Label free identification of the different status of anemia disease using optimized double-slot cascaded microring resonator.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
received:
16
01
2022
accepted:
23
03
2022
entrez:
2
4
2022
pubmed:
3
4
2022
medline:
6
4
2022
Statut:
epublish
Résumé
An optical-based label-free biosensors including two indirectly coupled double-slot-waveguide-based microring resonator was designed and optimized for sensing purpose. Then, the optimized system was applied for the detection of hemoglobin concentration in anemia disease. The results were simulated based on the variational finite-difference time domain (varFDTD) method using the Lumerical software (Mode solutions) and the optimum geometrical parameters were determined to realize an optimum light transmission via the sensor. Nine different concentrations of hemoglobin in men and women were applied into the sensor and the status of anemia was identified based on the patients' gender and different status of anemia disease, including the normal, mild, moderate, severe and life-threatening status. A sensitivity as high as 1024 nm/RIU with the minimum deflection limit of 4.88 × 10
Identifiants
pubmed: 35365740
doi: 10.1038/s41598-022-09504-2
pii: 10.1038/s41598-022-09504-2
pmc: PMC8975812
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5548Informations de copyright
© 2022. The Author(s).
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