Organization of Presynaptic Autophagy-Related Processes.
Bassoon
active zone (AZ)
amphisome
autophagy
endocytic zone
endolysosomal system
presynaptic proteostasis
synaptic vesicle (SV)
Journal
Frontiers in synaptic neuroscience
ISSN: 1663-3563
Titre abrégé: Front Synaptic Neurosci
Pays: Switzerland
ID NLM: 101548972
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
12
2021
accepted:
04
01
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Brain synapses pose special challenges on the quality control of their protein machineries as they are far away from the neuronal soma, display a high potential for plastic adaptation and have a high energy demand to fulfill their physiological tasks. This applies in particular to the presynaptic part where neurotransmitter is released from synaptic vesicles, which in turn have to be recycled and refilled in a complex membrane trafficking cycle. Pathways to remove outdated and damaged proteins include the ubiquitin-proteasome system acting in the cytoplasm as well as membrane-associated endolysosomal and the autophagy systems. Here we focus on the latter systems and review what is known about the spatial organization of autophagy and endolysomal processes within the presynapse. We provide an inventory of which components of these degradative systems were found to be present in presynaptic boutons and where they might be anchored to the presynaptic apparatus. We identify three presynaptic structures reported to interact with known constituents of membrane-based protein-degradation pathways and therefore may serve as docking stations. These are (i) scaffolding proteins of the cytomatrix at the active zone, such as Bassoon or Clarinet, (ii) the endocytic machinery localized mainly at the peri-active zone, and (iii) synaptic vesicles. Finally, we sketch scenarios, how presynaptic autophagic cargos are tagged and recruited and which cellular mechanisms may govern membrane-associated protein turnover in the presynapse.
Identifiants
pubmed: 35368245
doi: 10.3389/fnsyn.2022.829354
pmc: PMC8968026
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
829354Informations de copyright
Copyright © 2022 Gundelfinger, Karpova, Pielot, Garner and Kreutz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Cell Sci. 2006 Sep 15;119(Pt 18):3888-900
pubmed: 16940348
J Cell Biol. 2021 Mar 1;220(3):
pubmed: 33439214
Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14489-94
pubmed: 17726112
Nature. 2007 Jun 28;447(7148):1121-5
pubmed: 17589504
Nat Commun. 2017 May 31;8:15637
pubmed: 28561066
Neuron. 2014 Sep 3;83(5):1131-43
pubmed: 25155956
J Cell Sci. 2019 May 15;132(10):
pubmed: 31092635
EMBO Rep. 2020 Sep 3;21(9):e49801
pubmed: 32627320
J Biol Chem. 2005 May 27;280(21):20722-9
pubmed: 15778222
J Cell Sci. 2014 Aug 1;127(Pt 15):3280-93
pubmed: 24906799
EMBO J. 2017 May 15;36(10):1392-1411
pubmed: 28331029
J Mol Biol. 2020 Apr 3;432(8):2589-2604
pubmed: 31866297
PLoS Biol. 2016 Sep 29;14(9):e1002563
pubmed: 27684064
Bioessays. 2016 Jul;38 Suppl 1:S119-35
