Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved.
Guillain-Barre syndrome
Zika virus
animal models
host factors
immune response
microcephaly
mitochondrial damage
neuroinflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
09
09
2021
accepted:
21
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
9
4
2022
Statut:
epublish
Résumé
Zika virus (ZIKV), despite being discovered six decades earlier, became a major health concern only after an epidemic in French Polynesia and an increase in the number of microcephaly cases in Brazil. Substantial evidence has been found to support the link between ZIKV and neurological complications in infants. The virus targets various cells in the brain, including radial glial cells, neural progenitor cells (NPCs), astrocytes, microglial and glioblastoma stem cells. It affects the brain cells by exploiting different mechanisms, mainly through apoptosis and cell cycle dysregulation. The modulation of host immune response and the inflammatory process has also been demonstrated to play a critical role in ZIKV induced neurological complications. In addition to that, different ZIKV strains have exhibited specific neurotropism and unique molecular mechanisms. This review provides a comprehensive and up-to-date overview of ZIKV-induced neuroimmunopathogenesis by dissecting its main target cells in the brain, and the underlying cellular and molecular mechanisms. We highlighted the roles of the different ZIKV host factors and how they exploit specific host factors through various mechanisms. Overall, it covers key components for understanding the crosstalk between ZIKV and the brain.
Identifiants
pubmed: 35371036
doi: 10.3389/fimmu.2022.773191
pmc: PMC8966389
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
773191Informations de copyright
Copyright © 2022 Komarasamy, Adnan, James and Balasubramaniam.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Cell Host Microbe. 2016 May 11;19(5):705-12
pubmed: 27066743
Cell Rep. 2016 Sep 6;16(10):2576-2592
pubmed: 27568284
Methods. 2005 Apr;35(4):373-81
pubmed: 15804610
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14408-14413
pubmed: 27911847
Biochem Soc Trans. 2020 Oct 30;48(5):2101-2115
pubmed: 32897294
Mem Inst Oswaldo Cruz. 2016 May;111(5):287-93
pubmed: 27143490
Genes Dev. 2017 May 1;31(9):849-861
pubmed: 28566536
Cell. 2018 Dec 13;175(7):1931-1945.e18
pubmed: 30550790
Cytokine Growth Factor Rev. 2016 Jun;29:71-81
pubmed: 27053489
PLoS One. 2012;7(12):e52937
pubmed: 23300826
Science. 2016 May 13;352(6287):816-8
pubmed: 27064148
Mol Cells. 2013 Jan;35(1):54-60
pubmed: 23212345
Cell Stem Cell. 2016 Dec 1;19(6):703-708
pubmed: 27912091
PLoS One. 2019 Feb 8;14(2):e0208543
pubmed: 30735502
Neurosurgery. 2018 May 1;82(5):E113-E114
pubmed: 29669124
Cell. 2014 Sep 25;159(1):200-214
pubmed: 25259927
N Engl J Med. 2016 Mar 10;374(10):951-8
pubmed: 26862926
J Virol. 2017 Jun 26;91(14):
pubmed: 28468880
Exp Mol Pathol. 2007 Dec;83(3):283-95
pubmed: 17945211
PLoS One. 2011;6(5):e19439
pubmed: 21637744
Nat Commun. 2018 Jan 29;9(1):414
pubmed: 29379028
Cell Host Microbe. 2016 Jun 8;19(6):882-90
pubmed: 27212660
Cell Stem Cell. 2017 Sep 7;21(3):349-358.e6
pubmed: 28826723
Front Neurol. 2020 Oct 15;11:570830
pubmed: 33178111
Sci Rep. 2018 Jan 8;8(1):1
pubmed: 29311619
Brain Res. 2005 Aug 30;1054(2):152-8
pubmed: 16054598
Clin Infect Dis. 2017 Apr 01;64(7):914-920
