Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-Versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome.
acute respiratory distress syndrome (ARDS)
cellular therapy
coronavirus-induced disease 2019 (COVID-19)
graft-versus host disease (GvHD)
hematopoietic engraftment
immunomodulation
mesenchymal stromal cells (MSCs)
regeneration
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
20
12
2021
accepted:
17
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Mesenchymal stromal cells (MSCs) possess profound immunomodulatory and regenerative properties that are of clinical use in numerous clinical indications with unmet medical need. Common sources of MSCs include among others, bone marrow (BM), fat, umbilical cord, and placenta-derived decidua stromal cells (DSCs). We here summarize our more than 20-years of scientific experience in the clinical use of MSCs and DSCs in different clinical settings. BM-MSCs were first explored to enhance the engraftment of autografts in hematopoietic cell transplantation (HCT) and osteogenesis imperfecta around 30 years ago. In 2004, our group reported the first anti-inflammatory use of BM-MSCs in a child with grade IV acute graft-versus-host disease (GvHD). Subsequent studies have shown that MSCs appear to be more effective in acute than chronic GvHD. Today BM-MSC-therapy is registered for acute GvHD in Japan and for GvHD in children in Canada and New Zeeland. MSCs first home to the lung following intravenous injection and exert strong local and systemic immunomodulatory effects on the host immune system. Thus, they were studied for ameliorating the cytokine storm in acute respiratory distress syndrome (ARDS). Both, MSCs and DSCs were used to treat SARS-CoV-2 coronavirus-induced disease 2019 (COVID-19)-induced ARDS. In addition, they were also used for other novel indications, such as pneumomediastinum, colon perforation, and radiculomyelopathy. MSC and DSCs trigger coagulation and were thus explored to stop hemorrhages. DSCs appear to be more effective for acute GvHD, ARDS, and hemorrhages, but randomized studies are needed to prove superiority. Stromal cell infusion is safe, well tolerated, and only gives rise to a slight fever in a limited number of patients, but no major side effects have been reported in multiple safety studies and metaanalysis. In this review we summarize current evidence from
Identifiants
pubmed: 35371003
doi: 10.3389/fimmu.2022.839844
pmc: PMC8973075
doi:
Types de publication
Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
839844Informations de copyright
Copyright © 2022 Ringdén, Moll, Gustafsson and Sadeghi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Lancet Respir Med. 2015 Apr;3(4):e12
pubmed: 25890656
F1000Res. 2021 Mar 22;10:228
pubmed: 35350705
Biol Blood Marrow Transplant. 2020 May;26(5):855-864
pubmed: 32044400
Cells. 2019 Dec 05;8(12):
pubmed: 31817480
