/cjp2.212 pubmed: 33837673 pmcid: 8185365

Haslbauer JD, Zinner C, Stalder AK, Schneeberger J, Menter T, Bassetti S, Mertz KD, Went P, Matter MS, Tzankov A (2021) Vascular damage, Thromboinflammation, Plasmablast activation, T-cell dysregulation and pathological histiocytic response in pulmonary draining lymph nodes of COVID-19. Front Immunol 12:763098. https://doi.org/10.3389/fimmu.2021.763098

doi: 10.3389/fimmu.2021.763098 pubmed: 34966385 pmcid: 8710573

Heinrich F, Meissner K, Langenwalder F, Puschel K, Norz D, Hoffmann A, Lutgehetmann M, Aepfelbacher M, Bibiza-Freiwald E, Pfefferle S, Heinemann A (2021) Postmortem stability of SARS-CoV-2 in nasopharyngeal mucosa Emerg Infect Dis 27. https://doi.org/10.3201/eid2701.203112

Henwood M, Lake D, Allen F, Sange M (2021) Myocarditis in SARS-CoV-2 negative patients with suspected preceding infection BMJ Case Rep 14 https://doi.org/10.1136/bcr-2020-239513

Hirschbuhl K, Schaller T, Kling E, Markl B, Claus R (2020) Autopsy of patients with COVID-19: a balance of fear and curiosity. Pathol Res Pract 216:153039. https://doi.org/10.1016/j.prp.2020.153039

doi: 10.1016/j.prp.2020.153039 pubmed: 32703502 pmcid: 7261439

Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181(2):271–280 e8. https://doi.org/10.1016/j.cell.2020.02.052

Hopfer H, Herzig MC, Gosert R, Menter T, Hench J, Tzankov A, Hirsch HH, Miller SE (2021) Hunting coronavirus by transmission electron microscopy—a guide to SARS-CoV-2-associated ultrastructural pathology in COVID-19 tissues. Histopathology 78:358–370. https://doi.org/10.1111/his.14264

doi: 10.1111/his.14264 pubmed: 32981112

Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH 3rd et al (2020) SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell 82(2):429–446 e14. https://doi.org/10.1016/j.cell.2020.05.042

Hu H, Ma F, Wei X, Fang Y (2021) Coronavirus fulminant myocarditis treated with glucocorticoid and human immunoglobulin. Eur Heart J 42:206. https://doi.org/10.1093/eurheartj/ehaa190

doi: 10.1093/eurheartj/ehaa190 pubmed: 32176300

Huertas A, Montani D, Savale L, Pichon J, Tu L, Parent F, Guignabert C, Humbert M (2020) Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)? Eur Respir J 56. https://doi.org/10.1183/13993003.01634-2020

Hughes S, Troise O, Donaldson H, Mughal N, Moore LSP (2020) Bacterial and fungal coinfection among hospitalized patients with COVID-19: a retrospective cohort study in a UK secondary-care setting. Clin Microbiol Infect 26:1395–1399. https://doi.org/10.1016/j.cmi.2020.06.025

doi: 10.1016/j.cmi.2020.06.025 pubmed: 32603803 pmcid: 7320692

Inciardi RM, Lupi L, Zaccone G, Italia L, Raffo M, Tomasoni D, Cani DS, Cerini M, Farina D, Gavazzi E, Maroldi R, Adamo M, Ammirati E, Sinagra G, Lombardi CM, Metra M (2020) Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19). JAMA Cardiol 5:819–824. https://doi.org/10.1001/jamacardio.2020.1096

doi: 10.1001/jamacardio.2020.1096 pubmed: 32219357

Jager KJ, Kramer A, Chesnaye NC, Couchoud C, Sanchez-Alvarez JE, Garneata L, Collart F, Hemmelder MH, Ambuhl P, Kerschbaum J, Legeai C, Del Pino YPMD, Mircescu G, Mazzoleni L, Hoekstra T, Winzeler R, Mayer G, Stel VS, Wanner C, Zoccali C, Massy ZA (2020) Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe. Kidney Int 98:1540–1548. https://doi.org/10.1016/j.kint.2020.09.006

doi: 10.1016/j.kint.2020.09.006 pubmed: 32979369 pmcid: 7560263

Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF, Jr., Pillai S, Massachusetts Consortium on Pathogen Readiness Specimen Working G (2020) Loss of Bcl-6-expressing T follicular helper cells and Germinal centers in COVID-19. Cell 183:143–157 e113 https://doi.org/10.1016/j.cell.2020.08.025

Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, Klauber J, Janssens U, Marx G, Weber-Carstens S, Kluge S, Pfeifer M, Grabenhenrich L, Welte T, Busse R (2020) Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Resp Med 8:853–862. https://doi.org/10.1016/S2213-2600(20)30316-7

doi: 10.1016/S2213-2600(20)30316-7

Katzenstein AL, Bloor CM, Leibow AA (1976) Diffuse alveolar damage—the role of oxygen, shock, and related factors. A review. Am J Pathol 85:209–228

pubmed: 788524 pmcid: 2032554

Kawakami R, Sakamoto A, Kawai K, Gianatti A, Pellegrini D, Nasr A, Kutys B, Guo L, Cornelissen A, Mori M, Sato Y, Pescetelli I, Brivio M, Romero M, Guagliumi G, Virmani R, Finn AV (2021) Pathological evidence for SARS-CoV-2 as a cause of myocarditis: JACC Review Topic of the Week. J Am Coll Cardiol 77:314–325. https://doi.org/10.1016/j.jacc.2020.11.031

doi: 10.1016/j.jacc.2020.11.031 pubmed: 33478655 pmcid: 7816957

Keddie S, Pakpoor J, Mousele C, Pipis M, Machado PM, Foster M, Record CJ, Keh RYS, Fehmi J, Paterson RW, Bharambe V, Clayton LM, Allen C, Price O, Wall J, Kiss-Csenki A, Rathnasabapathi DP, Geraldes R, Yermakova T, King-Robson J, Zosmer M, Rajakulendran S, Sumaria S, Farmer SF, Nortley R, Marshall CR, Newman EJ, Nirmalananthan N, Kumar G, Pinto AA, Holt J, Lavin TM, Brennan KM, Zandi MS, Jayaseelan DL, Pritchard J, Hadden RDM, Manji H, Willison HJ, Rinaldi S, Carr AS, Lunn MP (2021) Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barre syndrome. Brain 144:682–693. https://doi.org/10.1093/brain/awaa433

