A glimpse into the future of systemic lupus erythematosus.
B cell depletion
calcineurin inhibition
classification criteria
costimulation blockade
diagnosis
interferon receptor blockade
lupus nephritis
quality of life
recommendations
systemic lupus erythematosus
therapy
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
12
2021
accepted:
23
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
This viewpoint article on a forecast of clinically meaningful changes in the management of systemic lupus erythematosus (SLE) in the next 10 years is based on a review of the current state of the art. The groundwork has been laid by a robust series of classification criteria and treatment recommendations that have all been published since 2019. Building on this strong foundation, SLE management predictably will take significant steps forward. Assessment for lupus arthritis will presumably include musculoskeletal sonography. Large-scale polyomics studies are likely to unravel more of the central immune mechanisms of the disease. Biomarkers predictive of therapeutic success may enter the field; the type I interferon signature, as a companion for use of anifrolumab, an antibody against the common type I interferon receptor, is one serious candidate. Besides anifrolumab for nonrenal SLE and the new calcineurin inhibitor voclosporin in lupus nephritis, both of which are already approved in the United States and likely to become available in the European Union in 2022, several other approaches are in advanced clinical trials. These include advanced B cell depletion, inhibition of costimulation
Identifiants
pubmed: 35368371
doi: 10.1177/1759720X221086719
pii: 10.1177_1759720X221086719
pmc: PMC8972918
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X221086719Informations de copyright
© The Author(s), 2022.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: MA: consultant for AbbVie, AstraZeneca, GSK, Lilly, Pfizer, Roche, and UCB. MA-R: none. MC: consultant for UCB and GSK; grants form GSK and Pfizer. MEAR: grants from IMI2 grant with in-kind contribution from Sanofi, GSK, Pfizer, Janssen, Roche, Novartis, Takeda, and AstraZeneca. GPE: speaker and consultant for, and grants from, Pfizer, Janssen, GSK, Sandoz, and Sanofi. EMV: consultant for Novartis, AstraZeneca, Lilly, Aurinia, and Roche; grants from AstraZeneca and Sandoz. MDE: consultant for Aurinia, GSK, AstraZeneca, Lilly, and Biogen.
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