Multiple Myeloma and Renal Failure: Mechanisms, Diagnosis, and Management.
cast nephropathy
chemotherapy
dialysis
hematopoietic stem cell transplantation
high cut-off dialyzer
multiple myeloma
myeloma kidney
renal failure
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
accepted:
24
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Multiple myeloma (MM) is the second most common hematologic malignancy that involves monoclonal immunoglobulin (Ig)-producing plasma cells. Due to its multifaceted clinical manifestations and complications, it draws attention to various medical specialties like neurology, nephrology, orthopedics, cardiology, etc. Renal failure (RF) is one of the most common and most serious complications of MM that can be caused either by excess immunoglobulins that are nephrotoxic or some other causes like hypercalcemia, infection, etc. In this review article, we have discussed the pathogenesis of RF in MM, described the different diagnostic tools to diagnose RF in MM, and explained different treatment modalities to treat RF in MM, including certain general measures (i.e., hydration, withholding any nephrotoxic agents), renal replacement therapy, serum free light chain (SFLC) removal by plasma exchange and high cut-off dialyzer (HCO-HD), chemotherapy, hematopoietic stem cell transplantation (HSCT), and renal transplantation.
Identifiants
pubmed: 35371791
doi: 10.7759/cureus.22585
pmc: PMC8958144
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e22585Informations de copyright
Copyright © 2022, Kundu et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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