doi: 10.1093/brain/awaa433 pubmed: 33313649

Khan M, Yoo SJ, Clijsters M, Backaert W, Vanstapel A, Speleman K, Lietaer C, Choi S, Hether TD, Marcelis L, Nam A, Pan L, Reeves JW, Van Bulck P, Zhou H, Bourgeois M, Debaveye Y, De Munter P, Gunst J, Jorissen M, Lagrou K, Lorent N, Neyrinck A, Peetermans M, Thal DR, Vandenbriele C, Wauters J, Mombaerts P, Van Gerven L (2021) Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell 184(5932–5949):e5915. https://doi.org/10.1016/j.cell.2021.10.027

doi: 10.1016/j.cell.2021.10.027

Khoo B, Tan T, Clarke SA, Mills EG, Patel B, Modi M, Phylactou M, Eng PC, Thurston L, Alexander EC, Meeran K, Comninos AN, Abbara A, Dhillo WS (2021) Thyroid function before, during, and after COVID-19. J Clin Endocrinol Metab 106:e803–e811. https://doi.org/10.1210/clinem/dgaa830

doi: 10.1210/clinem/dgaa830 pubmed: 33180932

Kim IC, Kim JY, Kim HA, Han S (2020) COVID-19-related myocarditis in a 21-year-old female patient. Eur Heart J 41:1859. https://doi.org/10.1093/eurheartj/ehaa288

doi: 10.1093/eurheartj/ehaa288 pubmed: 32282027

Klein A, Edler C, Fitzek A, Frob D, Heinemann A, Meissner K, Mushumba H, Puschel K, Schroder AS, Sperhake JP, Ishorst-Witte F, Aepfelbacher M, Heinrich F (2020) [The first COVID-19 hotspot in a retirement home in Hamburg]. Rechtsmedizin (Berl):1–7 https://doi.org/10.1007/s00194-020-00404-1

Klindt C, Jensen BE, Brandenburger T, Feldt T, Killer A, Schimmoller L, Antoch G, Senff T, Hauka S, Timm J, Bahners BH, Seidl M, Esposito I, Luedde T, Bode JG, Keitel V (2021) Secondary sclerosing cholangitis as a complication of severe COVID-19: a case report and review of the literature. Clin Case Rep 9:e04068. https://doi.org/10.1002/ccr3.4068

doi: 10.1002/ccr3.4068 pubmed: 34084492 pmcid: 8142800

Klingenstein M, Klingenstein S, Neckel PH, Mack AF, Wagner AP, Kleger A et al (2020) Evidence of SARS-CoV2 entry protein ACE2 in the human nose and olfactory bulb. Cells Tissues Organs 209(4–6):155–164. https://doi.org/10.1159/000513040

Kniep I, Heinemann A, Edler C, Sperhake JP, Puschel K, Ondruschka B, Schroder AS (2021) COVID-19 lungs in post-mortem computed tomography. Rechtsmedizin (Berl):1–3 https://doi.org/10.1007/s00194-021-00462-z

Koehler P, Bassetti M, Chakrabarti A, Chen SCA, Colombo AL, Hoenigl M, Klimko N, Lass-Florl C, Oladele RO, Vinh DC, Zhu LP, Boll B, Bruggemann R, Gangneux JP, Perfect JR, Patterson TF, Persigehl T, Meis JF, Ostrosky-Zeichner L, White PL, Verweij PE, Cornely OA, European Confederation of Medical Mycology, International Society for Human Animal Mycology, Asia Fungal Working Group, INFOCUS LATAM/ISHAM Working Group, ISHAM Pan Africa Mycology Working Group, European Society for Clinical Microbiology, Infectious Diseases Fungal Infection Study Group, ESCMID Study Group for Infections in Critically Ill Patients, Interregional Association of Clinical Microbiology and Antimicrobial Chemotherapy, Medical Mycology Society of Nigeria, Medical Mycology Society of China Medicine Education Association, Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology, Association of Medical Microbiology, Infectious Disease Canada (2021) Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance. Lancet Infect Dis 21:e149–e162. https://doi.org/10.1016/S1473-3099(20)30847-1

Konopka KE, Wilson A (2019) Myers JL (2020) Postmortem lung findings in a patient with asthma and coronavirus disease. Chest 158:e99–e101. https://doi.org/10.1016/j.chest.2020.04.032

doi: 10.1016/j.chest.2020.04.032

Krasemann S, Dittmayer C, v. Stillfried S, Meinhardt J, Heinrich F, Hartmann K, Pfefferle S, Thies E, v. Manitius R, Aschman T, Radke J, Osterloh A, Schmid S, Buhl EM, Ihlow J, Elezkurtaj S, Horst D, Hocke AC, Timm S, Bachmann S, Corman V, Goebel HH, Matschke J, Stanelle-Bertram S, Gabriel G, Seilhean D, Adle-Biassette H, Ondruschka B, Ochs M, Stenzel W, Heppner FL, Boor P, Radbruch H, Laue M, Glatzel M (2022) Assessing and improving the validity of COVID-19 autopsy studies—a multicenter approach to establish essential standards for immunohistochemical and ultrastructural analyses. MedRxiv https://doi.org/10.1101/2022.01.13.22269205

Krasemann S, Haferkamp U, Pfefferle S, Woo MS, Heinrich F, Schweizer M, Appelt-Menzel A, Cubukova A, Barenberg J, Leu J, Hartmann K, Thies E, Littau JL, Sepulveda-Falla D, Zhang L, Ton K, Liang Y, Matschke J, Ricklefs F, Sauvigny T, Sperhake J, Fitzek A, Gerhartl A, Brachner A, Geiger N, Konig EM, Bodem J, Franzenburg S, Franke A, Moese S, Muller FJ, Geisslinger G, Claussen C, Kannt A, Zaliani A, Gribbon P, Ondruschka B, Neuhaus W, Friese MA, Glatzel M, Pless O (2022) The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2 Stem. Cell Rep 17:307–320. https://doi.org/10.1016/j.stemcr.2021.12.011

doi: 10.1016/j.stemcr.2021.12.011

Kropski JA, Richmond BW, Gaskill CF, Foronjy RF, Majka SM (2018) Deregulated angiogenesis in chronic lung diseases: a possible role for lung mesenchymal progenitor cells (2017 Grover Conference Series). Pulm Circ 8:2045893217739807. https://doi.org/10.1177/2045893217739807

doi: 10.1177/2045893217739807 pubmed: 29040010

Lagana SM, Kudose S, Iuga AC, Lee MJ, Fazlollahi L, Remotti HE, Del Portillo A, De Michele S, de Gonzalez AK, Saqi A, Khairallah P, Chong AM, Park H, Uhlemann AC, Lefkowitch JH, Verna EC (2020) Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data. Mod Pathol 33:2147–2155. https://doi.org/10.1038/s41379-020-00649-x