pubmed: 28362944
Cell Mol Life Sci. 2011 May;68(10):1719-36
pubmed: 21327915
Mol Cell Biol. 2006 Jun;26(11):4277-87
pubmed: 16705177
BMC Neurosci. 2018 Feb 20;19(1):5
pubmed: 29463209
Mol Cell Biochem. 2014 Oct;395(1-2):221-9
pubmed: 24990247
Placenta. 2013 Jul;34(7):613-8
pubmed: 23601695
Cell Death Dis. 2017 Oct 12;8(10):e3106
pubmed: 29022904
Mol Cell. 2006 Jul 21;23(2):152-3
pubmed: 16857581
J Virol. 2017 Nov 14;91(23):
pubmed: 28931684
Taiwan J Obstet Gynecol. 2017 Oct;56(5):585-592
pubmed: 29037541
Lancet. 2016 Apr 9;387(10027):1486-1488
pubmed: 26948432
PLoS Negl Trop Dis. 2019 Sep 17;13(9):e0007695
pubmed: 31527907
Eur J Neurosci. 2009 Oct;30(7):1209-18
pubmed: 19788570
J Cell Biol. 2003 Jan 20;160(2):189-200
pubmed: 12527753
Vaccines (Basel). 2021 Mar 19;9(3):
pubmed: 33808706
Cell Host Microbe. 2016 May 11;19(5):720-30
pubmed: 27066744
PLoS One. 2018 Oct 25;13(10):e0206093
pubmed: 30359409
J Infect Dis. 2019 Jan 1;219(1):26-30
pubmed: 30113672
Cell Mol Life Sci. 2017 Jan;74(2):213-229
pubmed: 27484406
Front Microbiol. 2019 Sep 18;10:2158
pubmed: 31620112
N Engl J Med. 2016 Oct 20;375(16):1598-1601
pubmed: 27579558
Development. 2017 Nov 15;144(22):4114-4124
pubmed: 28993398
Exp Mol Med. 2018 Apr 6;50(4):1-14
pubmed: 29622770
Cell Rep. 2016 Jun 14;15(11):2315-22
pubmed: 27268504
Cell Mol Life Sci. 2005 Mar;62(6):670-84
pubmed: 15770419
Virology. 2011 Mar 15;411(2):374-82
pubmed: 21295323
Mol Membr Biol. 2007 Jan-Feb;24(1):74-87
pubmed: 17453415
Nitric Oxide. 2010 Nov 1;23(3):153-65
pubmed: 20547235
Emerg Microbes Infect. 2019;8(1):426-437
pubmed: 30898036
Int J Biol Sci. 2018 Jun 8;14(9):1099-1108
pubmed: 29989100
Cell Stem Cell. 2020 Feb 6;26(2):187-204.e10
pubmed: 31956038
Nucleic Acids Res. 2018 Feb 16;46(3):1038-1051
pubmed: 29272451
Front Microbiol. 2018 Jun 05;9:1067
pubmed: 29922247
Prog Neurobiol. 1999 Apr;57(6):563-81
pubmed: 10221782
Cell Host Microbe. 2016 Jul 13;20(1):83-90
pubmed: 27247001
J Virol. 2015 Sep;89(17):8880-96
pubmed: 26085147
Cell Rep. 2019 Jan 22;26(4):906-920.e3
pubmed: 30673613
Nucleic Acids Res. 2016 Feb 29;44(4):1483-95
pubmed: 26773057
Nat Commun. 2020 Aug 4;11(1):3896
pubmed: 32753727
Lancet. 2016 Apr 9;387(10027):1531-1539
pubmed: 26948433
J Immunol. 2020 Dec 1;205(11):3107-3121
pubmed: 33127823
PLoS Pathog. 2020 May 1;16(5):e1008204
pubmed: 32357162
Mol Cell Proteomics. 2016 Jun;15(6):2055-75
pubmed: 27053602
PLoS Pathog. 2019 Jan 18;15(1):e1007507
pubmed: 30657788
PLoS Genet. 2016 Sep 12;12(9):e1006282
pubmed: 27618312
Nature. 2018 Sep;561(7722):253-257
pubmed: 30177828
Cell Res. 2016 Jun;26(6):645-54
pubmed: 27174054
Mol Cell Proteomics. 2018 Nov;17(11):2242-2255
pubmed: 30037810
Ann Neurol. 2016 Oct;80(4):566-80
pubmed: 27490360
Cell Adh Migr. 2015;9(3):167-74
pubmed: 25914082
Viruses. 2018 Nov 18;10(11):
pubmed: 30453684
J Virol. 2010 Apr;84(7):3528-41
pubmed: 20071566
Cell Stem Cell. 2016 May 5;18(5):587-90
pubmed: 26952870
RNA. 2013 Oct;19(10):1432-48
pubmed: 23962664
Front Microbiol. 2017 Dec 22;8:2557
pubmed: 29312238
Dev Dyn. 2018 Jan;247(1):47-53
pubmed: 28643345
Cell Stem Cell. 2016 Aug 4;19(2):258-265
pubmed: 27162029
Nat Commun. 2018 Apr 30;9(1):1731
pubmed: 29712910
Curr Med Chem. 2016;23(15):1496-512
pubmed: 27048336
Science. 2017 Nov 17;358(6365):933-936
pubmed: 28971967
PLoS Negl Trop Dis. 2018 Nov 12;12(11):e0006880
pubmed: 30418969
J Immunol. 2017 May 1;198(9):3526-3535