Pediatrics. 2012 Jun;129(6):e1612-5
pubmed: 22566416
Cochrane Database Syst Rev. 2019 Jan 30;1:CD009768
pubmed: 30697701
Stem Cells. 2012 Jul;30(7):1575-8
pubmed: 22553154
Transplantation. 1968 Mar;6(2):230-47
pubmed: 5654088
Clin Transl Med. 2021 Feb;11(2):e297
pubmed: 33634996
Lancet. 2021 Aug 14;398(10300):622-637
pubmed: 34217425
Blood. 2012 Oct 25;120(17):3436-43
pubmed: 22966167
Trends Mol Med. 2019 Feb;25(2):149-163
pubmed: 30711482
Stem Cells Dev. 2015 Jun 15;24(12):1471-82
pubmed: 25658253
Stem Cells Transl Med. 2020 Jan;9(1):17-27
pubmed: 31804767
Nat Med. 2013 Jan;19(1):35-42
pubmed: 23296015
Lancet Haematol. 2016 Jan;3(1):e45-52
pubmed: 26765648
Bone Marrow Transplant. 2002 Aug;30(4):215-22
pubmed: 12203137
Ann Hematol. 2019 Feb;98(2):473-479
pubmed: 30341538
J Intern Med. 2007 Nov;262(5):509-25
pubmed: 17949362
Signal Transduct Target Ther. 2021 Feb 10;6(1):58
pubmed: 33568628
Leukemia. 2007 Aug;21(8):1733-8
pubmed: 17541394
Cytotherapy. 2015 Dec;17(12):1732-45
pubmed: 26481415
N Engl J Med. 2020 May 7;382(19):1800-1810
pubmed: 32320566
Stem Cells Dev. 2015 Jan 15;24(2):253-63
pubmed: 25162829
J Immunol. 2007 Sep 1;179(5):2824-31
pubmed: 17709496
EClinicalMedicine. 2020 Jan 17;19:100249
pubmed: 31989101
Trends Immunol. 2007 Apr;28(4):184-92
pubmed: 17336159
Bone Marrow Transplant. 2011 Feb;46(2):200-7
pubmed: 20400983
Bone Marrow Transplant. 2014 Jun;49(6):737-43
pubmed: 24464141
J Immunol. 2010 Mar 1;184(5):2321-8
pubmed: 20130212
Best Pract Res Clin Haematol. 2011 Mar;24(1):65-72
pubmed: 21396594
Blood. 2010 Nov 11;116(19):3770-9
pubmed: 20644118
J Clin Oncol. 2000 Jan;18(2):307-16
pubmed: 10637244
Leukemia. 2008 Mar;22(3):593-9
pubmed: 18185520
Bone Marrow Transplant. 2017 Apr;52(4):606-608
pubmed: 27941780
Science. 1997 Apr 4;276(5309):71-4
pubmed: 9082988
Clin Exp Immunol. 2012 Mar;167(3):543-55
pubmed: 22288598
Lancet Respir Med. 2019 Apr;7(4):e14
pubmed: 30926051
Sci Rep. 2019 Dec 2;9(1):18078
pubmed: 31792313
J Thorac Dis. 2019 May;11(Suppl 9):S1329-S1332
pubmed: 31245124
Biol Blood Marrow Transplant. 2005 May;11(5):389-98
pubmed: 15846293
J Pediatr Hematol Oncol. 2019 Jan;41(1):42-46
pubmed: 30113355
Biol Blood Marrow Transplant. 2017 Jul;23(7):1122-1127
pubmed: 28344057
J Intensive Care Med. 2021 Jul;36(7):783-792
pubmed: 32274961
Elife. 2016 Nov 17;5:
pubmed: 27870924
Cytotherapy. 2015 Feb;17(2):186-98
pubmed: 25593077
J Clin Oncol. 2016 Aug 20;34(24):2843-50
pubmed: 27400949
Haematologica. 2005 Apr;90(4):516-25
pubmed: 15820948
Biol Blood Marrow Transplant. 2020 May;26(5):835-844
pubmed: 31505228
Stem Cell Res Ther. 2020 Feb 18;11(1):64
pubmed: 32070420
Leukemia. 2014 Apr;28(4):970-3
pubmed: 24445866
Exp Cell Res. 2005 Apr 15;305(1):33-41
pubmed: 15777785
Cell Stem Cell. 2012 May 4;10(5):544-55
pubmed: 22542159
Leukemia. 2007 Nov;21(11):2271-6
pubmed: 17611560
Stem Cell Res Ther. 2021 Jan 29;12(1):91
pubmed: 33514427
