A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer.
Aging
Breast
Elderly
Glioblastoma
Lung
Neuroinflammation
Prostate
SSRI
Senescence
Journal
Brain, behavior, & immunity - health
ISSN: 2666-3546
Titre abrégé: Brain Behav Immun Health
Pays: United States
ID NLM: 101759062
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
12
12
2021
revised:
03
03
2022
accepted:
12
03
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Older adults ≥65 years of age represent the majority of new cancer diagnoses and are vulnerable to developing depression-like symptoms. Evaluation and management of depression in older cancer patients is underappreciated despite its high prevalence and impact on health-related quality of life. Although antidepressants are the primary pharmacologics used to treat depressive-like symptoms, the efficacy and overall benefit(s) are not well-characterized in older adult patients with cancer. The objective of this investigation was to review what is known about the efficacy of pharmacologic treatment for older adults with depression and cancer. PubMed (Medline) and EMBASE (Elsevier) databases were analyzed for relevant literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 1,919 unique studies were identified for title and abstract screening. Forty-eight publications were retrieved for full review. None of the identified studies evaluated the potential for benefit after pharmacological treatment among older adults with cancer and depression. Twenty-seven publications met all study criteria except for an analysis focused on older patients. We discovered a universal absence of literature with a relevance to pharmacologic antidepressant treatment effects in older adult patients with cancer. This included a lack of evaluation in patients with brain tumors who have an unusually high predilection for developing depression. Our findings suggest that new research is critically needed for understanding optimal clinical management strategies in older adults with cancer and depression who are treated with antidepressants.
Sections du résumé
Background
UNASSIGNED
Older adults ≥65 years of age represent the majority of new cancer diagnoses and are vulnerable to developing depression-like symptoms. Evaluation and management of depression in older cancer patients is underappreciated despite its high prevalence and impact on health-related quality of life. Although antidepressants are the primary pharmacologics used to treat depressive-like symptoms, the efficacy and overall benefit(s) are not well-characterized in older adult patients with cancer. The objective of this investigation was to review what is known about the efficacy of pharmacologic treatment for older adults with depression and cancer.
Methods
UNASSIGNED
PubMed (Medline) and EMBASE (Elsevier) databases were analyzed for relevant literature in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Results
UNASSIGNED
1,919 unique studies were identified for title and abstract screening. Forty-eight publications were retrieved for full review. None of the identified studies evaluated the potential for benefit after pharmacological treatment among older adults with cancer and depression. Twenty-seven publications met all study criteria except for an analysis focused on older patients.
Conclusion
UNASSIGNED
We discovered a universal absence of literature with a relevance to pharmacologic antidepressant treatment effects in older adult patients with cancer. This included a lack of evaluation in patients with brain tumors who have an unusually high predilection for developing depression. Our findings suggest that new research is critically needed for understanding optimal clinical management strategies in older adults with cancer and depression who are treated with antidepressants.
