FIRE-9 - PORT / AIO-KRK-0418: a prospective, randomized, open, multicenter Phase III trial to investigate the efficacy of adjuvant/additive chemotherapy in patients with definitely-treated metastatic colorectal cancer.


Journal

BMC cancer
ISSN: 1471-2407
Titre abrégé: BMC Cancer
Pays: England
ID NLM: 100967800

Informations de publication

Date de publication:
02 Apr 2022
Historique:
received: 09 12 2021
accepted: 17 03 2022
entrez: 3 4 2022
pubmed: 4 4 2022
medline: 6 4 2022
Statut: epublish

Résumé

Additive/adjuvant chemotherapy as concept after local treatment of colorectal metastases has not been proven to be successful by phase III trials. Accordingly, a standard of care to improve relapse rates and long-term survival is not established and adjuvant chemotherapy cannot be recommended as a standard therapy due to limited evidence in literature. The PORT trial aims to generate evidence that post-resection/ablation/radiation chemotherapy improves the survival in patients with metastatic colorectal cancer. Patients to be included into this trial must have synchronous or metachronous metastases of colorectal cancer-either resected (R0 or R1) and/or effectively treated by ablation or radiation within 3-10 weeks before randomization-and have the primary tumor resected, without radiographic evidence of active metastatic disease at study entry. The primary endpoint of the trial is progression-free survival after 24 months, secondary endpoints include overall survival, safety, quality of life, treatments (including efficacy) beyond study participation, translational endpoints, and others. One arm of the study comprising 2/3 of the population will be treated for 6 months with modified FOLFOXIRI or modified FOLFOX6 (investigator´s choice, depending on the performance status of the patients but determined before randomization), while the other arm (1/3 of the population) will be observed and undergo scheduled follow-up computed tomography scans according to the interventional arm. Optimal oncological management after removal of colorectal metastases is unclear. The PORT trial aims to generate evidence that additive/adjuvant chemotherapy after definitive treatment of colorectal metastases improves progression free and overall survival in patients with colorectal cancer. This study is registered with clinicaltrials.gov ( NCT05008809 ) and EudraCT (2020-006,144-18).

Sections du résumé

BACKGROUND BACKGROUND
Additive/adjuvant chemotherapy as concept after local treatment of colorectal metastases has not been proven to be successful by phase III trials. Accordingly, a standard of care to improve relapse rates and long-term survival is not established and adjuvant chemotherapy cannot be recommended as a standard therapy due to limited evidence in literature. The PORT trial aims to generate evidence that post-resection/ablation/radiation chemotherapy improves the survival in patients with metastatic colorectal cancer.
METHODS METHODS
Patients to be included into this trial must have synchronous or metachronous metastases of colorectal cancer-either resected (R0 or R1) and/or effectively treated by ablation or radiation within 3-10 weeks before randomization-and have the primary tumor resected, without radiographic evidence of active metastatic disease at study entry. The primary endpoint of the trial is progression-free survival after 24 months, secondary endpoints include overall survival, safety, quality of life, treatments (including efficacy) beyond study participation, translational endpoints, and others. One arm of the study comprising 2/3 of the population will be treated for 6 months with modified FOLFOXIRI or modified FOLFOX6 (investigator´s choice, depending on the performance status of the patients but determined before randomization), while the other arm (1/3 of the population) will be observed and undergo scheduled follow-up computed tomography scans according to the interventional arm.
DISCUSSION CONCLUSIONS
Optimal oncological management after removal of colorectal metastases is unclear. The PORT trial aims to generate evidence that additive/adjuvant chemotherapy after definitive treatment of colorectal metastases improves progression free and overall survival in patients with colorectal cancer.
TRIAL REGISTRATION BACKGROUND
This study is registered with clinicaltrials.gov ( NCT05008809 ) and EudraCT (2020-006,144-18).

Identifiants

pubmed: 35366831
doi: 10.1186/s12885-022-09422-6
pii: 10.1186/s12885-022-09422-6
pmc: PMC8976276
doi:

Banques de données

ClinicalTrials.gov
['NCT05008809']

Types de publication

Clinical Trial, Phase III Journal Article Multicenter Study Randomized Controlled Trial

Langues

eng

Sous-ensembles de citation

IM

Pagination

359

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : MO 2667/2-1

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nathanael Raschzok (N)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany.

Sebastian Stintzing (S)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.

Volker Heinemann (V)

German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany.
Department of Medical Oncology, Munich & Comprehensive Cancer Center, LMU University Hospital, Munich, Germany.

Geraldine Rauch (G)

Institute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Jens Ricke (J)

Department of Radiology, LMU University Hospital, Munich, Germany.

Matthias Guckenberger (M)

Department for Radiation Oncology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

Annika Kurreck (A)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Annabel H S Alig (AHS)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Arndt Stahler (A)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Lars Bullinger (L)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Moritz Schmelzle (M)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Wenzel Schöning (W)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Georg Lurje (G)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Felix Krenzien (F)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Academy, Clinician Scientist Program, Berlin, Germany.

Oliver Haase (O)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Beate Rau (B)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Bernhard Gebauer (B)

Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.

Igor M Sauer (IM)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Johann Pratschke (J)

Department of Surgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Campus Charité Mitte | Campus Virchow-Klinikum, Berlin, Germany.

Dominik P Modest (DP)

Department of Hematoogy, Oncology, and Cancer Immunology (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany. dominik.modest@charite.de.
German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany. dominik.modest@charite.de.

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