Feasibility and Efficacy of a Degradable Magnesium-Alloy GBR Membrane for Bone Augmentation in a Distal Bone-Defect Model in Beagle Dogs.
Journal
Bioinorganic chemistry and applications
ISSN: 1565-3633
Titre abrégé: Bioinorg Chem Appl
Pays: Egypt
ID NLM: 101200445
Informations de publication
Date de publication:
2022
2022
Historique:
received:
27
01
2022
accepted:
05
03
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
We explored the feasibility and efficacy of a degradable magnesium (Mg) alloy guided bone regeneration (GBR) in the treatment of bone defects after tooth extraction. A GBR membrane (MAR-Gide (MG)) was used to treat a mandibular second molar (M2M)-distal bone defect (DBD). In eight beagle dogs, bilateral mandibular second and fourth premolars were hemi-sected. The distal roots were removed to create a two-wall bony defect of dimension 5 mm × 5 mm × 5 mm to simulate M2M-DBD. Thirty-two bone defects were assigned randomly into four groups according to GBR membranes (MG and Bio-Gide (BG)) applied and the time of killing (3 months and 6 months after surgery). The osteogenesis of bone defects and MG degradation were analyzed using micro-CT, histology (staining, tartrate-resistant acid phosphatase), and inductively coupled plasma mass spectrometry. MG did not increase the prevalence of infection, wound dehiscence, or subcutaneous emphysema compared with those using BG. Trabecular volume/total volume at 3 months (63.71 ± 10.4%
Identifiants
pubmed: 35371192
doi: 10.1155/2022/4941635
pmc: PMC8967573
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4941635Informations de copyright
Copyright © 2022 Zi-Yu Yan et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding publication of this manuscript.
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