APOL1
African Americans
CKD
FSGS
chronic kidney disease
genetics
kidney
metabolomics
mitochondria
Journal
Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381
Informations de publication
Date de publication:
31 12 2020
31 12 2020
Historique:
received:
02
06
2020
accepted:
29
09
2020
entrez:
4
4
2022
pubmed:
30
9
2020
medline:
8
4
2022
Statut:
epublish
Résumé
Kidney risk variants (KRVs) in the We performed a metabolomics analysis using HEK293 Tet-on cells conditionally expressing Alterations in the tricarboxylic acid cycle, increased fatty acid oxidation, and compromised redox homeostasis were the major pathways affected by overexpression of Impairment of mitochondrial membrane respiratory chain complex I appeared to account for critical metabolic consequences of
Sections du résumé
Background
Kidney risk variants (KRVs) in the
Methods
We performed a metabolomics analysis using HEK293 Tet-on cells conditionally expressing
Results
Alterations in the tricarboxylic acid cycle, increased fatty acid oxidation, and compromised redox homeostasis were the major pathways affected by overexpression of
Conclusions
Impairment of mitochondrial membrane respiratory chain complex I appeared to account for critical metabolic consequences of
Identifiants
pubmed: 35372896
doi: 10.34067/KID.0003592020
pii: K3602020000359
pmc: PMC8815529
doi:
Substances chimiques
APOL1 protein, human
0
Apolipoprotein L1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1353-1362Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL119962
Pays : United States
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
Déclaration de conflit d'intérêts
Wake Forest University Health Sciences and B. Freedman have rights to an issued US patent related to APOL1 genetic testing. B. Freedman is a consultant for AstraZeneca Pharmaceuticals and RenalytixAI. All remaining authors have nothing to disclose.
Références
Trends Endocrinol Metab. 2018 Jan;29(1):18-30
pubmed: 29221849
Sci Rep. 2016 Dec 08;6:38299
pubmed: 27929071
Annu Rev Biochem. 2006;75:69-92
pubmed: 16756485
Am J Transplant. 2012 Jul;12(7):1924-8
pubmed: 22487534
Amino Acids. 2012 Jun;42(6):2223-32
pubmed: 21691752
Biochim Biophys Acta. 2011 Nov;1807(11):1390-7
pubmed: 21749854
Int J Mol Sci. 2012;13(3):3145-75
pubmed: 22489146
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Int J Biochem. 1979;10(8):723-31
pubmed: 499640
Philos Trans R Soc Lond B Biol Sci. 2005 Dec 29;360(1464):2355-72
pubmed: 16321806
Biochim Biophys Acta. 2012 Jun;1817(6):851-62
pubmed: 21924235
Science. 2010 Aug 13;329(5993):841-5
pubmed: 20647424
Cell Metab. 2016 Apr 12;23(4):635-48
pubmed: 26924217
PLoS One. 2016 Apr 07;11(4):e0152775
pubmed: 27054572
J Am Soc Nephrol. 2017 Apr;28(4):1093-1105
pubmed: 27821631
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):780-785
pubmed: 29317536
J Am Soc Nephrol. 2017 Apr;28(4):1117-1130
pubmed: 27864431
JCI Insight. 2017 Jul 20;2(14):
pubmed: 28724794
J Am Soc Nephrol. 2015 Feb;26(2):339-48
pubmed: 25012173
J Am Soc Nephrol. 2017 Nov;28(11):3227-3238
pubmed: 28696248
J Lipid Res. 2015 Aug;56(8):1583-93
pubmed: 26089538
Elife. 2016 Jun 16;5:
pubmed: 27307216
Kidney Int Rep. 2020 Mar 30;5(6):891-904
pubmed: 32518871
Nat Protoc. 2009;4(11):1582-90
pubmed: 19816421
Nat Med. 2017 Apr;23(4):429-438
pubmed: 28218918
Cell Rep. 2020 Mar 17;30(11):3821-3836.e13
pubmed: 32187552
Sci Rep. 2017 Sep 5;7(1):10492
pubmed: 28874733
Diabetes. 2012 Aug;61(8):2074-83
pubmed: 22586586
Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):91-5
pubmed: 15987648
J Am Soc Nephrol. 2019 Dec;30(12):2355-2368
pubmed: 31558683
Am J Transplant. 2011 May;11(5):1025-30
pubmed: 21486385
Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6314-E6321
pubmed: 28716925