Circulating Levels of Endothelin-1 and Big Endothelin-1 in Patients with Essential Hypertension.
big endothelin-1
endothelin-1
essential hypertension
Journal
Pathophysiology : the official journal of the International Society for Pathophysiology
ISSN: 1873-149X
Titre abrégé: Pathophysiology
Pays: Switzerland
ID NLM: 9433813
Informations de publication
Date de publication:
25 Oct 2021
25 Oct 2021
Historique:
received:
04
09
2021
revised:
15
10
2021
accepted:
21
10
2021
entrez:
2
4
2022
pubmed:
3
4
2022
medline:
3
4
2022
Statut:
epublish
Résumé
The role of endothelin-1 (ET-1) in the pathogenesis of hypertension (HTN) is not clearly established. There is evidence that its circulating levels are elevated in some forms of experimental and human HTN, but this was not a consistent finding. Based on these controversial data, we tested serum levels of ET-1 and Big ET-1 (the precursor of ET-1) in patients with essential HTN, comparing the results with those of healthy normotensive controls. The levels of ET-1 and Big ET-1 were measured by ELISA. Our results in patients with essential HTN showed that the mean levels of ET-1 (5.01 ± 2.1 pg/mL) were significantly higher (
Identifiants
pubmed: 35366246
pii: pathophysiology28040031
doi: 10.3390/pathophysiology28040031
pmc: PMC8830463
doi:
Types de publication
Journal Article
Langues
eng
Pagination
489-495Références
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