Induction and Donor Specific Antibodies in Low Immunologic Risk Kidney Transplant Recipients.
antibodies
donor specific antibody
induction
kidney transplantation
tissue donors
transplantation
Journal
Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381
Informations de publication
Date de publication:
31 12 2020
31 12 2020
Historique:
received:
13
01
2020
accepted:
01
10
2020
entrez:
4
4
2022
pubmed:
1
10
2020
medline:
8
4
2022
Statut:
epublish
Résumé
Optimal induction for patients without pretransplant donor-specific antibodies (DSAs) is poorly defined. The goal of this study was to compare the incidence of A retrospective chart review was performed, identifying 782 patients with a negative VXM who underwent kidney transplantation at a single, high-volume institution between January 2013 and May 2017. Kaplan-Meier analysis was used to assess the incidence of dnDSA and allograft survival between induction therapies in this group. dnDSA is defined as the development of new post-transplant DSA, at any MFI level. Induction therapy included alemtuzumab ( In summary, alemtuzumab was associated with a higher rate of dnDSA development in patients with a negative VXM; however, this finding was not associated with rejection or graft failure.
Sections du résumé
Background
Optimal induction for patients without pretransplant donor-specific antibodies (DSAs) is poorly defined. The goal of this study was to compare the incidence of
Methods
A retrospective chart review was performed, identifying 782 patients with a negative VXM who underwent kidney transplantation at a single, high-volume institution between January 2013 and May 2017. Kaplan-Meier analysis was used to assess the incidence of dnDSA and allograft survival between induction therapies in this group. dnDSA is defined as the development of new post-transplant DSA, at any MFI level.
Results
Induction therapy included alemtuzumab (
Conclusions
In summary, alemtuzumab was associated with a higher rate of dnDSA development in patients with a negative VXM; however, this finding was not associated with rejection or graft failure.
Identifiants
pubmed: 35372884
doi: 10.34067/KID.0000122020
pii: K3602020000012
pmc: PMC8815535
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1407-1418Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
Déclaration de conflit d'intérêts
All authors have nothing to disclose.
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