Clinical Prognostic Implications of Wnt Hub Genes Expression in Medulloblastoma.
Bioinformatics tools
Biomarkers
Hub genes
Molecular Subgroups
Therapeutic targets
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
13
07
2021
accepted:
22
03
2022
pubmed:
3
4
2022
medline:
3
3
2023
entrez:
2
4
2022
Statut:
ppublish
Résumé
Medulloblastoma is the most common type of pediatric malignant primary brain tumor, and about one-third of patients die due to disease recurrence and most survivors suffer from long-term side effects. MB is clinically, genetically, and epigenetically heterogeneous and subdivided into at least four molecular subgroups: WNT, SHH, Group 3, and Group 4. We evaluated common differentially expressed genes between a Brazilian RNA-seq GSE181293 dataset and microarray GSE85217 dataset cohort of pediatric MB samples using bioinformatics methodology in order to identify hub genes of the molecular subgroups based on PPI network construction, survival and functional analysis. The main finding was the identification of five hub genes from the WNT subgroup that are tumor suppressors, and whose lower expression is related to a worse prognosis for MB patients. Furthermore, the common genes correlated with the five tumor suppressors participate in important pathways and processes for tumor initiation and progression, as well as development and differentiation, and some of them control cell stemness and pluripotency. These genes have not yet been studied within the context of MB, representing new important elements for investigation in the search for therapeutic targets, prognostic markers or for understanding of MB biology.
Identifiants
pubmed: 35366170
doi: 10.1007/s10571-022-01217-4
pii: 10.1007/s10571-022-01217-4
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
813-826Subventions
Organisme : fundação de amparo à pesquisa do estado de são paulo
ID : 2014/20341-0
Organisme : coordenação de aperfeiçoamento de pessoal de nível superior
ID : 88882.317618/2019-01
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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