Elective Deliveries and the Risk of Autism.

Autism Spectrum Disorder / epidemiology Autistic Disorder Cesarean Section / adverse effects Delivery, Obstetric / adverse effects Female Humans Infant, Newborn Pregnancy Retrospective Studies

Journal

American journal of preventive medicine
ISSN: 1873-2607
Titre abrégé: Am J Prev Med
Pays: Netherlands
ID NLM: 8704773

Informations de publication

Date de publication:
07 2022
Historique:
received: 28 07 2021
revised: 04 01 2022
accepted: 19 01 2022
pubmed: 4 4 2022
medline: 23 6 2022
entrez: 3 4 2022
Statut: ppublish

Résumé

Cesarean section and induced deliveries have increased substantially in the U.S., coinciding with increases in autism spectrum disorder. Studies have documented associations between cesarean section deliveries and autism spectrum disorder but have not comprehensively accounted for medical risks. This study evaluates the extent to which cesarean section and induced deliveries are associated with autism spectrum disorder in low-risk births. In this retrospective cohort study, California's birth records (1992-2012) were linked to hospital discharge records to identify low-risk births using a stringent algorithm based on Joint Commission guidelines. Autism spectrum disorder status was based on California Department of Developmental Service data. Logistic regression models were used to estimate associations between autism spectrum disorder and induced vaginal deliveries, cesarean section deliveries not following induction, and cesarean section deliveries following induction, with noninduced vaginal deliveries as the reference category. A total of 1,488,425 low-risk births took place in California from 1992 to 2012. The adjusted odds of autism spectrum disorder were 7% higher for induced vaginal deliveries (AOR=1.07, 95% CI=1.01, 1.14), 26% higher for cesarean section deliveries not following induction (AOR=1.26, 95% CI=1.19, 1.33), and 31% higher for cesarean section deliveries following induction (AOR=1.31, 95% CI=1.18, 1.45) than for noninduced vaginal deliveries. Lower gestational age and neonatal morbidities did not appear to be important underlying pathways. The associations were insensitive to alternative model specifications and across subpopulations. These results suggest that, in low-risk pregnancies, up to 10% of autism spectrum disorder cases are potentially preventable by avoiding cesarean section deliveries. After accounting for medical risks, elective deliveries-particularly cesarean section deliveries-were associated with a substantially increased risk of autism spectrum disorder.

Identifiants

DOI: 10.1016/j.amepre.2022.01.024 PMID: 35367106 PMC: PMC9232972
pubmed: 35367106
pii: S0749-3797(22)00108-8
doi: 10.1016/j.amepre.2022.01.024
pmc: PMC9232972
mid: NIHMS1788550
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

68-76

Subventions

Organisme : NICHD NIH HHS
ID : P2C HD041022
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD058486
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD090119
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003017
Pays : United States

Informations de copyright

Copyright © 2022 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

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Auteurs

Ka-Yuet Liu (KY)

Department of Sociology, College of Social Sciences, University of California, Los Angeles, Los Angeles, California; California Center for Population Research, College of Social Sciences, University of California, Los Angeles, Los Angeles, California; RIKEN Center for Brain Science (CBS), Wako, Japan. Electronic address: kayuet.liu@riken.jp.

Julien O Teitler (JO)

School of Social Work, Columbia University, New York, New York.

Sivananda Rajananda (S)

California Center for Population Research, College of Social Sciences, University of California, Los Angeles, Los Angeles, California.

Valentina Chegwin (V)

School of Social Work, Columbia University, New York, New York.

Peter S Bearman (PS)

Department of Sociology, Columbia University in the City of New York, New York, New York.

Thomas Hegyi (T)

Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey.

Nancy E Reichman (NE)

Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, New Jersey.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie obstétrique › Accouchement (procédure) › Césarienne › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie obstétrique › Accouchement (procédure) › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Elective Deliveries and the Risk of Autism.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Elective Deliveries and the Risk of Autism.