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
Cells. 2019 Sep 27;8(10):
pubmed: 31569696
Respir Res. 2014 Apr 04;15:39
pubmed: 24708472
Haematologica. 2011 Jul;96(7):1072-6
pubmed: 21393326
Front Immunol. 2019 Nov 08;10:2474
pubmed: 31781089
Annu Rev Pathol. 2011;6:147-63
pubmed: 20936936
Bone Marrow Transplant. 2009 Mar;43(6):447-54
pubmed: 18955980
Lancet. 2004 May 1;363(9419):1439-41
pubmed: 15121408
Stem Cells. 2012 Jul;30(7):1565-74
pubmed: 22522999
J Orthop Res. 1991 Sep;9(5):641-50
pubmed: 1870029
Stem Cells Transl Med. 2020 Apr;9(4):491-498
pubmed: 31903737
Lancet. 2008 May 10;371(9624):1579-86
pubmed: 18468541
Lancet Respir Med. 2015 Jan;3(1):24-32
pubmed: 25529339
Bone Marrow Transplant. 2021 Oct;56(10):2355-2366
pubmed: 33976381
Blood. 2007 Oct 1;110(7):2764-7
pubmed: 17638847
Blood. 2001 Mar 1;97(5):1227-31
pubmed: 11222364
Stem Cells Dev. 2013 Oct 1;22(19):2596-605
pubmed: 23701127
Bone Marrow Transplant. 2010 Dec;45(12):1732-40
pubmed: 20818445
Br J Haematol. 2013 Nov;163(4):501-9
pubmed: 23992039
Stem Cells. 2021 Sep;39(9):1145-1154
pubmed: 33786935
Eur J Immunol. 2005 May;35(5):1482-90
pubmed: 15827960
Nat Biotechnol. 2014 Mar;32(3):252-60
pubmed: 24561556
Exp Hematol. 2002 Jan;30(1):42-8
pubmed: 11823036
J Blood Med. 2021 Nov 09;12:951-964
pubmed: 34785969
J Thorac Cardiovasc Surg. 2004 May;127(5):1293-300
pubmed: 15115985
Nature. 2010 Nov 25;468(7323):485
pubmed: 21107396
Science. 1999 Apr 2;284(5411):143-7
pubmed: 10102814
Stem Cells. 2014 Sep;32(9):2430-42
pubmed: 24805247
Blood. 2012 Aug 30;120(9):1933-41
pubmed: 22829629
Int Arch Med. 2011 Aug 15;4(1):27
pubmed: 21843360
Clin Transplant. 2007 Sep-Oct;21(5):659-67
pubmed: 17845642
Biol Blood Marrow Transplant. 2010 Sep;16(9):1293-301
pubmed: 20350611
Stem Cells. 2008 Feb;26(2):300-11
pubmed: 17975221
Diabetes. 2013 Dec;62(12):4266-9
pubmed: 24043757
Biol Blood Marrow Transplant. 2010 Jun;16(6):838-47
pubmed: 20109568
Bone Marrow Transplant. 2011 Aug;46(8):1158-60
pubmed: 21076475
Br J Haematol. 2020 May;189(4):593-596
pubmed: 32037526
Trends Immunol. 2010 Jan;31(1):32-8
pubmed: 19836998
N Engl J Med. 2005 Oct 20;353(16):1685-93
pubmed: 16236739
Cells Tissues Organs. 2001;169(1):12-20
pubmed: 11340257
Stem Cells Transl Med. 2018 Apr;7(4):325-331
pubmed: 29533533
Blood. 2005 Feb 15;105(4):1815-22
pubmed: 15494428
J Pediatr Urol. 2018 Oct;14(5):366-373
pubmed: 29776868
Biomaterials. 2016 Sep;102:209-19
pubmed: 27343468
Front Immunol. 2019 Nov 19;10:2685
pubmed: 31803191
Int J Hematol. 2020 Apr;111(4):591-594
pubmed: 31853810
Front Immunol. 2020 May 19;11:1091
pubmed: 32574263
Transplantation. 2006 May 27;81(10):1390-7
pubmed: 16732175
Pediatr Transplant. 2009 Jun;13(4):499-502
pubmed: 18673358
Adv Exp Med Biol. 2016;951:77-98
pubmed: 27837556
Stem Cells Dev. 2015 Oct 1;24(19):2269-79
pubmed: 26192403
PLoS One. 2015 Aug 31;10(8):e0136991
pubmed: 26323092
