Transcranial Doppler sonography and the effect of haematopoietic stem cell transplantation in sickle cell disease.
Haematopoietic stem cell transplantation
Sickle cell disease
Stroke
Transcranial Doppler
Journal
Neurological research and practice
ISSN: 2524-3489
Titre abrégé: Neurol Res Pract
Pays: England
ID NLM: 101767802
Informations de publication
Date de publication:
04 Apr 2022
04 Apr 2022
Historique:
received:
11
10
2021
accepted:
18
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Sickle cell disease (SCD) is one of the most prevalent monogenetic diseases worldwide and one of the most serious complications is stroke. Transcranial Doppler (TCD) demonstrated to be highly predictive for an imminent stroke by measuring blood flow velocities in the basal cerebral arteries. Currently, the only curative therapy for SCD is hematopoietic stem cell transplantation (HSCT). The aim of this study is to verify the correlation between blood flow velocities and stroke including the effect of HSCT. In our retrospective single-center study a total of 26 sickle cell patients (HbSS, HbSß In our study, ten patients had normal blood flow velocities before HSCT (six HbSS and four HbSß In our study, none of the patients with stroke displayed abnormal blood flow velocities in TCD. Yet, HSCT at this stage of the disease still had a positive effect on TAMMV. Further studies are needed whether this effect converts into reduced stroke risk at all or only selected SCD patients undergoing HSCT.
Sections du résumé
BACKGROUND
BACKGROUND
Sickle cell disease (SCD) is one of the most prevalent monogenetic diseases worldwide and one of the most serious complications is stroke. Transcranial Doppler (TCD) demonstrated to be highly predictive for an imminent stroke by measuring blood flow velocities in the basal cerebral arteries. Currently, the only curative therapy for SCD is hematopoietic stem cell transplantation (HSCT). The aim of this study is to verify the correlation between blood flow velocities and stroke including the effect of HSCT.
METHODS
METHODS
In our retrospective single-center study a total of 26 sickle cell patients (HbSS, HbSß
RESULTS
RESULTS
In our study, ten patients had normal blood flow velocities before HSCT (six HbSS and four HbSß
CONCLUSION
CONCLUSIONS
In our study, none of the patients with stroke displayed abnormal blood flow velocities in TCD. Yet, HSCT at this stage of the disease still had a positive effect on TAMMV. Further studies are needed whether this effect converts into reduced stroke risk at all or only selected SCD patients undergoing HSCT.
Identifiants
pubmed: 35369878
doi: 10.1186/s42466-022-00175-y
pii: 10.1186/s42466-022-00175-y
pmc: PMC8978343
doi:
Types de publication
Journal Article
Langues
eng
Pagination
12Informations de copyright
© 2022. The Author(s).
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