doi: 10.1038/s41379-020-00649-x pubmed: 32792598 pmcid: 7424245

Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RBG, Paul van Schayck J, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJH, Schipper D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL, Clevers H (2020) SARS-CoV-2 productively infects human gut enterocytes. Science 369:50–54. https://doi.org/10.1126/science.abc1669

doi: 10.1126/science.abc1669 pubmed: 32358202

Lax SF, Skok K, Zechner P, Kessler HH, Kaufmann N, Koelblinger C, Vander K, Bargfrieder U, Trauner M (2020) Pulmonary arterial thrombosis in COVID-19 with fatal outcome : results from a prospective, single-center, clinicopathologic case series. Ann Intern Med 173:350–361. https://doi.org/10.7326/M20-2566

doi: 10.7326/M20-2566 pubmed: 32422076

Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Sturzl M, Staats L, Mahajan A, Schauer C, Kremer AN, Volkl S, Amann K, Evert K, Falkeis C, Wehrfritz A, Rieker RJ, Hartmann A, Kremer AE, Neurath MF, Munoz LE, Schett G, Herrmann M (2020) Vascular occlusion by neutrophil extracellular traps in COVID-19. EBioMedicine 58:102925. https://doi.org/10.1016/j.ebiom.2020.102925

doi: 10.1016/j.ebiom.2020.102925 pubmed: 32745993 pmcid: 7397705

Lindner D, Fitzek A, Brauninger H, Aleshcheva G, Edler C, Meissner K, Scherschel K, Kirchhof P, Escher F, Schultheiss HP, Blankenberg S, Puschel K, Westermann D (2020) Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases. JAMA Cardiol 5:1281–1285. https://doi.org/10.1001/jamacardio.2020.3551

doi: 10.1001/jamacardio.2020.3551 pubmed: 32730555

Liu B, Li M, Zhou Z, Guan X, Xiang Y (2020) Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? J Autoimmun 111:102452. https://doi.org/10.1016/j.jaut.2020.102452

doi: 10.1016/j.jaut.2020.102452 pubmed: 32291137 pmcid: 7151347

Loscocco GG, Malandrino D, Barchiesi S, Berni A, Poggesi L, Guglielmelli P, Vannucchi AM (2020) The HScore for secondary hemophagocytic lymphohistiocytosis, calculated without a marrow biopsy, is consistently low in patients with COVID-19. Int J Lab Hematol 42:e270–e273. https://doi.org/10.1111/ijlh.13310

doi: 10.1111/ijlh.13310 pubmed: 32776691

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dorfler F, Kadler S, Rosowski J, Gurcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Muller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Rohmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C (2021) Cross-reactive CD4(+) T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. Science 374:eabh1823 https://doi.org/10.1126/science.abh1823

Lozada-Nur F, Chainani-Wu N, Fortuna G, Sroussi H (2020) Dysgeusia in COVID-19: possible mechanisms and implications. Oral Surg Oral Med Oral Pathol Oral Radiol 130:344–346. https://doi.org/10.1016/j.oooo.2020.06.016

doi: 10.1016/j.oooo.2020.06.016 pubmed: 32703719 pmcid: 7320705

Magro C, Mulvey JJ, Berlin D, Nuovo G, Salvatore S, Harp J, Baxter-Stoltzfus A, Laurence J (2020) Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases. Transl Res 220:1–13. https://doi.org/10.1016/j.trsl.2020.04.007

doi: 10.1016/j.trsl.2020.04.007 pubmed: 32299776 pmcid: 7158248

Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, Gabrilove JL, Sacks H (2021) Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evid Based Med 26:107–108. https://doi.org/10.1136/bmjebm-2020-111536

doi: 10.1136/bmjebm-2020-111536 pubmed: 32934000

Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 77:683–690. https://doi.org/10.1001/jamaneurol.2020.1127

doi: 10.1001/jamaneurol.2020.1127 pubmed: 32275288

Martines RB, Ritter JM, Matkovic E, Gary J, Bollweg BC, Bullock H, Goldsmith CS, Silva-Flannery L, Seixas JN, Reagan-Steiner S, Uyeki T, Denison A, Bhatnagar J, Shieh WJ, Zaki SR, Group C-PW (2020) Pathology and pathogenesis of SARS-CoV-2 associated with fatal coronavirus disease, United States. Emerg Infect Dis 26:2005–2015. https://doi.org/10.3201/eid2609.202095

Massoth LR, Desai N, Szabolcs A, Harris CK, Neyaz A, Crotty R, Chebib I, Rivera MN, Sholl LM, Stone JR, Ting DT, Deshpande V (2021) Comparison of RNA in situ hybridization and immunohistochemistry techniques for the detection and localization of SARS-CoV-2 in human tissues. Am J Surg Pathol 45:14–24. https://doi.org/10.1097/PAS.0000000000001563

doi: 10.1097/PAS.0000000000001563 pubmed: 32826529

Matschke J, Lutgehetmann M, Hagel C, Sperhake JP, Schroder AS, Edler C, Mushumba H, Fitzek A, Allweiss L, Dandri M, Dottermusch M, Heinemann A, Pfefferle S, Schwabenland M, Sumner Magruder D, Bonn S, Prinz M, Gerloff C, Puschel K, Krasemann S, Aepfelbacher M, Glatzel M (2020) Neuropathology of patients with COVID-19 in Germany: a post-mortem case series. Lancet Neurol 19:919–929. https://doi.org/10.1016/S1474-4422(20)30308-2

doi: 10.1016/S1474-4422(20)30308-2 pubmed: 33031735 pmcid: 7535629

Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, Across Speciality Collaboration UK (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395:1033–1034. https://doi.org/10.1016/S0140-6736(20)30628-0

doi: 10.1016/S0140-6736(20)30628-0 pubmed: 32192578 pmcid: 7270045

Meinhardt J, Radke J, Dittmayer C, Franz J, Thomas C, Mothes R, Laue M, Schneider J, Brunink S, Greuel S, Lehmann M, Hassan O, Aschman T, Schumann E, Chua RL, Conrad C, Eils R, Stenzel W, Windgassen M, Rossler L, Goebel HH, Gelderblom HR, Martin H, Nitsche A, Schulz-Schaeffer WJ, Hakroush S, Winkler MS, Tampe B, Scheibe F, Kortvelyessy P, Reinhold D, Siegmund B, Kuhl AA, Elezkurtaj S, Horst D, Oesterhelweg L, Tsokos M, Ingold-Heppner B, Stadelmann C, Drosten C, Corman VM, Radbruch H, Heppner FL (2021) Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. Nat Neurosci 24:168–175. https://doi.org/10.1038/s41593-020-00758-5