pubmed: 28330900
Emerg Microbes Infect. 2019;8(1):8-16
pubmed: 30866755
Front Microbiol. 2020 Dec 23;11:598203
pubmed: 33424801
Development. 2017 Mar 15;144(6):952-957
pubmed: 28292840
Front Genet. 2021 Mar 19;12:530028
pubmed: 33815457
Trends Cell Biol. 2011 Aug;21(8):470-80
pubmed: 21632253
Annu Rev Neurosci. 2009;32:149-84
pubmed: 19555289
Sci Rep. 2018 Feb 23;8(1):3541
pubmed: 29476066
Pediatrics. 2018 Feb;141(Suppl 2):S154-S160
pubmed: 29437048
Front Microbiol. 2020 Feb 20;11:214
pubmed: 32153526
PLoS Pathog. 2017 Feb 2;13(2):e1006164
pubmed: 28152048
Front Cell Neurosci. 2016 Sep 26;10:215
pubmed: 27725795
Biomed Res Int. 2014;2014:547986
pubmed: 25548773
Biochem Biophys Res Commun. 2018 Nov 30;506(3):463-470
pubmed: 30352685
Exp Cell Res. 2004 Aug 15;298(2):399-406
pubmed: 15265688
Sci Rep. 2018 Jan 24;8(1):1522
pubmed: 29367651
Nature. 2016 May 11;534(7606):267-71
pubmed: 27279226
Cell Discov. 2017 Mar 21;3:17006
pubmed: 28373913
Cell Stem Cell. 2016 May 5;18(5):591-6
pubmed: 27038591
Cell Host Microbe. 2016 Sep 14;20(3):342-356
pubmed: 27545046
Glia. 2008 Jun;56(8):903-16
pubmed: 18383342
Cell Stem Cell. 2016 Jul 7;19(1):120-6
pubmed: 27179424
Front Med (Lausanne). 2018 Mar 09;5:25
pubmed: 29594116
Cell Rep. 2016 Sep 20;16(12):3208-3218
pubmed: 27612415
N Engl J Med. 2016 May 19;374(20):1981-7
pubmed: 27074377
J Neurosci. 2003 Dec 17;23(37):11587-601
pubmed: 14684861
Development. 2010 Jun;137(11):1907-17
pubmed: 20460369
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23869-23878
pubmed: 32907937
PLoS Negl Trop Dis. 2017 Jan 9;11(1):e0005296
pubmed: 28068342
Transl Psychiatry. 2020 Jul 6;10(1):217
pubmed: 32632143
Cell Rep. 2017 Jan 10;18(2):324-333
pubmed: 28076778
Nucleic Acids Res. 2016 Oct 14;44(18):8610-8620
pubmed: 27580721
mBio. 2020 Aug 4;11(4):
pubmed: 32753493
Sci Rep. 2017 Nov 1;7(1):14883
pubmed: 29093521
Blood. 2010 Jul 15;116(2):297-305
pubmed: 20442363
Sci Signal. 2020 Jun 09;13(635):
pubmed: 32518143
Development. 2016 Nov 15;143(22):4127-4136
pubmed: 27729407
Stem Cell Reports. 2015 Sep 8;5(3):405-18
pubmed: 26321141
J Biochem. 2003 Sep;134(3):333-44
pubmed: 14561718
Nat Commun. 2017 Feb 21;8:14575
pubmed: 28220786
PLoS Negl Trop Dis. 2019 Aug 26;13(8):e0007622
pubmed: 31449532
Autoimmun Rev. 2016 Aug;15(8):801-8
pubmed: 27019049
Int J Mol Sci. 2019 Mar 06;20(5):
pubmed: 30845751
PLoS One. 2014 Jun 27;9(6):e101001
pubmed: 24971877
Sci Rep. 2021 Jan 11;11(1):393
pubmed: 33432092
Cell Rep. 2019 Jun 18;27(12):3618-3628.e5
pubmed: 31216479
Eukaryot Cell. 2014 Sep;13(9):1126-35
pubmed: 25038084
Viruses. 2018 Nov 17;10(11):
pubmed: 30453621
EMBO J. 2017 Jun 14;36(12):1653-1668
pubmed: 28473450
Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):7117-7122
pubmed: 29915057
Cells. 2020 Jan 08;9(1):
pubmed: 31936331
Cell Rep. 2019 May 21;27(8):2335-2353.e6
pubmed: 31116980
Sci Rep. 2020 Jan 27;10(1):1218
pubmed: 31988337
Nat Genet. 2005 Apr;37(4):353-5
pubmed: 15793586
Genes Dev. 2012 Mar 1;26(5):445-60
pubmed: 22357600
Cell. 2016 May 19;165(5):1081-1091
pubmed: 27180225
J Neurosci. 2006 Sep 20;26(38):9703-12
pubmed: 16988041
Dev Neurosci. 2004;26(5-6):380-7
pubmed: 15855767
J Neurosci. 2017 Feb 22;37(8):2161-2175
pubmed: 28123079
Cell Death Dis. 2016 Oct 27;7(10):e2440
pubmed: 27787521
PLoS Negl Trop Dis. 2012;6(2):e1477
pubmed: 22389730
Rev Neurosci. 2011;22(5):509-33
pubmed: 21861782