Risk Stratification in Post-ERCP Pancreatitis: How Do Procedures, Patient Characteristics and Clinical Indicators Influence Outcomes?
ALT
AST
ERCP
bilirubin
lipase
pancreatitis
Journal
Pathophysiology : the official journal of the International Society for Pathophysiology
ISSN: 1873-149X
Titre abrégé: Pathophysiology
Pays: Switzerland
ID NLM: 9433813
Informations de publication
Date de publication:
20 Feb 2021
20 Feb 2021
Historique:
received:
12
12
2020
revised:
24
01
2021
accepted:
31
01
2021
entrez:
2
4
2022
pubmed:
20
2
2021
medline:
20
2
2021
Statut:
epublish
Résumé
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains common, and severe complications are associated with ERCP. There is no previous study detailing the effect of race and gender in a US-based population on risk of PEP. Data were collected on 269 "first-performed" consecutive ERCPs followed by division by race (White vs. African-American) and sex (Female vs. Male). A total of 53 probable risk factors were evaluated by uni- and multivariate analysis followed by outcomes expressed as an odds ratio (OR) (with a 95% confidence interval, 95% CI). Finally, a principal component analysis was performed to construct a risk prediction model for PEP, which can be used by clinicians at bedside. After analyzing the risk factors based on race and gender-based groups, Caucasian males with PEP are more likely to have prior history of pancreatitis ( It is very evident that both patient and procedure-related risk factors vary by race and gender in the US population, leading to the development of a new risk assessment tool for PEP that can be used in clinical practice. We need to follow up with a larger prospective study to validate this novel race and gender-based risk scoring system for PEP.
Sections du résumé
BACKGROUND
BACKGROUND
Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remains common, and severe complications are associated with ERCP. There is no previous study detailing the effect of race and gender in a US-based population on risk of PEP.
METHODS
METHODS
Data were collected on 269 "first-performed" consecutive ERCPs followed by division by race (White vs. African-American) and sex (Female vs. Male). A total of 53 probable risk factors were evaluated by uni- and multivariate analysis followed by outcomes expressed as an odds ratio (OR) (with a 95% confidence interval, 95% CI). Finally, a principal component analysis was performed to construct a risk prediction model for PEP, which can be used by clinicians at bedside.
RESULTS
RESULTS
After analyzing the risk factors based on race and gender-based groups, Caucasian males with PEP are more likely to have prior history of pancreatitis (
CONCLUSIONS
CONCLUSIONS
It is very evident that both patient and procedure-related risk factors vary by race and gender in the US population, leading to the development of a new risk assessment tool for PEP that can be used in clinical practice. We need to follow up with a larger prospective study to validate this novel race and gender-based risk scoring system for PEP.
Identifiants
pubmed: 35366271
pii: pathophysiology28010007
doi: 10.3390/pathophysiology28010007
pmc: PMC8830468
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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