doi: 10.1038/s41593-020-00758-5 pubmed: 33257876

Meng B, Abdullahi A, Ferreira I, Goonawardane N, Saito A, Kimura I, Yamasoba D, Gerber PP, Fatihi S, Rathore S, Zepeda SK, Papa G, Kemp SA, Ikeda T, Toyoda M, Tan TS, Kuramochi J, Mitsunaga S, Ueno T, Shirakawa K, Takaori-Kondo A, Brevini T, Mallery DL, Charles OJ, Collaboration C-NBC-, Genotype to Phenotype Japan Consortium m, Ecuador CC, Bowen JE, Joshi A, Walls AC, Jackson L, Martin D, Smith KGC, Bradley J, Briggs JAG, Choi J, Madissoon E, Meyer K, Mlcochova P, Ceron-Gutierrez L, Doffinger R, Teichmann SA, Fisher AJ, Pizzuto MS, de Marco A, Corti D, Hosmillo M, Lee JH, James LC, Thukral L, Veesler D, Sigal A, Sampaziotis F, Goodfellow IG, Matheson NJ, Sato K, Gupta RK (2022) Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature https://doi.org/10.1038/s41586-022-04474-x

Menter T, Haslbauer JD, Nienhold R, Savic S, Hopfer H, Deigendesch N, Frank S, Turek D, Willi N, Pargger H, Bassetti S, Leuppi JD, Cathomas G, Tolnay M, Mertz KD, Tzankov A (2020) Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction. Histopathology 77:198–209. https://doi.org/10.1111/his.14134

doi: 10.1111/his.14134 pubmed: 32364264 pmcid: 7496150

Muller JA, Gross R, Conzelmann C, Kruger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Gruner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Munch J, Heller S, Kleger A (2021) SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nat Metab 3:149–165. https://doi.org/10.1038/s42255-021-00347-1

doi: 10.1038/s42255-021-00347-1 pubmed: 33536639

Nakayama T, Lee IT, Jiang S, Matter MS, Yan CH, Overdevest JB, Wu CT, Goltsev Y, Shih LC, Liao CK, Zhu B, Bai Y, Lidsky P, Xiao Y, Zarabanda D, Yang A, Easwaran M, Schurch CM, Chu P, Chen H, Stalder AK, McIlwain DR, Borchard NA, Gall PA, Dholakia SS, Le W, Xu L, Tai CJ, Yeh TH, Erickson-Direnzo E, Duran JM, Mertz KD, Hwang PH, Haslbauer JD, Jackson PK, Menter T, Andino R, Canoll PD, DeConde AS, Patel ZM, Tzankov A, Nolan GP, Nayak JV (2021) Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers. Cell Rep Med 2:100421. https://doi.org/10.1016/j.xcrm.2021.100421

doi: 10.1016/j.xcrm.2021.100421 pubmed: 34604819 pmcid: 8479532

Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M (2021) Pathophysiological mechanisms of liver injury in COVID-19. Liver Int 41:20–32. https://doi.org/10.1111/liv.14730

doi: 10.1111/liv.14730 pubmed: 33190346

Newell KL, Clemmer DC, Cox JB, Kayode YI, Zoccoli-Rodriguez V, Taylor HE, Endy TP, Wilmore JR, Winslow GM (2021) Switched and unswitched memory B cells detected during SARS-CoV-2 convalescence correlate with limited symptom duration. PLoS One 16:e0244855. https://doi.org/10.1371/journal.pone.0244855

doi: 10.1371/journal.pone.0244855 pubmed: 33507994 pmcid: 7843013

Nicholls JM, Poon LL, Lee KC, Ng WF, Lai ST, Leung CY, Chu CM, Hui PK, Mak KL, Lim W, Yan KW, Chan KH, Tsang NC, Guan Y, Yuen KY, Peiris JS (2003) Lung pathology of fatal severe acute respiratory syndrome. Lancet 361:1773–1778. https://doi.org/10.1016/s0140-6736(03)13413-7

doi: 10.1016/s0140-6736(03)13413-7 pubmed: 12781536 pmcid: 7112492

Nicolai L, Leunig A, Brambs S, Kaiser R, Joppich M, Hoffknecht ML, Gold C, Engel A, Polewka V, Muenchhoff M, Hellmuth JC, Ruhle A, Ledderose S, Weinberger T, Schulz H, Scherer C, Rudelius M, Zoller M, Keppler OT, Zwissler B, von Bergwelt-Baildon M, Kaab S, Zimmer R, Bulow RD, von Stillfried S, Boor P, Massberg S, Pekayvaz K, Stark K (2021) Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia. J Thromb Haemost 19:574–581. https://doi.org/10.1111/jth.15179

doi: 10.1111/jth.15179 pubmed: 33217134

Nie X, Qian L, Sun R, Huang B, Dong X, Xiao Q, Zhang Q, Lu T, Yue L, Chen S, Li X, Sun Y, Li L, Xu L, Li Y, Yang M, Xue Z, Liang S, Ding X, Yuan C, Peng L, Liu W, Yi X, Lyu M, Xiao G, Xu X, Ge W, He J, Fan J, Wu J, Luo M, Chang X, Pan H, Cai X, Zhou J, Yu J, Gao H, Xie M, Wang S, Ruan G, Chen H, Su H, Mei H, Luo D, Zhao D, Xu F, Li Y, Zhu Y, Xia J, Hu Y, Guo T (2021) Multi-organ proteomic landscape of COVID-19 autopsies. Cell 184(775–791):e714. https://doi.org/10.1016/j.cell.2021.01.004

doi: 10.1016/j.cell.2021.01.004

Nunez-Torron C, Ferrer-Gomez A, Moreno Moreno E, Perez-Mies B, Villarrubia J, Chamorro S, Lopez-Jimenez J, Palacios J, Piris-Villaespesa M, Garcia-Cosio M (2021) Secondary haemophagocytic lymphohistiocytosis in COVID-19: correlation of the autopsy findings of bone marrow haemophagocytosis with HScore. J Clin Pathol https://doi.org/10.1136/jclinpath-2020-207337