Bone Marrow Transplant. 2017 Jun;52(6):859-862
pubmed: 28287644
Bone Marrow Transplant. 2017 May;52(5):704-710
pubmed: 28067873
Sci Adv. 2020 Jul 22;6(30):eaba6884
pubmed: 32832666
Stem Cells Transl Med. 2018 Oct;7(10):731-739
pubmed: 30070065
Blood. 2005 Dec 15;106(13):4057-65
pubmed: 16118325
Bone Marrow Transplant. 2021 Nov;56(11):2869-2870
pubmed: 34471240
Lancet Respir Med. 2019 Feb;7(2):154-162
pubmed: 30455077
Nat Rev Immunol. 2009 Aug;9(8):581-93
pubmed: 19498381
NPJ Regen Med. 2019 Dec 2;4:22
pubmed: 31815001
Tissue Eng Part B Rev. 2012 Apr;18(2):101-15
pubmed: 21995703
Transplantation. 2009 May 15;87(9 Suppl):S62-6
pubmed: 19424010
Cell Transplant. 2006;15(8-9):711-21
pubmed: 17269442
Nat Med. 2009 Jan;15(1):42-9
pubmed: 19098906
Haematologica. 2007 Sep;92(9):1208-15
pubmed: 17666368
Stem Cell Res. 2011 Jul;7(1):66-74
pubmed: 21546330
Biol Blood Marrow Transplant. 2019 Oct;25(10):1965-1969
pubmed: 31173898
Front Med (Lausanne). 2021 Oct 26;8:739987
pubmed: 34765617
Transplantation. 2003 Feb 15;75(3):389-97
pubmed: 12589164
Exp Hematol. 2003 Oct;31(10):890-6
pubmed: 14550804
Nat Med. 1999 Mar;5(3):309-13
pubmed: 10086387
Haematologica. 2016 Aug;101(8):985-94
pubmed: 27175026
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8932-7
pubmed: 12084934
Stem Cells Transl Med. 2021 Feb;10(2):291-302
pubmed: 32978903
Transplant Proc. 2017 Sep;49(7):1656-1658
pubmed: 28838459
Pediatr Transplant. 2020 Mar;24(2):e13618
pubmed: 31944495
Science. 1998 Aug 21;281(5380):1191-3
pubmed: 9712583
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
J Cell Mol Med. 2021 Nov;25(22):10554-10564
pubmed: 34632708
Blood Rev. 2021 Mar;46:100742
pubmed: 32854985
Sci Transl Med. 2017 Nov 15;9(416):
pubmed: 29141887
Bone Marrow Transplant. 2013 Aug;48(8):1040-5
pubmed: 23396407
Stem Cells. 2017 May;35(5):1437-1439
pubmed: 27758056
Acta Haematol. 2018;139(2):106-114
pubmed: 29408819
Front Immunol. 2021 Sep 29;12:749659
pubmed: 34659252
Blood. 2004 Jun 15;103(12):4619-21
pubmed: 15001472
Front Immunol. 2020 Oct 19;11:567210
pubmed: 33193339
Pediatr Transplant. 2007 Nov;11(7):814-7
pubmed: 17910665
Sci Rep. 2016 May 23;6:26463
pubmed: 27212469
Yonsei Med J. 2013 Sep;54(5):1293-6
pubmed: 23918585
Stem Cells Dev. 2016 Apr 15;25(8):586-97
pubmed: 26914168
Front Immunol. 2019 Jul 31;10:1645
pubmed: 31417542
PLoS One. 2012;7(10):e47559
pubmed: 23133515
Front Immunol. 2019 Jul 16;10:1627
pubmed: 31379832
Front Immunol. 2019 Apr 02;10:619
pubmed: 31001253
Front Immunol. 2020 Feb 18;11:243
pubmed: 32133010
Transplant Proc. 2019 Apr;51(3):880-889
pubmed: 30979480
PLoS One. 2011;6(7):e21703
pubmed: 21747949
PLoS One. 2014 Jan 13;9(1):e85040
pubmed: 24454787
Stem Cells Int. 2016;2016:1641402
pubmed: 26783400
Scand J Immunol. 2003 Jan;57(1):11-20
pubmed: 12542793
Biol Blood Marrow Transplant. 2011 Apr;17(4):534-41
pubmed: 20457269
Front Immunol. 2017 Jul 11;8:795
pubmed: 28744284