The Imbalance of Mitochondrial Homeostasis of Peripheral Blood-Derived Macrophages Mediated by MAFLD May Impair the Walking Ability of Elderly Patients with Osteopenia.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
12
2021
revised:
28
02
2022
accepted:
04
03
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
6
4
2022
Statut:
epublish
Résumé
Many Asian cohort studies have shown that nonalcoholic fatty liver disease (NAFLD), now renamed as metabolic dysfunction-associated fatty liver disease (MAFLD), increases the risk of osteoporosis, yet the effect of MAFLD on elderly patients with osteopenia (OPe) has not been reported. This study aimed to explore the influence of MAFLD on the function of macrophages in patients with OPe. A total of 107 elderly OPe patients with or without MAFLD who visited the Huadong Hospital Affiliated to Fudan University (Shanghai, China) between January 1st, 2021, and September 30th, 2021, were evaluated for an interviewer-assisted questionnaire, as well as clinical and biological assessments. Comparing two groups of elderly patients with the same bone mass level, we found that the six-minute walking distance ( To conclude, our data revealed that MAFLD itself may aggravate the inflammatory state in elderly OPe people due to mitochondrial homeostasis imbalance of peripheral blood macrophages. Damaged monocyte-macrophages might trigger attenuation of the walking ability of OPe patients.
Identifiants
pubmed: 35368864
doi: 10.1155/2022/5210870
pmc: PMC8970807
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5210870Informations de copyright
Copyright © 2022 Xiaojun Wang et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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