Paizis G, Tikellis C, Cooper ME, Schembri JM, Lew RA, Smith AI, Shaw T, Warner FJ, Zuilli A, Burrell LM, Angus PW (2005) Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 54:1790–1796. https://doi.org/10.1136/gut.2004.062398

doi: 10.1136/gut.2004.062398 pubmed: 16166274 pmcid: 1774784

Park A, Iwasaki A (2020) Type I and type III interferons—induction, signaling, evasion, and application to combat COVID-19 cell host. Microbe 27:870–878. https://doi.org/10.1016/j.chom.2020.05.008

doi: 10.1016/j.chom.2020.05.008

Parolin M, Parisotto M, Zanchetta F, Sartorato P, De Menis E (2021) Coronaviruses and endocrine system: a systematic review on evidence and shadows. Endocr Metab Immune Disord Drug Targets 21:1242–1251. https://doi.org/10.2174/1871530320666200905123332

doi: 10.2174/1871530320666200905123332 pubmed: 32888287

Perico L, Benigni A, Casiraghi F, Ng LFP, Renia L, Remuzzi G (2021) Immunity, endothelial injury and complement-induced coagulopathy in COVID-19. Nat Rev Nephrol 17:46–64. https://doi.org/10.1038/s41581-020-00357-4

doi: 10.1038/s41581-020-00357-4 pubmed: 33077917

Polak SB, Van Gool IC, Cohen D, von der Thusen JH, van Paassen J (2020) A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression. Mod Pathol 33:2128–2138. https://doi.org/10.1038/s41379-020-0603-3

doi: 10.1038/s41379-020-0603-3 pubmed: 32572155 pmcid: 7306927

Porcari A, Bussani R, Merlo M, Varra GG, Pagura L, Rozze D, Sinagra G (2021) Incidence and characterization of concealed cardiac amyloidosis among unselected elderly patients undergoing post-mortem examination. Front Cardiovasc Med 8:749523. https://doi.org/10.3389/fcvm.2021.749523

doi: 10.3389/fcvm.2021.749523 pubmed: 34888361 pmcid: 8649842

Price LC, McCabe C, Garfield B, Wort SJ (2020) Thrombosis and COVID-19 pneumonia: the clot thickens! Eur Respir J 56 https://doi.org/10.1183/13993003.01608-2020

Prieto-Perez L, Fortes J, Soto C, Vidal-Gonzalez A, Alonso-Riano M, Lafarga M, Cortti MJ, Lazaro-Garcia A, Perez-Tanoira R, Trascasa A, Antonio A, Cordoba R, Rodriguez-Pinilla SM, Cedeno O, Peces-Barba G, Fernandez-Ormaechea I, Diez Medrano MJ, de Las Lopez, Heras M, Cabello A, Petkova E, Alvarez B, Carrillo I, Silva AM, Castellanos M, Calpena S, Valverde-Monge M, Fresneda D, Rubio-Martin R, Cornejo I, Blanco Astilleros, de Cordova L, de la Fuente S, Recuero S, Gorgolas M, Piris MA (2020) Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection. Mod Pathol 33:2139–2146. https://doi.org/10.1038/s41379-020-0613-1

doi: 10.1038/s41379-020-0613-1 pubmed: 32620916 pmcid: 7333227

Prilutskiy A, Kritselis M, Shevtsov A, Yambayev I, Vadlamudi C, Zhao Q, Kataria Y, Sarosiek SR, Lerner A, Sloan JM, Quillen K, Burks EJ (2020) SARS-CoV-2 infection-associated hemophagocytic lymphohistiocytosis. Am J Clin Pathol 154:466–474. https://doi.org/10.1093/ajcp/aqaa124

doi: 10.1093/ajcp/aqaa124 pubmed: 32681166

Proal AD, VanElzakker MB (2021) Long COVID or post-acute sequelae of COVID-19 (PASC): an overview of biological factors that may contribute to persistent symptoms. Front Microbiol 12:698169. https://doi.org/10.3389/fmicb.2021.698169

doi: 10.3389/fmicb.2021.698169 pubmed: 34248921 pmcid: 8260991

Puelles VG, Lutgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schroder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB (2020) Multiorgan and renal tropism of SARS-CoV-2. N Engl J Med 383:590–592. https://doi.org/10.1056/NEJMc2011400

doi: 10.1056/NEJMc2011400 pubmed: 32402155

Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E (2020) Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19). JAMA Cardiol 5:1265–1273. https://doi.org/10.1001/jamacardio.2020.3557

doi: 10.1001/jamacardio.2020.3557 pubmed: 32730619 pmcid: 7385689

Raptis CA, Hammer MM, Short RG, Shah A, Bhalla S, Bierhals AJ, Filev PD, Hope MD, Jeudy J, Kligerman SJ, Henry TS (2020) Chest CT and coronavirus disease (COVID-19): a critical review of the literature to date. AJR Am J Roentgenol 215:839–842. https://doi.org/10.2214/AJR.20.23202

doi: 10.2214/AJR.20.23202 pubmed: 32298149

Remmelink M, De Mendonca R, D’Haene N, De Clercq S, Verocq C, Lebrun L, Lavis P, Racu ML, Trepant AL, Maris C, Rorive S, Goffard JC, De Witte O, Peluso L, Vincent JL, Decaestecker C, Taccone FS, Salmon I (2020) Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients. Crit Care 24:495. https://doi.org/10.1186/s13054-020-03218-5

doi: 10.1186/s13054-020-03218-5 pubmed: 32787909 pmcid: 7422463

Sapino A, Facchetti F, Bonoldi E, Gianatti A, Barbareschi M, Societa Italiana di Anatomia Patologica e Citologia S (2020) The autopsy debate during the COVID-19 emergency: the Italian experience. Virchows Arch 476:821–823 https://doi.org/10.1007/s00428-020-02828-2

Scappaticcio L, Pitoia F, Esposito K, Piccardo A, Trimboli P (2020) Impact of COVID-19 on the thyroid gland: an update. Rev Endocr Metab Disord https://doi.org/10.1007/s11154-020-09615-z

Schaller T, Hirschbuhl K, Burkhardt K, Braun G, Trepel M, Markl B, Claus R (2020) Postmortem Examination of Patients With COVID-19. JAMA 323:2518–2520. https://doi.org/10.1001/jama.2020.8907

doi: 10.1001/jama.2020.8907 pubmed: 32437497 pmcid: 7243161

Schulte-Schrepping J, Reusch N, Paclik D, Bassler K, Schlickeiser S, Zhang B, Kramer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Muller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jurgens L, Stegemann M, Glosenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Handler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE, Deutsche C-OI (2020) Severe COVID-19 is marked by a dysregulated myeloid cell compartment. Cell 182:1419–1440 e1423 https://doi.org/10.1016/j.cell.2020.08.001