pubmed: 27417116
Autophagy. 2020 Sep;16(9):1651-1667
pubmed: 31876243
Sci Rep. 2020 Jul 21;10(1):12057
pubmed: 32694577
J Cell Sci. 2017 Oct 15;130(20):3507-3516
pubmed: 28860117
EMBO J. 2010 Feb 3;29(3):606-18
pubmed: 20010695
J Cell Sci. 2021 Feb 10;134(3):
pubmed: 33468622
Annu Rev Cell Dev Biol. 2019 Oct 6;35:477-500
pubmed: 31340124
J Cell Sci. 2014 Aug 15;127(Pt 16):3488-504
pubmed: 24928900
Adv Exp Med Biol. 2019;1206:527-550
pubmed: 31777002
Mol Cell Neurosci. 2021 Apr;112:103602
pubmed: 33581237
Mol Cell. 2009 Feb 27;33(4):505-16
pubmed: 19250911
Elife. 2019 Jul 16;8:
pubmed: 31309927
Science. 2020 Sep 4;369(6508):
pubmed: 32883836
Autophagy. 2021 May;17(5):1112-1130
pubmed: 32543313
J Cell Biol. 2017 Jul 3;216(7):1895-1906
pubmed: 28515275
Curr Opin Neurobiol. 2012 Jun;22(3):423-30
pubmed: 22030346
Cell. 2007 Sep 7;130(5):943-57
pubmed: 17803915
Nat Rev Mol Cell Biol. 2011 Jul 22;12(8):517-33
pubmed: 21779028
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):E181; author reply E182
pubmed: 21115811
J Bacteriol. 2000 Apr;182(8):2125-33
pubmed: 10735854
J Neurosci. 2008 Jul 2;28(27):6926-37
pubmed: 18596167
PLoS One. 2008 Jan 23;3(1):e1487
pubmed: 18213395
Cell Rep. 2019 Jul 2;28(1):51-64.e4
pubmed: 31269450
J Neurosci. 2016 Jun 1;36(22):5933-45
pubmed: 27251616
Nature. 2015 Apr 23;520(7548):563-6
pubmed: 25686604
Curr Opin Neurobiol. 2018 Aug;51:80-85
pubmed: 29549710
Front Mol Neurosci. 2017 Jun 21;10:177
pubmed: 28680391
J Biol Chem. 2018 Mar 23;293(12):4575-4576
pubmed: 29572327
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16982-7
pubmed: 20833817
Neuron. 2012 Sep 6;75(5):762-77
pubmed: 22958818
Front Synaptic Neurosci. 2013 Oct 17;5:8
pubmed: 24146648
Front Cell Dev Biol. 2020 Jan 21;7:373
pubmed: 32039200
Front Synaptic Neurosci. 2016 Jan 12;7:19
pubmed: 26793095
Nat Commun. 2017 Oct 30;8(1):678
pubmed: 29084947
Neuron. 2012 Apr 26;74(2):277-84
pubmed: 22542182
Immunity. 2017 Mar 21;46(3):405-420
pubmed: 28314591
J Neurochem. 2013 Oct;127(1):48-56
pubmed: 23815291
Front Synaptic Neurosci. 2012 Jun 25;4:1
pubmed: 22737123
Nat Cell Biol. 2016 Aug;18(8):839-850
pubmed: 27398910
PLoS One. 2013 Dec 13;8(12):e83324
pubmed: 24349490
Hum Mol Genet. 2018 Sep 15;27(18):3165-3176
pubmed: 29893844
Nature. 2015 Jan 22;517(7535):460-5
pubmed: 25517094
Small GTPases. 2019 Jan;10(1):54-63
pubmed: 28129039
EMBO Rep. 2015 Aug;16(8):923-38
pubmed: 26160654
Nat Cell Biol. 2021 May;23(5):450-456
pubmed: 33903736
Nat Commun. 2019 Nov 1;10(1):5017
pubmed: 31676756
Neural Dev. 2016 Mar 23;11:8
pubmed: 27008623
Neuron. 2013 Feb 6;77(3):425-39
pubmed: 23395371
EMBO J. 2013 Apr 3;32(7):954-69
pubmed: 23403927
Cells. 2016 Feb 06;5(1):
pubmed: 26861397
Nature. 2006 Oct 19;443(7113):780-6
pubmed: 17051204
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
EMBO J. 2016 Mar 15;35(6):561-79
pubmed: 26888746
Neuron. 2012 Jul 12;75(1):11-25
pubmed: 22794257
Cell. 1999 Oct 15;99(2):179-88
pubmed: 10535736
Nat Struct Mol Biol. 2020 Dec;27(12):1194-1201
pubmed: 33106659
Cell Death Differ. 2020 Dec;27(12):3386-3388
