Arsenic trioxide for acute promyelocytic leukemia in a patient on chronic hemodialysis.
Acute promyelocytic leukemia
Arsenic trioxide
Hemodialysis
Journal
Leukemia research reports
ISSN: 2213-0489
Titre abrégé: Leuk Res Rep
Pays: England
ID NLM: 101608906
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
04
2021
revised:
10
01
2022
accepted:
22
03
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Acute promyelocytic leukemia (APL) is a rare acute leukemia generally considered curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Some patients have co-morbidities that may limit the use of these agents and therefore impact curability. Adverse effects of ATO include life-threatening electrocardiographic abnormalities. ATO and its metabolites are partially excreted in the urine, and it is unclear to what extent ATO pharmacokinetics are impacted by hemodialysis. We present a patient on chronic hemodialysis successfully treated with ATO and ATRA for newly diagnosed APL. Complete molecular remission was achieved after induction and several drug-related toxicities were managed.
Identifiants
pubmed: 35371914
doi: 10.1016/j.lrr.2022.100304
pii: S2213-0489(22)00016-4
pmc: PMC8968060
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100304Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
None
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