Spata7 is required for maintenance of the retinal connecting cilium.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
02 04 2022
02 04 2022
Historique:
received:
13
01
2022
accepted:
22
03
2022
entrez:
3
4
2022
pubmed:
4
4
2022
medline:
6
4
2022
Statut:
epublish
Résumé
SPATA7, an early onset LCA3 retinal disease gene, encodes a putative scaffold protein that is essential for the proper assembly of the connecting cilium (CC) complex in photoreceptors. Previous studies have shown that SPATA7 interacts with other photoreceptor-specific ciliary proteins, such as RPGR and RPGRIP1, and maintains the integrity of CC integrity. However, although it is known that Spata7 is required for early formation of the CC, it is unclear if Spata7 is also required for the maintenance of the CC. To investigate Spata7 function in the retina at the adult stage, loss of function was induced in the adult retina upon tamoxifen induction of an inducible Spata7 knockout allele (Spata7
Identifiants
pubmed: 35368022
doi: 10.1038/s41598-022-09530-0
pii: 10.1038/s41598-022-09530-0
pmc: PMC8976851
doi:
Substances chimiques
DNA-Binding Proteins
0
SPATA7 protein, mouse
0
Rhodopsin
9009-81-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5575Subventions
Organisme : NEI NIH HHS
ID : R01 EY028970
Pays : United States
Organisme : NIH HHS
ID : R01EY020540
Pays : United States
Organisme : NIH HHS
ID : R01EY018571
Pays : United States
Organisme : NIH HHS
ID : R01EY022356
Pays : United States
Informations de copyright
© 2022. The Author(s).
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