pubmed: 33177618
Neuron. 2019 Jul 17;103(2):217-234.e4
pubmed: 31171447
Curr Opin Cell Biol. 2020 Apr;63:102-113
pubmed: 32036294
J Cell Biol. 2021 Jul 5;220(7):
pubmed: 33988678
Autophagy. 2021 Dec;17(12):4491-4493
pubmed: 34520329
Autophagy. 2008 Jul;4(5):590-9
pubmed: 18497567
J Neurosci. 2016 Aug 17;36(33):8668-86
pubmed: 27535913
Mol Biol Cell. 2021 Nov 1;32(21):ar25
pubmed: 34432492
J Cell Biol. 2021 Sep 6;220(9):
pubmed: 34383013
Nature. 2010 Jul 1;466(7302):68-76
pubmed: 20562859
Nat Cell Biol. 2010 Aug;12(8):747-57
pubmed: 20639872
Neuron. 2022 Mar 2;110(5):824-840.e10
pubmed: 35065714
J Neurosci. 2014 Dec 3;34(49):16544-9
pubmed: 25471590
J Neurosci. 2019 Mar 20;39(12):2163-2183
pubmed: 30655355
Nat Cell Biol. 2018 Mar;20(3):233-242
pubmed: 29476151
Autophagy. 2018;14(5):796-811
pubmed: 29099309
Neuropsychopharmacology. 2008 Jan;33(1):18-41
pubmed: 17728696
Trends Cell Biol. 2016 Jan;26(1):6-16
pubmed: 26437584
Curr Opin Neurobiol. 2019 Dec;59:207-212
pubmed: 31634675
Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18530-18539
pubmed: 32690699
J Cell Sci. 2018 Sep 3;131(17):
pubmed: 30177506
Neurobiol Dis. 2019 Feb;122:64-71
pubmed: 29723605
Cell Mol Life Sci. 2021 Feb;78(4):1545-1563
pubmed: 32651614
Neuron. 2018 Sep 19;99(6):1216-1232.e7
pubmed: 30174114
Trends Biochem Sci. 2017 Nov;42(11):873-886
pubmed: 28947091
Curr Opin Neurobiol. 2018 Feb;48:153-159
pubmed: 29316491
Front Synaptic Neurosci. 2018 Oct 24;10:37
pubmed: 30405388
Autophagy. 2021 Oct;17(10):2680-2688
pubmed: 32924745
Dev Cell. 2014 Jul 14;30(1):71-85
pubmed: 25026034
Cell Rep. 2020 Jun 16;31(11):107775
pubmed: 32553155
Elife. 2021 Mar 05;10:
pubmed: 33666175
Autophagy. 2019 Jul;15(7):1199-1213
pubmed: 30744518
Biochim Biophys Acta Mol Cell Res. 2021 Apr;1868(4):118954
pubmed: 33422617
Nat Struct Mol Biol. 2020 Dec;27(12):1185-1193
pubmed: 33106658
EMBO J. 2016 Feb 1;35(3):281-301
pubmed: 26711178
FEBS J. 2021 Jul 17;:
pubmed: 34273246
Physiol Rev. 2015 Oct;95(4):1157-87
pubmed: 26269525
Nature. 2008 Feb 28;451(7182):1069-75
pubmed: 18305538
Cell Discov. 2020 May 5;6:23
pubmed: 32377373
Autophagy. 2015;11(10):1833-48
pubmed: 26325487
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11121-6
pubmed: 21690395
Cell Rep. 2016 Oct 18;17(4):1071-1086
pubmed: 27720640
Mol Neurodegener. 2013 Jul 08;8:23
pubmed: 23829673
Neuron. 2016 Mar 2;89(5):910-26
pubmed: 26938440
Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2955-E2964
pubmed: 28320970
Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381
pubmed: 29626215
J Neurochem. 2021 Apr;157(2):263-296
pubmed: 32964462
Biochem Soc Trans. 2021 Nov 1;49(5):2063-2072
pubmed: 34495322
Neuron. 2013 Apr 24;78(2):285-97
pubmed: 23622064
Trends Cell Biol. 2017 Jul;27(7):491-504
pubmed: 28169082
Adv Biosyst. 2019 Jan;3(1):e1800259
pubmed: 32627344
Curr Opin Neurobiol. 2021 Aug;69:76-83
pubmed: 33744822
Mol Biol Cell. 2014 Apr;25(8):1327-37
pubmed: 24554770
Cell Death Differ. 2018 May;25(5):918-934
pubmed: 29229996
Neuron. 2015 Nov 18;88(4):735-48
