Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier.
anti-inflammation
anti-tumor
antioxidant
intestinal barrier
resveratrol
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
01
2022
accepted:
07
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
The integrity of intestinal barrier determines intestinal homeostasis, which could be affected by various factors, like physical, chemical, and biological stimuli. Therefore, it is of considerable interest and importance to maintain intestinal barrier function. Fortunately, many plant polyphenols, including resveratrol, could affect the health of intestinal barrier. Resveratrol has many biological functions, such as antioxidant, anti-inflammation, anti-tumor, and anti-cardiovascular diseases. Accumulating studies have shown that resveratrol affects intestinal tight junction, microbial composition, and inflammation. In this review, we summarize the effects of resveratrol on intestinal barriers as well as the potential mechanisms (e.g., inhibiting the growth of pathogenic bacteria and fungi, regulating the expression of tight junction proteins, and increasing anti-inflammatory T cells while reducing pro-inflammatory T cells), and highlight the applications of resveratrol in ameliorating various intestinal diseases.
Identifiants
pubmed: 35369090
doi: 10.3389/fnut.2022.848400
pmc: PMC8966610
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
848400Informations de copyright
Copyright © 2022 Wang, Hong, Wu, Li, Xia, Liang, He, Xiao and Tang.
Déclaration de conflit d'intérêts
WT and SL were employed by Sichuan Animtech Feed Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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