Gene Variation at Immunomodulatory and Cell Adhesion Molecules Loci Impacts Primary Sjögren's Syndrome.
CD166/ALCAM
CD5
CD6
SNP
Sjögren's syndrome
polymorphism
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
11
2021
accepted:
16
02
2022
entrez:
4
4
2022
pubmed:
5
4
2022
medline:
5
4
2022
Statut:
epublish
Résumé
Primary Sjögren's syndrome (pSS) is an autoimmune disease triggered by a combination of environmental and host genetic factors, which results in the focal lymphocytic infiltration of exocrine glands causing eye and mouth dryness. Glandular infiltrates include T and B cell subsets positive for CD5 and/or CD6, two surface scavenger receptors involved in the fine-tuning of intracellular signals mediated by the antigen-specific receptor complex of T (TCR) and B (BCR) cells. Moreover, the epithelial cells of inflamed glands overexpress CD166/ALCAM, a CD6 ligand involved in homo and heterotypic cell adhesion interactions. All this, together with the reported association of functionally relevant single nucleotide polymorphisms (SNPs) of
Identifiants
pubmed: 35372412
doi: 10.3389/fmed.2022.822290
pmc: PMC8971656
doi:
Types de publication
Journal Article
Langues
eng
Pagination
822290Informations de copyright
Copyright © 2022 Casadó-Llombart, Gheitasi, Ariño, Consuegra-Fernández, Armiger-Borràs, Kostov, Ramos-Casals, Brito-Zerón and Lozano.
Déclaration de conflit d'intérêts
FL is a founding partner at Sepsia Therapeutics SL. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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