pubmed: 26590345
J Biol Chem. 2010 Mar 19;285(12):8595-604
pubmed: 20061386
Cell Commun Signal. 2012 Mar 13;10(1):7
pubmed: 22413737
Cell Mol Life Sci. 2021 Mar;78(6):2621-2639
pubmed: 33340068
Neuron. 2021 Jan 20;109(2):299-313.e9
pubmed: 33157003
EMBO J. 2019 Mar 1;38(5):
pubmed: 30733243
EMBO J. 2017 Sep 15;36(18):2790-2807
pubmed: 28848034
J Cell Biol. 2000 Feb 7;148(3):465-80
pubmed: 10662773
Mol Brain. 2019 Nov 29;12(1):100
pubmed: 31783880
Neuron. 2017 Feb 22;93(4):897-913.e7
pubmed: 28231469
Elife. 2017 Nov 21;6:
pubmed: 29160205
Mol Cell. 2021 Jan 7;81(1):13-24.e7
pubmed: 33202250
Neuron. 2021 Jan 6;109(1):27-41
pubmed: 33098763
Mol Cell. 2013 Aug 8;51(3):283-96
pubmed: 23911927
Hum Mol Genet. 2017 Aug 1;26(15):2933-2948
pubmed: 28482024
Autophagy. 2020 Mar;16(3):531-547
pubmed: 31204559
FEBS J. 2020 Jan;287(2):222-238
pubmed: 31693781
Elife. 2019 May 10;8:
pubmed: 31074746
Curr Opin Cell Biol. 2020 Aug;65:50-57
pubmed: 32203894
Front Synaptic Neurosci. 2016 May 24;8:12
pubmed: 27252645
J Cereb Blood Flow Metab. 2018 Nov;38(11):1924-1939
pubmed: 29972341
J Neurochem. 2021 Aug;158(3):589-602
pubmed: 33372296
Autophagy. 2010 Aug;6(6):702-10
pubmed: 20534972
Elife. 2020 May 04;9:
pubmed: 32364493
Biol Psychiatry. 2020 May 1;87(9):787-796
pubmed: 31542152
Biochim Biophys Acta. 2013 Mar;1833(3):503-10
pubmed: 23220125
Neuron. 2010 Oct 6;68(1):73-86
pubmed: 20920792
Mol Cell Biol. 2015 Sep 1;35(17):3044-58
pubmed: 26100023
Nat Rev Mol Cell Biol. 2003 Feb;4(2):127-39
pubmed: 12563290
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317
pubmed: 29078390
F1000Res. 2017 May 15;6:675
pubmed: 28620464
Cell. 2012 Dec 7;151(6):1256-69
pubmed: 23217709
Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596
pubmed: 33376223
Neurosci Lett. 2019 Apr 1;697:17-23
pubmed: 29548988
EMBO J. 2016 Oct 17;35(20):2238-2262
pubmed: 27613546
Nature. 1998 Apr 9;392(6676):605-8
pubmed: 9560156
Curr Opin Genet Dev. 2017 Jun;44:38-46
pubmed: 28213157
Mol Biol Cell. 2004 Mar;15(3):1101-11
pubmed: 14699058
Curr Opin Neurobiol. 2019 Aug;57:9-16
pubmed: 30677713
J Neurosci. 2010 Mar 3;30(9):3157-66
pubmed: 20203175
Neuron. 2020 Mar 18;105(6):961-973
pubmed: 32191859
Nat Commun. 2020 Jun 12;11(1):2993
pubmed: 32532970
Bioessays. 2008 Nov;30(11-12):1075-83
pubmed: 18937340
J Biosci. 2006 Mar;31(1):137-55
pubmed: 16595883
Dev Cell. 2019 Apr 22;49(2):251-266.e8
pubmed: 30880001
J Biol Chem. 2010 Feb 5;285(6):3840-3849
pubmed: 19996097
J Biol Chem. 2018 Mar 23;293(12):4566-4574
pubmed: 29352104
J Cell Biol. 2021 Jul 5;220(7):
pubmed: 34014261
Cell. 2006 Nov 17;127(4):831-46
pubmed: 17110340
Autophagy. 2018;14(11):1898-1910
pubmed: 29989488
J Cell Biol. 2021 Aug 2;220(8):
pubmed: 34028500
J Cell Biol. 2015 May 11;209(3):377-86
pubmed: 25940348
Autophagy. 2020 Sep;16(9):1732-1733
pubmed: 32718208
Autophagy. 2014 Apr;10(4):694-6
pubmed: 24447917
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17071-6
pubmed: 24067654
Curr Opin Neurobiol. 2018 Feb;48:113-121
pubmed: 29274917
Dev Cell. 2016 Jul 25;38(2):171-85
