A systematic review and meta-analysis of the impact of the left atrial appendage closure on left atrial function.
WATCHMAN device
amulet device
atrial function
left atrial appendage closure
left atrial emptying fraction
left atrium function
Journal
Clinical cardiology
ISSN: 1932-8737
Titre abrégé: Clin Cardiol
Pays: United States
ID NLM: 7903272
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
31
01
2022
accepted:
20
03
2022
pubmed:
3
4
2022
medline:
10
6
2022
entrez:
2
4
2022
Statut:
ppublish
Résumé
Left atrial (LA) appendage closure (LAAC) is effective in patients with atrial fibrillation who are not candidates for long-term anticoagulation. However, the impact of LAAC on LA function is unknown. The aim of this study is to evaluate the impact of LAAC on atrial function. This meta-analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search strategy was designed to utilize PubMed/Medline, EMBASE, and Google scholar for studies showing the effect of LAAC on the LA function from inception to November 20, 2021. The standardized mean difference (SMD) was calculated from the means and standard deviations. Of 247 studies initially identified, 8 studies comprising 260 patients were included in the final analysis. There was a significant increase in LA emptying fraction following LAAC compared with preoperative function (SMD: 0.53; 95% confidence interval [CI]: 0.04-1.01; p = .03; I LAAC is associated with improvement in the left atrial emptying fraction, but did not significantly influence other parameters.
Sections du résumé
BACKGROUND
BACKGROUND
Left atrial (LA) appendage closure (LAAC) is effective in patients with atrial fibrillation who are not candidates for long-term anticoagulation. However, the impact of LAAC on LA function is unknown. The aim of this study is to evaluate the impact of LAAC on atrial function.
METHODS
METHODS
This meta-analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A search strategy was designed to utilize PubMed/Medline, EMBASE, and Google scholar for studies showing the effect of LAAC on the LA function from inception to November 20, 2021. The standardized mean difference (SMD) was calculated from the means and standard deviations.
RESULTS
RESULTS
Of 247 studies initially identified, 8 studies comprising 260 patients were included in the final analysis. There was a significant increase in LA emptying fraction following LAAC compared with preoperative function (SMD: 0.53; 95% confidence interval [CI]: 0.04-1.01; p = .03; I
CONCLUSION
CONCLUSIONS
LAAC is associated with improvement in the left atrial emptying fraction, but did not significantly influence other parameters.
Identifiants
pubmed: 35366380
doi: 10.1002/clc.23824
pmc: PMC9175246
doi:
Types de publication
Journal Article
Meta-Analysis
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
614-621Informations de copyright
© 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.
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