Identifiants
pubmed: 35368609
doi: 10.1016/j.bbih.2022.100449
pii: S2666-3546(22)00039-4
pmc: PMC8968450
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100449Subventions
Organisme : NINDS NIH HHS
ID : F32 NS073366
Pays : United States
Organisme : NINDS NIH HHS
ID : R00 NS082381
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009560
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS082381
Pays : United States
Organisme : NIA NIH HHS
ID : K02 AG068617
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA221747
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Am J Psychiatry. 1996 Mar;153(3):311-20
pubmed: 8610817
Clin Breast Cancer. 2022 Apr;22(3):e362-e373
pubmed: 34740542
J Clin Oncol. 2009 Jun 10;27(17):2758-65
pubmed: 19403886
Pharm Weekbl Sci. 1982 Oct 22;4(5):139-45
pubmed: 6128715
Breast Cancer Res Treat. 2001 Nov;70(1):1-10
pubmed: 11766999
Ann Phys Rehabil Med. 2016 Feb;59(1):42-57
pubmed: 26797170
Neurooncol Adv. 2021 Sep 04;3(1):vdab125
pubmed: 34647022
Arch Gerontol Geriatr. 2015 Jan-Feb;60(1):9-15
pubmed: 25266607
P T. 2015 Jan;40(1):36-40
pubmed: 25628505
Cochrane Database Syst Rev. 2020 Jul 17;7:CD006932
pubmed: 32678464
Cochrane Database Syst Rev. 2010 Mar 17;(3):CD006932
pubmed: 20238352
J Natl Cancer Inst Monogr. 2004;(32):105-11
pubmed: 15263050
Clin Pharmacokinet. 2016 Feb;55(2):249-55
pubmed: 26446141
N Engl J Med. 1999 Dec 30;341(27):2061-7
pubmed: 10615079
Neurol Int. 2021 Aug 05;13(3):387-401
pubmed: 34449705
BMC Pharmacol Toxicol. 2020 Mar 23;21(1):25
pubmed: 32293547
Palliat Support Care. 2003 Mar;1(1):71-7
pubmed: 16594290
Tumori. 2011 May-Jun;97(3):358-61
pubmed: 21789016
Biol Psychiatry. 2002 Aug 1;52(3):226-35
pubmed: 12182928
Neuropsychopharmacology. 2004 Dec;29(12):2285-99
pubmed: 15340391
Psychol Med. 2014 Apr;44(5):897-907
pubmed: 23778105
Ann Pharmacother. 2000 Nov;34(11):1302-12
pubmed: 11098346
J Clin Psychiatry. 2006 Feb;67(2):288-96
pubmed: 16566626
Lancet. 2016 Oct 8;388(10053):1545-1602
pubmed: 27733282
Int J Gynecol Cancer. 2011 Aug;21(6):1143-9
pubmed: 21792017
J Natl Cancer Inst Monogr. 2004;(32):57-71
pubmed: 15263042
Trans Am Clin Climatol Assoc. 2006;117:147-55; discussion 155-6
pubmed: 18528470
Indian J Palliat Care. 2017 Oct-Dec;23(4):445-450
pubmed: 29123353
Ann Clin Psychiatry. 2012 Feb;24(1):91-109
pubmed: 22303525
Br J Clin Pharmacol. 1992 Sep;34(3):262-5
pubmed: 1389951
NCHS Data Brief. 2017 Aug;(283):1-8
pubmed: 29155679
Eur J Cancer. 2003 May;39(7):870-80
pubmed: 12706355
Clin Interv Aging. 2016 May 02;11:497-505
pubmed: 27194906
Biochem Biophys Res Commun. 2011 Sep 23;413(2):311-7
pubmed: 21889492
Am J Geriatr Psychiatry. 1993 Winter;1(1):21-29
pubmed: 28530942
Curr Opin Psychiatry. 2021 Sep 1;34(5):448-459
pubmed: 34224469
