Associations of Maternal Prenatal Stress and Depressive Symptoms With Childhood Neurobehavioral Outcomes in the ECHO Cohort of the NICHD Fetal Growth Studies: Fetal Growth Velocity as a Potential Mediator.
fetal growth velocity
neurobehavior
neurodevelopment
prenatal stress
psychiatric problems
Journal
Journal of the American Academy of Child and Adolescent Psychiatry
ISSN: 1527-5418
Titre abrégé: J Am Acad Child Adolesc Psychiatry
Pays: United States
ID NLM: 8704565
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
06
05
2021
revised:
27
01
2022
accepted:
21
03
2022
pubmed:
4
4
2022
medline:
1
9
2022
entrez:
3
4
2022
Statut:
ppublish
Résumé
Maternal prenatal stress and mood symptoms are associated with risk for child psychopathology. Within the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth Studies (ECHO-FGS), a racially and ethnically diverse cohort, we studied associations between prenatal stress and depressive symptoms with child neurobehavior, and potential mediation by fetal growth velocity (FGV) in low-risk pregnancies. For 730 mother-child pairs, we had serial ultrasound measurements, self-reports of prenatal stress and depression, observations of child executive functions and motor skills from 4 to 8 years, and maternal reports of child psychiatric problems. We tested associations between prenatal stress and depressive symptoms with child neurobehavior in regression analyses, and associations with FGV in mixed effect models. Post hoc we tested severity of prenatal symptoms; FGV at 25 Prenatal stress and depressive symptoms were associated with child psychiatric problems, and prenatal depressive symptoms with decrements in executive functions and motor skills, especially in biological male children. Neither prenatal stress nor depressive symptoms were associated with FGV. In one of the largest cohorts with observed child outcomes, and the first with broad representation of race and ethnicity in the United States, we found that prenatal stress and depressive symptoms were associated with greater reports of child psychiatric symptoms. Only prenatal depressive symptoms were associated with observed decrements in cognitive abilities, most significantly in biological male children. Stress during low-risk pregnancies may be less detrimental than theorized. There was no mediation by FGV. These findings support the need to attend to even small changes in prenatal distress, as these may have long-lasting implications.
Identifiants
pubmed: 35367322
pii: S0890-8567(22)00175-7
doi: 10.1016/j.jaac.2022.03.021
pmc: PMC9427685
mid: NIHMS1799049
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1155-1167Subventions
Organisme : NICHD NIH HHS
ID : HHSN275201000009C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275200800014C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275200800028C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275200800013C
Pays : United States
Organisme : NICHD NIH HHS
ID : HHSN275200800012C
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023316
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001450
Pays : United States
Informations de copyright
Copyright © 2022 American Academy of Child and Adolescent Psychiatry. All rights reserved.
Références
Early Hum Dev. 1996 Feb 23;44(2):139-51
pubmed: 8745426
PLoS Med. 2015 Dec 15;12(12):e1001918
pubmed: 26671224
Int J Epidemiol. 2018 Feb 1;47(1):25-25l
pubmed: 29025016
Child Dev. 2016 Jan-Feb;87(1):211-20
pubmed: 26462448
Res Dev Disabil. 2014 Feb;35(2):357-63
pubmed: 24333806
Cultur Divers Ethnic Minor Psychol. 2007 Jan;13(1):18-25
pubmed: 17227173
Dev Psychopathol. 2014 May;26(2):393-403
pubmed: 24621564
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
J Affect Disord. 1996 Jul 29;39(3):185-9
pubmed: 8856422
BMC Psychiatry. 2014 Oct 08;14:284
pubmed: 25293375
JAMA. 2021 Aug 17;326(7):621-627
pubmed: 34402850
J Am Acad Child Adolesc Psychiatry. 2007 Oct;46(10):1324-1332
pubmed: 17885574
J Am Acad Child Adolesc Psychiatry. 2021 Jan;60(1):186-197
pubmed: 32278003
Arch Womens Ment Health. 2019 Jun;22(3):349-355
pubmed: 30069707
J Abnorm Psychol. 2017 Jan;126(1):137-148
pubmed: 27748619
Curr Psychiatry Rep. 2018 Sep 18;20(11):102
pubmed: 30229468
J Autism Dev Disord. 2017 Nov;47(11):3550-3561
pubmed: 28856480
BMJ. 2020 Nov 11;371:m4022
pubmed: 33177069
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
J Cardiopulm Rehabil. 2003 Nov-Dec;23(6):398-403
pubmed: 14646785
J Affect Disord. 2017 Jan 01;207:9-17
pubmed: 27665073
Stress. 2011 Nov;14(6):665-76
pubmed: 21995526
Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6
pubmed: 23479538
Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64
pubmed: 23479546
Am J Obstet Gynecol. 2015 Oct;213(4):449.e1-449.e41
pubmed: 26410205
J Affect Disord. 2012 Feb;136(3):680-92
pubmed: 22036793
PLoS One. 2013 May 21;8(5):e63109
pubmed: 23704892
Am J Psychiatry. 2017 Apr 1;174(4):319-328
pubmed: 27838934
J Dev Behav Pediatr. 2014 Jan;35(1):38-43
pubmed: 24345757
Soc Psychiatry Psychiatr Epidemiol. 2013 Aug;48(8):1335-45
pubmed: 23248031
Dev Psychobiol. 2014 Jan;56(1):117-25
pubmed: 23143986
Neurosci Biobehav Rev. 2020 Oct;117:26-64
pubmed: 28757456
Am J Obstet Gynecol. 2017 Jul;217(1):82.e1-82.e7
pubmed: 28263750
Am J Obstet Gynecol. 2018 Sep;219(3):285.e1-285.e36
pubmed: 29803819
Adv Child Dev Behav. 2019;57:1-25
pubmed: 31296312
J Clin Psychiatry. 2011 Mar;72(3):378-87
pubmed: 21208585
Biol Psychiatry. 2016 May 15;79(10):831-839
pubmed: 26444076
Am J Obstet Gynecol. 1985 Feb 1;151(3):333-7
pubmed: 3881966
J Am Acad Child Adolesc Psychiatry. 2017 May;56(5):373-382
pubmed: 28433086
Neuroimage. 2018 Dec;183:828-835
pubmed: 30189341
Pediatrics. 2015 Sep;136(3):e599-608
pubmed: 26304830
Res Dev Disabil. 2014 Nov 6;36C:338-357
pubmed: 25462494
Am J Psychiatry. 2016 Jul 1;173(7):705-13
pubmed: 27013342
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):23996-24005
pubmed: 31611411
Dialogues Clin Neurosci. 2016 Dec;18(4):459-464
pubmed: 28179817
J Child Psychol Psychiatry. 2016 Apr;57(4):491-501
pubmed: 26616637
Dev Psychol. 2017 Apr;53(4):629-641
pubmed: 28333525
JAMA Psychiatry. 2022 Jan 1;79(1):70-74
pubmed: 34613345
Am J Obstet Gynecol. 2016 Aug;215(2):221.e1-221.e16
pubmed: 27143399