Mathematical Modeling of Ion Quantum Tunneling Reveals Novel Properties of Voltage-Gated Channels and Quantum Aspects of Their Pathophysiology in Excitability-Related Disorders.
arrhythmias
epilepsy
pain
potassium ions
quantum biology
quantum biophysics
quantum tunneling
sodium ions
voltage-gated channel
Journal
Pathophysiology : the official journal of the International Society for Pathophysiology
ISSN: 1873-149X
Titre abrégé: Pathophysiology
Pays: Switzerland
ID NLM: 9433813
Informations de publication
Date de publication:
07 Mar 2021
07 Mar 2021
Historique:
received:
05
02
2021
revised:
03
03
2021
accepted:
04
03
2021
entrez:
2
4
2022
pubmed:
3
4
2022
medline:
3
4
2022
Statut:
epublish
Résumé
Voltage-gated channels are crucial in action potential initiation and propagation and there are many diseases and disorders related to them. Additionally, the classical mechanics are the main mechanics used to describe the function of the voltage-gated channels and their related abnormalities. However, the quantum mechanics should be considered to unravel new aspects in the voltage-gated channels and resolve the problems and challenges that classical mechanics cannot solve. In the present study, the aim is to mathematically show that quantum mechanics can exhibit a powerful tendency to unveil novel electrical features in voltage-gated channels and be used as a promising tool to solve the problems and challenges in the pathophysiology of excitability-related diseases. The model of quantum tunneling of ions through the intracellular hydrophobic gate is used to evaluate the influence of membrane potential and gating free energy on the tunneling probability, single channel conductance, and quantum membrane conductance. This evaluation is mainly based on graphing the mathematical relationships between these variables. The obtained mathematical graphs showed that ions can achieve significant quantum membrane conductance, which can affect the resting membrane potential and the excitability of cells. In the present work, quantum mechanics reveals original electrical properties associated with voltage-gated channels and introduces new insights and implications into the pathophysiology of excitability- related disorders. In addition, the present work sets a mathematical and theoretical framework that can be utilized to conduct experimental studies in order to explore the quantum aspects of voltage-gated channels and the quantum bioelectrical property of biological membranes.
Identifiants
pubmed: 35366274
pii: pathophysiology28010010
doi: 10.3390/pathophysiology28010010
pmc: PMC8830480
doi:
Types de publication
Journal Article
Langues
eng
Pagination
116-154Déclaration de conflit d'intérêts
The author declares no conflict of interest.
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