BMJ. 2021 Mar 29;372:n71
pubmed: 33782057
Diabetologia. 2004 Aug;47(Suppl 1):A1-A464
pubmed: 27770180
Clin Drug Investig. 2008;28(2):113-20
pubmed: 18211119
Br J Clin Pharmacol. 2000 Jun;49(6):539-47
pubmed: 10848717
Crit Rev Oncol Hematol. 2008 Feb;65(2):143-55
pubmed: 18068997
Prim Care. 2017 Sep;44(3):499-510
pubmed: 28797375
Am J Geriatr Psychiatry. 2008 Jul;16(7):558-67
pubmed: 18591576
Int J Psychiatry Med. 2013;46(4):375-86
pubmed: 24922988
J Affect Disord. 2009 Feb;113(1-2):127-32
pubmed: 18558439
JAMA. 1998 Jun 17;279(23):1877-82
pubmed: 9634258
Psychooncology. 2017 Oct;26(10):1484-1490
pubmed: 27195436
J Geriatr Oncol. 2019 Jan;10(1):60-67
pubmed: 29937422
Crit Rev Oncol Hematol. 2003 Nov;48(2):185-97
pubmed: 14607382
Acta Psychiatr Scand. 1996 Sep;94(3):205-10
pubmed: 8891089
Med Care. 1993 Mar;31(3):247-63
pubmed: 8450681
Br J Cancer. 2012 Mar 27;106(7):1353-60
pubmed: 22353805
Support Care Cancer. 2008 Jan;16(1):83-91
pubmed: 17874143
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
J Gerontol Soc Work. 2006;47(1-2):17-25
pubmed: 16901875
BMC Psychiatry. 2013 May 16;13:140
pubmed: 23679841
Aging (Albany NY). 2020 Oct 28;12(20):20095-20110
pubmed: 33113511
Oncol Rep. 2016 Aug;36(2):676-84
pubmed: 27278525
BMC Psychol. 2015 Mar 11;3(1):6
pubmed: 25815195
J Natl Cancer Inst. 1993 Mar 3;85(5):365-76
pubmed: 8433390
Am J Geriatr Psychiatry. 2005 Mar;13(3):195-201
pubmed: 15728750
J Natl Cancer Inst Monogr. 2004;(32):150-7
pubmed: 15263059
Indian J Psychiatry. 2017 Jan;59(Suppl 1):S34-S50
pubmed: 28216784
Pharmacol Res. 2016 May;107:398-406
pubmed: 27060675
Cochrane Database Syst Rev. 2013 May 31;(5):CD006932
pubmed: 23728663
Med Sci Monit. 2014 Jul 22;20:1267-73
pubmed: 25047152
Br J Psychiatry. 1982 Jul;141:45-9
pubmed: 7116071
Br J Psychiatry. 1996 Oct;169(4):440-3
pubmed: 8894194
Tumori. 2009 Jul-Aug;95(4):479-83
pubmed: 19856660
Breast Cancer Res Treat. 2008 Nov;112(1):197-201
pubmed: 18064563
Eur Neuropsychopharmacol. 2006 Dec;16(8):601-11
pubmed: 16769204
J Clin Oncol. 2003 Apr 1;21(7):1383-9
pubmed: 12663731
Eur J Cancer. 2011 Mar;47(5):702-12
pubmed: 21211961
BMC Cancer. 2011 Jun 30;11:283
pubmed: 21718478
Prim Care Companion J Clin Psychiatry. 2001 Feb;3(1):22-27
pubmed: 15014625
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Am J Clin Oncol. 2011 Aug;34(4):385-7
pubmed: 20859197
Br J Pharmacol. 2007 Jul;151(6):737-48
pubmed: 17471183
Neurooncol Pract. 2020 Apr 25;7(5):514-521
pubmed: 33014392
Oncol Nurs Forum. 1999 Apr;26(3):593-9
pubmed: 10214600
Am J Psychiatry. 2004 Dec;161(12):2163-77
pubmed: 15569884
Acta Psychiatr Scand. 1983 Jun;67(6):361-70
pubmed: 6880820
Cancer. 1995 Mar 1;75(5):1151-61
pubmed: 7850714
Drugs Context. 2015 Oct 08;4:212290
pubmed: 26576188
