Cutaneous presentation of enteropathy-associated T-cell lymphoma masquerading as a DUSP22-rearranged CD30+ lymphoproliferation.
Dual-Specificity Phosphatases
/ genetics
Enteropathy-Associated T-Cell Lymphoma
/ diagnosis
Female
Humans
Ki-1 Antigen
Lymphoma, Large-Cell, Anaplastic
/ diagnosis
Lymphoma, T-Cell, Peripheral
Middle Aged
Mitogen-Activated Protein Kinase Phosphatases
/ genetics
Receptor Protein-Tyrosine Kinases
/ genetics
Skin Neoplasms
/ diagnosis
CD30-positive lymphoproliferative disorder
Celiac disease
Cutaneous
DUSP22
Enteropathy-associated T-cell lymphoma
Skin ulcer
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
15
02
2022
accepted:
07
03
2022
revised:
03
03
2022
pubmed:
3
4
2022
medline:
12
10
2022
entrez:
2
4
2022
Statut:
ppublish
Résumé
DUSP22 gene rearrangements are recurrent in systemic and cutaneous ALK-negative anaplastic large cell lymphomas, rarely encountered in other cutaneous CD30+ lymphoproliferations, and typically absent in other peripheral T-cell lymphomas. We report the case of a 51-year-old woman, with longstanding celiac disease and a rapidly enlarging leg ulcer, due to a DUSP22-rearranged CD30+ T-cell lymphoproliferation. Subsequent history revealed an intestinal enteropathy-associated T-cell lymphoma (EATL). Identical monoclonal TR gene rearrangements and mutations in STAT3 and JAK1 typical of EATL were present in the cutaneous and intestinal lesions. No DUSP22 rearrangement was detected in the patient's intestinal tumour, nor in 15 additional EATLs tested. These findings indicate that DUSP22 rearrangements are not entirely specific of ALCLs, may rarely occur as a secondary aberration in EATL, and expand the differential diagnosis of DUSP22-rearranged cutaneous CD30+ lymphoproliferative disorders.
Identifiants
pubmed: 35366115
doi: 10.1007/s00428-022-03309-4
pii: 10.1007/s00428-022-03309-4
doi:
Substances chimiques
Ki-1 Antigen
0
Receptor Protein-Tyrosine Kinases
EC 2.7.10.1
Mitogen-Activated Protein Kinase Phosphatases
EC 3.1.3.16
DUSP22 protein, human
EC 3.1.3.48
Dual-Specificity Phosphatases
EC 3.1.3.48
Types de publication
Case Reports
Editorial
Langues
eng
Sous-ensembles de citation
IM
Pagination
653-657Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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