pubmed: 27396362
Biol Cell. 2012 Apr;104(4):213-28
pubmed: 22188132
Cell Rep. 2020 Jun 30;31(13):107837
pubmed: 32610138
J Neurosci. 2011 Jul 13;31(28):10189-200
pubmed: 21752995
Neuron. 2017 Mar 8;93(5):1015-1034
pubmed: 28279350
Brain Struct Funct. 2018 Sep;223(7):3423-3445
pubmed: 29915867
J Cell Biol. 2014 Nov 24;207(4):453-62
pubmed: 25422373
EMBO J. 2018 Sep 14;37(18):
pubmed: 30065071
Front Neuroanat. 2020 Nov 19;14:592797
pubmed: 33328904
Nat Commun. 2018 Oct 12;9(1):4230
pubmed: 30315172
Neuron. 2003 Nov 13;40(4):733-48
pubmed: 14622578
J Neural Transm (Vienna). 2004 Oct;111(10-11):1209-18
pubmed: 15480834
J Cell Sci. 2016 Oct 15;129(20):3781-3791
pubmed: 27587839
Curr Opin Neurobiol. 2000 Jun;10(3):321-7
pubmed: 10851173
Elife. 2015 Feb 02;4:e05597
pubmed: 25643395
EMBO Rep. 2013 May;14(5):450-7
pubmed: 23478338
Autophagy. 2018;14(8):1475-1477
pubmed: 29940791
Nat Commun. 2020 Mar 9;11(1):1266
pubmed: 32152276
Nature. 2020 Feb;578(7794):301-305
pubmed: 32025038
Nat Commun. 2019 Nov 29;10(1):5448
pubmed: 31784514
Cell Rep. 2021 Apr 13;35(2):109006
pubmed: 33852853
J Cell Sci. 2016 Dec 1;129(23):4424-4435
pubmed: 27793976
Genome Res. 2009 Oct;19(10):1905-11
pubmed: 19549727
Nature. 2015 Jun 18;522(7556):354-8
pubmed: 26040720
Mol Cell. 2015 Jul 16;59(2):270-84
pubmed: 26118642
J Cell Biol. 2017 Feb;216(2):441-461
pubmed: 28100687
Mol Cell. 2012 Mar 9;45(5):629-41
pubmed: 22342342
Neuron. 2014 Jun 4;82(5):981-8
pubmed: 24908483
Rev Neurosci. 2014;25(4):543-57
pubmed: 24651020
J Biol Chem. 2009 Jan 23;284(4):2363-73
pubmed: 19017649
Curr Opin Neurobiol. 2019 Aug;57:94-101
pubmed: 30784982
J Cell Biol. 2012 Feb 20;196(4):483-96
pubmed: 22351926
Cells. 2019 Jan 09;8(1):
pubmed: 30634508
Autophagy. 2011 Jul;7(7):689-95
pubmed: 21460635
Med Mol Morphol. 2016 Mar;49(1):28-33
pubmed: 26242203
Nat Rev Neurosci. 2011 Mar;12(3):127-38
pubmed: 21304549
Elife. 2020 Mar 03;9:
pubmed: 32125271
Neuron. 2011 Nov 17;72(4):587-601
pubmed: 22099461
Neuron. 2018 Jun 27;98(6):1184-1197.e6
pubmed: 29953872
Neuron. 2005 Jan 20;45(2):279-91
pubmed: 15664179
Neuron. 2016 Nov 23;92(4):829-844
pubmed: 27720484
Dev Neurobiol. 2016 Mar;76(3):252-61
pubmed: 26058471
Mol Cell. 2020 Dec 3;80(5):764-778.e7
pubmed: 33207182
Front Cell Neurosci. 2020 Dec 17;14:602116
pubmed: 33390907
Autophagy. 2019 Oct;15(10):1840-1842
pubmed: 31291815
Nat Commun. 2017 Apr 07;8:14819
pubmed: 28387218
Nat Commun. 2016 Jan 12;7:10338
pubmed: 26753620
Autophagy. 2011 Jan;7(1):61-73
pubmed: 21068542
Neuron. 2016 May 18;90(4):675-91
pubmed: 27196972
Mol Cell Neurosci. 2014 Mar;59:106-18
pubmed: 24534009
EMBO Rep. 2015 Jun;16(6):709-18
pubmed: 25925668
Arch Pharm Res. 2019 May;42(5):407-415
pubmed: 30937842
Autophagy. 2017 May 4;13(5):971-972
pubmed: 28282269
Nat Commun. 2020 Mar 24;11(1):1535
pubmed: 32210230
Mol Cell Neurosci. 2003 Jun;23(2):279-91
pubmed: 12812759
J Neurosci. 2015 Apr 15;35(15):6179-94
pubmed: 25878289
Cell Rep. 2014 Oct 9;9(1):206-218
pubmed: 25284778
Curr Biol. 2018 Apr 2;28(7):1027-1038.e4
pubmed: 29551411