J Clin Oncol. 2014 May 20;32(15):1605-19
pubmed: 24733793
CA Cancer J Clin. 2019 Nov;69(6):452-467
pubmed: 31390062
J Affect Disord. 2018 Jan 15;226:326-331
pubmed: 29031182
J Psychiatr Res. 1993 Jul-Sep;27(3):259-73
pubmed: 8295158
Hum Psychopharmacol. 2011 Jun-Jul;26(4-5):291-9
pubmed: 21751250
BMJ. 2016 Oct 12;355:i4919
pubmed: 27733354
BMJ. 2018 Nov 28;363:k4922
pubmed: 30487197
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Oncotarget. 2017 Jan 10;8(2):2356-2360
pubmed: 27926528
Ann Oncol. 2018 Jan 1;29(1):101-111
pubmed: 29272358
BMC Cancer. 2021 Mar 8;21(1):248
pubmed: 33685410
CA Cancer J Clin. 2021 Jan;71(1):78-92
pubmed: 33002206
Clin Interv Aging. 2017 Apr 21;12:709-720
pubmed: 28461745
Neurotherapeutics. 2017 Jul;14(3):734-740
pubmed: 28585222
Epidemiol Psychiatr Sci. 2019 Mar 14;29:e24
pubmed: 30867082
J Clin Psychiatry. 2001;62 Suppl 16:5-9
pubmed: 11480882
Psychooncology. 2012 Aug;21(8):818-26
pubmed: 21544897
J Affect Disord. 2021 Dec 1;295:291-297
pubmed: 34482061
Psychooncology. 2011 Sep;20(9):943-52
pubmed: 20687194
Cancer J. 2005 Nov-Dec;11(6):437-41
pubmed: 16393477
Support Care Cancer. 2008 Nov;16(11):1291-8
pubmed: 18299900
J Cell Mol Med. 2018 Feb;22(2):1167-1178
pubmed: 29105282
Aging Med (Milton). 2019 Feb 14;2(1):42-49
pubmed: 31942511
Eur J Cancer. 2017 Feb;72:46-53
pubmed: 28024266
Chonnam Med J. 2018 May;54(2):101-112
pubmed: 29854675
Curr Drug Metab. 2011 Jul;12(6):570-7
pubmed: 21395523
J Clin Oncol. 1998 Apr;16(4):1594-600
pubmed: 9552071
BMC Psychiatry. 2015 Dec 17;15:315
pubmed: 26678837
Med Oncol. 2014 May;31(5):921
pubmed: 24668415
Mayo Clin Proc. 2000 Jul;75(7):711-21
pubmed: 10907387
Tumori. 2008 Jul-Aug;94(4):563-7
pubmed: 18822694
BMJ. 2019 Aug 28;366:l4898
pubmed: 31462531
J Support Oncol. 2003 Nov-Dec;1(4 Suppl 2):18-24
pubmed: 15346996
Psychother Psychosom. 2020;89(3):133-150
pubmed: 32289809
J Psychosoc Oncol. 2006;24(1):43-50
pubmed: 16803751
J Psychiatr Pract. 2004 Jul;10(4):239-48
pubmed: 15552546
Brain Behav Immun Health. 2020 Feb;2:
pubmed: 32190845
Surg Neurol. 2009 Mar;71(3):299-303, discussion 303
pubmed: 18786716
Br J Clin Pharmacol. 2004 Jan;57(1):6-14
pubmed: 14678335
Drugs. 1997 Apr;53(4):608-36
pubmed: 9098663
Psychosomatics. 2006 Jan-Feb;47(1):33-42
pubmed: 16384805
Lancet Neurol. 2011 Feb;10(2):123-30
pubmed: 21216670
Depress Res Treat. 2012;2012:676784
pubmed: 22970357
Pharmacology. 2011;88(5-6):333-9
pubmed: 22123153
J Affect Disord. 2001 May;64(2-3):203-16
pubmed: 11313087
PLoS One. 2018 Jun 29;13(6):e0199750
pubmed: 29958268
Health Aff (Millwood). 1995 Spring;14(1):276-86
pubmed: 7657215
Cochrane Database Syst Rev. 2015 Jun 01;(6):CD011006
pubmed: 26029972
Eur Rev Med Pharmacol Sci. 2017 Nov;21(21):4966-4974
pubmed: 29164561
Psychiatry Res. 2012 Jun 30;198(1):62-7