Schwabenland M, Salie H, Tanevski J, Killmer S, Lago MS, Schlaak AE, Mayer L, Matschke J, Puschel K, Fitzek A, Ondruschka B, Mei HE, Boettler T, Neumann-Haefelin C, Hofmann M, Breithaupt A, Genc N, Stadelmann C, Saez-Rodriguez J, Bronsert P, Knobeloch KP, Blank T, Thimme R, Glatzel M, Prinz M, Bengsch B (2021) Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions. Immunity 54(1594–1610):e1511. https://doi.org/10.1016/j.immuni.2021.06.002

doi: 10.1016/j.immuni.2021.06.002

Sekulic M, Harper H, Nezami BG, Shen DL, Sekulic SP, Koeth AT, Harding CV, Gilmore H, Sadri N (2020) Molecular Detection of SARS-CoV-2 Infection in FFPE samples and histopathologic findings in fatal SARS-CoV-2 cases. Am J Clin Pathol 154:190–200. https://doi.org/10.1093/ajcp/aqaa091

doi: 10.1093/ajcp/aqaa091 pubmed: 32451533

Solomon IH, Normandin E, Bhattacharyya S, Mukerji SS, Keller K, Ali AS, Adams G, Hornick JL, Padera RF Jr, Sabeti P (2020) Neuropathological features of Covid-19. N Engl J Med 383:989–992. https://doi.org/10.1056/NEJMc2019373

doi: 10.1056/NEJMc2019373 pubmed: 32530583

Song J, Li Y, Huang X, Chen Z, Li Y, Liu C, Chen Z, Duan X (2020) Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2. J Med Virol 92:2556–2566. https://doi.org/10.1002/jmv.26045

doi: 10.1002/jmv.26045 pubmed: 32441816 pmcid: 7280739

Studart-Neto A, Guedes BF, Tuma RLE, Camelo Filho AE, Kubota GT, Iepsen BD, Moreira GP, Rodrigues JC, Ferrari MMH, Carra RB, Spera RR, Oku MHM, Terrim S, Lopes CCB, Passos Neto CEB, Fiorentino MD, JCC DES, Baima JPS, TFF DAS, Moreno CAM, Silva AMS, Heise CO, MendonCa RH, Fortini I, Smid J, Adoni T, GonCalves MRR, Pereira SLA, Pinto LF, Gomes HR, Zanoteli E, Brucki SMD, Conforto AB, Castro LHM, Nitrini R (2020) Neurological consultations and diagnoses in a large, dedicated COVID-19 university hospital. Arq Neuropsiquiatr 78:494–500 https://doi.org/10.1590/0004-282X20200089

Sugiyama MG, Gamage A, Zyla R, Armstrong SM, Advani S, Advani A, Wang C, Lee WL (2016) Influenza virus infection induces platelet-endothelial adhesion which contributes to lung injury. J Virol 90:1812–1823. https://doi.org/10.1128/JVI.02599-15

doi: 10.1128/JVI.02599-15 pubmed: 26637453 pmcid: 4733979

Taquet M, Geddes JR, Husain M, Luciano S, Harrison PJ (2021) 6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records. Lancet Psychiatry 8:416–427. https://doi.org/10.1016/S2215-0366(21)00084-5

doi: 10.1016/S2215-0366(21)00084-5 pubmed: 33836148 pmcid: 8023694

Tavazzi G, Pellegrini C, Maurelli M, Belliato M, Sciutti F, Bottazzi A, Sepe PA, Resasco T, Camporotondo R, Bruno R, Baldanti F, Paolucci S, Pelenghi S, Iotti GA, Mojoli F, Arbustini E (2020) Myocardial localization of coronavirus in COVID-19 cardiogenic shock. Eur J Heart Fail 22:911–915. https://doi.org/10.1002/ejhf.1828

doi: 10.1002/ejhf.1828 pubmed: 32275347

Thompson BT, Chambers RC, Liu KD (2017) Acute respiratory distress syndrome. N Engl J Med 377:1904–1905. https://doi.org/10.1056/NEJMc1711824

doi: 10.1056/NEJMc1711824 pubmed: 29117492

Tiwari NR, Phatak S, Sharma VR, Agarwal SK (2021) COVID-19 and thrombotic microangiopathies. Thromb Res 202:191–198. https://doi.org/10.1016/j.thromres.2021.04.012

doi: 10.1016/j.thromres.2021.04.012 pubmed: 33894421 pmcid: 8055926

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H (2020) Endothelial cell infection and endotheliitis in COVID-19. Lancet 395:1417–1418. https://doi.org/10.1016/S0140-6736(20)30937-5

doi: 10.1016/S0140-6736(20)30937-5 pubmed: 32325026 pmcid: 7172722

von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bulow RD, Burrig KF, Holtherm HU, Jonigk D, Knuchel R, Majeed RW, Rohrig R, Wienstroer J, Boor P (2021) Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs). Pathologe https://doi.org/10.1007/s00292-020-00897-3

von Stillfried S, Boor P (2021) Detection methods for SARS-CoV-2 in tissue. Pathologe https://doi.org/10.1007/s00292-021-00920-1

von Stillfried S, Bülow RD, Röhrig R, Boor P, Böcker J, Schmidt J, Tholen P, Majeed R, Wienströer J, Weis J, Bremer J, Knüchel R, Breitbach A, Cacchi C, Freeborn B, Wucherpfennig S, Spring O, Braun G, Römmele C, Märkl B, Claus R, Dhillon C, Schaller T, Sipos E, Hirschbühl K, Wittmann M, Kling E, Kröncke T, Heppner FL, Meinhardt J, Radbruch H, Streit S, Horst D, Elezkurtaj S, Quaas A, Göbel H, Hansen T, Titze U, Lorenzen J, Reuter T, Woloszyn J, Baretton G, Hilsenbeck J, Meinhardt M, Pablik J, Sommer L, Holotiuk O, Meinel M, Mahlke N, Esposito I, Crudele G, Seidl M, Amann KU, Coras R, Hartmann A, Eichhorn P, Haller F, Lange F, Schmid KW, Ingenwerth M, Rawitzer J, Theegarten D, Birngruber CG, Wild P, Gradhand E, Smith K, Werner M, Schilling O, Acker T, Gattenlöhner S, Stadelmann C, Metz I, Franz J, Stork L, Thomas C, Zechel S, Ströbel P, Wickenhauser C, Fathke C, Harder A, Ondruschka B, Dietz E, Edler C, Fitzek A, Fröb D, Heinemann A, Heinrich F, Klein A, Kniep I, Lohner L, Möbius D, Püschel K, Schädler J, Schröder A-S, Sperhake J-P, Aepfelbacher M, Fischer N, Lütgehetmann M, Pfefferle S, Glatzel M, Krasemann S, Matschke J, Jonigk D, Werlein C, Schirmacher P, Domke LM, Hartmann L, Klein IM, Schwab C, Röcken C, Friemann J, Langer D, Roth W, Strobl S, Rudelius M, Stock KF, Weichert W, Delbridge C, Kasajima A, Kuhn P-H, Slotta-Huspenina J, Weirich G, Barth P, Wardelmann E, Evert K, Büttner A, Manhart J, Nigbur S, Bittmann I, Fend F, Bösmüller H, Granai M, Klingel K, Warm V, Steinestel K, Umathum VG, Rosenwald A, Kurz F, Vogt N (2022) First report from the German COVID-19 autopsy registry. Lancet Reg Health - Europe https://doi.org/10.1016/j.lanepe.2022.100330

von Stillfried S, Bulow RD, Rohrig R, Knuchel-Clarke R, Boor P, DeRegCovid (2020) Autopsy registry can facilitate COVID-19 research. EMBO Mol Med 12:e12885. https://doi.org/10.15252/emmm.202012885

doi: 10.15252/emmm.202012885

Wang MY, Zhao R, Gao LJ, Gao XF, Wang DP, Cao JM (2020) SARS-CoV-2: Structure, biology, and structure-based therapeutics development. Front Cell Infect Microbiol 10:587269. https://doi.org/10.3389/fcimb.2020.587269

Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, Tan W (2020) Detection of SARS-CoV-2 in Different types of clinical specimens. JAMA 323:1843–1844. https://doi.org/10.1001/jama.2020.3786

doi: 10.1001/jama.2020.3786 pubmed: 32159775 pmcid: 7066521

Wei JF, Huang FY, Xiong TY, Liu Q, Chen H, Wang H, Huang H, Luo YC, Zhou X, Liu ZY, Peng Y, Xu YN, Wang B, Yang YY, Liang ZA, Lei XZ, Ge Y, Yang M, Zhang L, Zeng MQ, Yu H, Liu K, Jia YH, Prendergast BD, Li WM, Chen M (2020) Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis. Heart 106:1154–1159. https://doi.org/10.1136/heartjnl-2020-317007

doi: 10.1136/heartjnl-2020-317007 pubmed: 32354798

Wenzel P, Kopp S, Gobel S, Jansen T, Geyer M, Hahn F, Kreitner KF, Escher F, Schultheiss HP, Munzel T (2020) Evidence of SARS-CoV-2 mRNA in endomyocardial biopsies of patients with clinically suspected myocarditis tested negative for COVID-19 in nasopharyngeal swab. Cardiovasc Res 116:1661–1663. https://doi.org/10.1093/cvr/cvaa160

doi: 10.1093/cvr/cvaa160 pubmed: 32562489

Werion A, Belkhir L, Perrot M, Schmit G, Aydin S, Chen Z, Penaloza A, De Greef J, Yildiz H, Pothen L, Yombi JC, Dewulf J, Scohy A, Gerard L, Wittebole X, Laterre PF, Miller SE, Devuyst O, Jadoul M, Morelle J, Cliniques universitaires Saint-Luc C-RG, (2020) SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule. Kidney Int 98:1296–1307. https://doi.org/10.1016/j.kint.2020.07.019

doi: 10.1016/j.kint.2020.07.019 pubmed: 32791255 pmcid: 7416689

Wichmann D, Sperhake JP, Lutgehetmann M, Steurer S, Edler C, Heinemann A, Heinrich F, Mushumba H, Kniep I, Schroder AS, Burdelski C, de Heer G, Nierhaus A, Frings D, Pfefferle S, Becker H, Bredereke-Wiedling H, de Weerth A, Paschen HR, Sheikhzadeh-Eggers S, Stang A, Schmiedel S, Bokemeyer C, Addo MM, Aepfelbacher M, Puschel K, Kluge S (2020) Autopsy findings and venous thromboembolism in patients with COVID-19: a prospective cohort study. Ann Intern Med 173:268–277. https://doi.org/10.7326/M20-2003

doi: 10.7326/M20-2003 pubmed: 32374815

Wildner NH, Ahmadi P, Schulte S, Brauneck F, Kohsar M, Lutgehetmann M, Beisel C, Addo MM, Haag F, Schulze Zur Wiesch J (2021) B cell analysis in SARS-CoV-2 versus malaria: increased frequencies of plasmablasts and atypical memory B cells in COVID-19. J Leukoc Biol 109:77–90. https://doi.org/10.1002/JLB.5COVA0620-370RR

doi: 10.1002/JLB.5COVA0620-370RR pubmed: 33617048

Wolfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Muller MA, Niemeyer D, Jones TC, Vollmar P, Rothe C, Hoelscher M, Bleicker T, Brunink S, Schneider J, Ehmann R, Zwirglmaier K, Drosten C, Wendtner C (2020) Virological assessment of hospitalized patients with COVID-2019. Nature 581:465–469. https://doi.org/10.1038/s41586-020-2196-x

doi: 10.1038/s41586-020-2196-x pubmed: 32235945

Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM et al (2021) Multisystemic cellular tropism of SARS-CoV-2 in autopsies of COVID-19 patients. Cells 10(8):1900. https://doi.org/10.3390/cells10081900

Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK (2021) SARS-CoV-2 infects human pancreatic beta cells and elicits beta cell impairment. Cell Metab 33(1565–1576):e1565. https://doi.org/10.1016/j.cmet.2021.05.013

doi: 10.1016/j.cmet.2021.05.013

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, Tai Y, Bai C, Gao T, Song J, Xia P, Dong J, Zhao J, Wang FS (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med 8:420–422. https://doi.org/10.1016/S2213-2600(20)30076-X

doi: 10.1016/S2213-2600(20)30076-X pubmed: 32085846 pmcid: 7164771

Yachou Y, El Idrissi A, Belapasov V, Ait Benali S (2020) Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients. Neurol Sci 41:2657–2669. https://doi.org/10.1007/s10072-020-04575-3

doi: 10.1007/s10072-020-04575-3 pubmed: 32725449 pmcid: 7385206

Yanagihara T, Jones KD (2020) Demystifying morphomolecular alterations of vasculature in interstitial lung diseases. Eur Respir J 55 https://doi.org/10.1183/13993003.02446-2019