pubmed: 22445070
Anesthesiol Res Pract. 2020 Apr 1;2020:5798285
pubmed: 32308676
Oncotarget. 2015 Mar 10;6(7):5088-101
pubmed: 25671301
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Mar 30;36(2):318-23
pubmed: 22142651
Clin Neurol Neurosurg. 2016 Jan;140:6-10
pubmed: 26615463
CNS Spectr. 2005 Sep;10(9):732-47
pubmed: 16142213
Eur Neuropsychopharmacol. 2014 Apr;24(4):491-8
pubmed: 24503279
Neuropsychopharmacology. 2013 Sep;38(10):1921-8
pubmed: 23575741
J Affect Disord. 1998 Dec;51(3):237-54
pubmed: 10333980
Clin Cancer Res. 2020 Oct 1;26(19):5232-5245
pubmed: 32546647
Cochrane Database Syst Rev. 2018 Apr 23;4:CD011006
pubmed: 29683474
Lung Cancer. 2013 Jan;79(1):46-53
pubmed: 23102652
Am J Hosp Palliat Care. 2001 Nov-Dec;18(6):403-7
pubmed: 11712722
Clin Biochem Rev. 2006 Feb;27(1):17-25
pubmed: 16886044
Lancet. 2005 Jun 4-10;365(9475):1961-70
pubmed: 15936426
Pharmacy (Basel). 2018 May 14;6(2):
pubmed: 29757930
J Affect Disord. 2012 Dec 10;141(2-3):103-15
pubmed: 22480823
Dialogues Clin Neurosci. 2006;8(2):207-15
pubmed: 16889106
Curr Opin Behav Sci. 2019 Aug;28:44-50
pubmed: 31049368
Oncology (Williston Park). 1999 May;13(5A):113-47
pubmed: 10370925
Psychooncology. 1998 Jul-Aug;7(4):291-300
pubmed: 9741068
Int J Environ Res Public Health. 2019 Jul 16;16(14):
pubmed: 31315203
Psychooncology. 2015 Sep;24(9):987-1001
pubmed: 26268799
J Am Geriatr Soc. 2015 May;63(5):1002-9
pubmed: 25945410
Perspect Clin Res. 2015 Oct-Dec;6(4):184-9
pubmed: 26623388
J Palliat Med. 2014 Feb;17(2):167-75
pubmed: 24432818
Br J Cancer. 2006 Feb 13;94(3):372-90
pubmed: 16465173
Support Care Cancer. 2012 Feb;20(2):375-84
pubmed: 21404089
Oncotarget. 2017 Feb 25;8(34):57543-57551
pubmed: 28915694
P T. 2012 Jan;37(1):28-31
pubmed: 22346333
J Clin Oncol. 2004 Nov 15;22(22):4626-31
pubmed: 15542812
J Gen Intern Med. 2001 Sep;16(9):606-13
pubmed: 11556941
Psychopharmacol Bull. 2016 Mar 1;46(1):77-104
pubmed: 27738376
North Clin Istanb. 2015 Apr 24;2(1):73-80
pubmed: 28058345
J Clin Oncol. 2015 Nov 10;33(32):3826-33
pubmed: 26195697
Postgrad Med. 2004 Jun;115(6):26-8, 37-42
pubmed: 15216572
Acta Psychiatr Scand Suppl. 1985;320:85-92
pubmed: 3901675
Cleve Clin J Med. 2010 Dec;77(12):859-82
pubmed: 21147941
Clin Neurol Neurosurg. 2018 Sep;172:8-19
pubmed: 29957299
Neurooncol Pract. 2015 Dec;2(4):185-191
pubmed: 31386049
J Clin Oncol. 2005 Apr 1;23(10):2201-7
pubmed: 15800312
Lancet Neurol. 2019 Apr;18(4):376-393
pubmed: 30797715
Support Care Cancer. 2007 May;15(5):539-46
pubmed: 17406919
Cancer Treat Rev. 2014 Apr;40(3):349-55
pubmed: 24084477
J Clin Psychiatry. 2004 Apr;65(4):515-20
pubmed: 15119914
Support Care Cancer. 2007 Feb;15(2):123-36
pubmed: 17058100
BMC Geriatr. 2020 Aug 27;20(1):310
pubmed: 32854659