Yang AC, Kern F, Losada PM, Agam MR, Maat CA, Schmartz GP, Fehlmann T, Stein JA, Schaum N, Lee DP, Calcuttawala K, Vest RT, Berdnik D, Lu N, Hahn O, Gate D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T (2021) Dysregulation of brain and choroid plexus cell types in severe COVID-19. Nature 595:565–571. https://doi.org/10.1038/s41586-021-03710-0

doi: 10.1038/s41586-021-03710-0 pubmed: 34153974 pmcid: 8400927

Yang J, Chen T, Zhou Y (2021) Mediators of SARS-CoV-2 entry are preferentially enriched in cardiomyocytes. Hereditas 158:4. https://doi.org/10.1186/s41065-020-00168-4

doi: 10.1186/s41065-020-00168-4 pubmed: 33397514 pmcid: 7781406

Yu CM, Wong RS, Wu EB, Kong SL, Wong J, Yip GW, Soo YO, Chiu ML, Chan YS, Hui D, Lee N, Wu A, Leung CB, Sung JJ (2006) Cardiovascular complications of severe acute respiratory syndrome. Postgrad Med J 82:140–144. https://doi.org/10.1136/pgmj.2005.037515

doi: 10.1136/pgmj.2005.037515 pubmed: 16461478 pmcid: 2596695

Zeng JH, Liu YX, Yuan J, Wang FX, Wu WB, Li JX, Wang LF, Gao H, Wang Y, Dong CF, Li YJ, Xie XJ, Feng C, Liu L (2020) First case of COVID-19 complicated with fulminant myocarditis: a case report and insights. Infection 48:773–777. https://doi.org/10.1007/s15010-020-01424-5

doi: 10.1007/s15010-020-01424-5 pubmed: 32277408 pmcid: 7146072

Zhang H, Kang ZJ, Gong HY, Xu D, Wang J, Li ZX, Li ZF, Cui XG, Xiao JR, Zhan J, Meng T, Zhou W, Liu JM, Xu HJ (2020) Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. Gut 69:1010–1018. https://doi.org/10.1136/gutjnl-2020-320953

doi: 10.1136/gutjnl-2020-320953

Zhang L, Wang Y, Wu G, Xiong W, Gu W, Wang CY (2018) Macrophages: friend or foe in idiopathic pulmonary fibrosis? Respir Res 19:170. https://doi.org/10.1186/s12931-018-0864-2

doi: 10.1186/s12931-018-0864-2 pubmed: 30189872 pmcid: 6127991

Zhang Q, Bastard P, Liu Z, Le Pen J, Moncada-Velez M, Chen J, Ogishi M, Sabli IKD, Hodeib S, Korol C, Rosain J, Bilguvar K, Ye J, Bolze A, Bigio B, Yang R, Arias AA, Zhou Q, Zhang Y, Onodi F, Korniotis S, Karpf L, Philippot Q, Chbihi M, Bonnet-Madin L, Dorgham K, Smith N, Schneider WM, Razooky BS, Hoffmann HH, Michailidis E, Moens L, Han JE, Lorenzo L, Bizien L, Meade P, Neehus AL, Ugurbil AC, Corneau A, Kerner G, Zhang P, Rapaport F, Seeleuthner Y, Manry J, Masson C, Schmitt Y, Schluter A, Le Voyer T, Khan T, Li J, Fellay J, Roussel L, Shahrooei M, Alosaimi MF, Mansouri D, Al-Saud H, Al-Mulla F, Almourfi F, Al-Muhsen SZ, Alsohime F, Al Turki S, Hasanato R, van de Beek D, Biondi A, Bettini LR, D’Angio M, Bonfanti P, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Oler AJ, Tompkins MF, Alba C, Vandernoot I, Goffard JC, Smits G, Migeotte I, Haerynck F, Soler-Palacin P, Martin-Nalda A, Colobran R, Morange PE, Keles S, Colkesen F, Ozcelik T, Yasar KK, Senoglu S, Karabela SN, Rodriguez-Gallego C, Novelli G, Hraiech S, Tandjaoui-Lambiotte Y, Duval X, Laouenan C, Clinicians C-S, Clinicians C, Imagine CG, French CCSG, Co VCC, Amsterdam UMCC-B, Effort CHG, Group N-UTCI, Snow AL, Dalgard CL, Milner JD, Vinh DC, Mogensen TH, Marr N, Spaan AN, Boisson B, Boisson-Dupuis S, Bustamante J, Puel A, Ciancanelli MJ, Meyts I, Maniatis T, Soumelis V, Amara A, Nussenzweig M, Garcia-Sastre A, Krammer F, Pujol A, Duffy D, Lifton RP, Zhang SY, Gorochov G, Beziat V, Jouanguy E, Sancho-Shimizu V, Rice CM, Abel L, Notarangelo LD, Cobat A, Su HC, Casanova JL (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370 https://doi.org/10.1126/science.abd4570

Zhao CL, Rapkiewicz A, Maghsoodi-Deerwester M, Gupta M, Cao W, Palaia T, Zhou J, Ram B, Vo D, Rafiee B, Hossein-Zadeh Z, Dabiri B, Hanna I (2021) Pathological findings in the postmortem liver of patients with coronavirus disease 2019 (COVID-19). Hum Pathol 109:59–68. https://doi.org/10.1016/j.humpath.2020.11.015

doi: 10.1016/j.humpath.2020.11.015 pubmed: 33307078

Zheng YY, Ma YT, Zhang JY, Xie X (2020) COVID-19 and the cardiovascular system. Nat Rev Cardiol 17:259–260. https://doi.org/10.1038/s41569-020-0360-5

doi: 10.1038/s41569-020-0360-5 pubmed: 32139904 pmcid: 7095524

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, Guan L, Wei Y, Li H, Wu X, Xu J, Tu S, Zhang Y, Chen H, Cao B (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054–1062. https://doi.org/10.1016/S0140-6736(20)30566-3

doi: 10.1016/S0140-6736(20)30566-3 pubmed: 32171076 pmcid: 7270627

Zhou L, Niu Z, Jiang X, Zhang Z, Zheng Y, Wang Z, Zhu Y, Gao L, Huang H, Wang X, Sun Q (2020) SARS-CoV-2 Targets by the pscRNA profiling of ACE2, TMPRSS2 and Furin proteases. iScience 23:101744 https://doi.org/10.1016/j.isci.2020.101744

Zippi M, Hong W, Traversa G, Maccioni F, De Biase D, Gallo C, Fiorino S (2020) Involvement of the exocrine pancreas during COVID-19 infection and possible pathogenetic hypothesis: a concise review. Infez Med 28:507–515

pubmed: 33257624

Zuo Y, Yalavarthi S, Shi H, Gockman K, Zuo M, Madison JA, Blair C, Weber A, Barnes BJ, Egeblad M, Woods RJ, Kanthi Y, Knight JS (2020) Neutrophil extracellular traps in COVID-19. JCI Insight 5 https://doi.org/10.1172/jci.insight.138999

Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?

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